3MPR,3L1W,3G6S


Conserved Protein Domain Family
EEP-1

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cd09083: EEP-1 
Click on image for an interactive view with Cn3D
Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1
This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.
Statistics
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PSSM-Id: 197317
Aligned: 94 rows
Threshold Bit Score: 212.847
Created: 24-Aug-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative catalytic site [active site]
Evidence:
  • Comment:based on other EEP superfamily members with structure; highly conserved in the EEP superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1             #                                  #                                       
3MPR_A         8 TVASYNLR.[12].WGQRYPVIAQXVQY.[2].FDIFGTQECF.[1].HQLKDXKEAL.[ 2].YDYIGVGRD.[4].KG 81  Bacteroides thetaiot...
NP_194819      6 SVMSFNLH.[10].WLKRKDLCLTVITS.[2].PIVLCTQQGV.[1].SQLDYLQQGL.[ 2].YDQFGISRT.[5].ND 78  thale cress
ZP_07198427    2 RVMTFNLR.[10].WSCRRDLVVKLIER.[2].PDILGTQEGR.[1].SPLAYLDAHL.[ 2].YDIHMPSRV.[3].TC 72  delta proteobacteriu...
YP_001529660  12 SVMSLNVR.[10].WENRKPAFVELFKQ.[2].PDFIGMQEVN.[1].FQAAFFAGLL.[ 2].YHAIGKRTP.[3].GW 82  Desulfococcus oleovo...
ZP_05065846   32 RVATYNVH.[15].WERRKGALQAAFVS.[2].ADVVGFQEME.[1].FGRGQAPQNL.[11].YAAAAVGDP.[2].FP 115 Octadecabacter antar...
YP_002601873   8 SVMTFNLR.[10].WENRKKGYPLLFEH.[2].PDFVGFQEVN.[1].FQADFLCRLL.[ 2].YGFIGRRDT.[3].LW 78  Desulfobacterium aut...
YP_002432311   5 SAMTANLR.[10].WEFRKDAFMKLFRT.[2].PDILAVQEAN.[1].FQAEHLIQRM.[ 2].YDHAGFRKN.[3].FW 75  Desulfatibacillum al...
NP_641025     35 RVMSFNVR.[10].WQVRRAAMVALIKQ.[2].PDVFGTQELV.[1].EQAAFLAEQL.[ 2].YRWFGQGRR.[3].SD 105 Xanthomonas axonopod...
ZP_01619868    2 KIVTFNVR.[10].WVWRRQVMAQLMAE.[2].ADLVGTQEGK.[1].HQLLDLHRRL.[ 2].YQTVGVDRQ.[3].LS 72  Lyngbya sp. PCC 8106
CAO87155       4 TAMSFNIR.[10].WRVRREAVAALIAH.[2].PDIIGTQEAR.[1].NQLLDLHRLL.[ 2].YQSLGSDRR.[3].LD 74  Microcystis aerugino...

Feature 1                                                                                #    
3MPR_A        82 EHSAIFY.[2].DKFDIVEKGDFWLSETP.[2].PSKGWD     AVLPRICSWGHFKCK.[4].EFLFFNLHXDHI 146 Bacteroides thetaiotaom...
NP_194819     79 EHCTIFF.[2].EKVELLEGGTFWLSESP.[3].GSTAWG     SAVPCIATWATFQLK.[7].SFQIVNTNLDEI 147 thale cress
ZP_07198427   73 QYPTLFF.[2].DRFRILEGKEFWLSKTP.[3].RSKDWD     SAFPRMVSTATLELR.[4].IFSVAVTHLDHM 138 delta proteobacterium N...
YP_001529660  83 QDVLIFY.[1].KNWECRDCDRFFLSDTP.[2].PSRMPD     SRWPRQCVMGTFEKE.[2].RMVCVNTHFDFD 144 Desulfococcus oleovoran...
ZP_05065846  116 STQPIFY.[2].DRLTLRDQGWFFFSDTP.[3].YSRTFN     GSWPAFTSWAEFEDR.[3].IFRVYNLHTEYR 180 Octadecabacter antarcti...
YP_002601873  79 QNNLIFY.[1].KQWTCKAANHLFLSRTP.[2].ESRLDG     SRWPRQCTLGQFEQG.[2].AVVMANTHFDFA 140 Desulfobacterium autotr...
YP_002432311  76 QSNILFF.[1].KPWSLKKHRHIFYSDTP.[1].EESKWK.[1].SKWPRQGTLVQLEKG.[2].TLACVDTHYDFK 137 Desulfatibacillum alken...
NP_641025    106 EHMGVFY.[2].RVLEVVESGDFWLSDTP.[3].GSITWG     NVLPRMATWALFERR.[4].RFYLFNTHFPYR 171 Xanthomonas axonopodis ...
ZP_01619868   73 EYCAIFY.[2].QRWRCLKTGDFWLSKTP.[3].GSVTAE.[2].NPVPRMVSWGVFEGV.[4].PIIIFNTHFDYH 140 Lyngbya sp. PCC 8106
CAO87155      75 EHCAILY.[2].SRLKCLEIYEFWLSETP.[5].ITEAWG     NPYPRMVTGAKFRTL.[3].TLQFYNTHLDYY 141 Microcystis aeruginosa ...

Feature 1                                        # #                                           
3MPR_A       147 .[1].KKARVESAFLVQEKX.[ 9].PAILTGDFN.[5].QSYDAF.[ 4].VLCDSYE.[2].DYR.[4].GTFNNF 217 Bacteroides thetaiotao...
NP_194819    148 .[1].PRARRRSALLTWQHI.[ 7].PVVYCGGFN.[5].TTGRFL.[11].DMRDAWP.[1].ARV.[7].RTYHDF 225 thale cress
ZP_07198427  139 .[1].QTARLKQAEIISRWV.[ 5].PVILMGDFN.[5].DAHAVL.[ 5].GLSDVWQ.[2].GHA.[5].FTHHGF 207 delta proteobacterium ...
YP_001529660 145      EPVQVKSAAILLARL.[ 8].PVLITGDFN.[5].DCHRAF.[ 5].LTRPFFD.[1].FDG.[3].GTFHKF 212 Desulfococcus oleovora...
ZP_05065846  181 .[1].MSNKQLSVALVAARI.[ 7].PVFVIGDFN.[1].IRGSTT.[ 2].VLEDANV.[1].FWP.[3].STFHFN 241 Octadecabacter antarct...
YP_002601873 141      ETVQALSAGLVVDFL.[11].PTVITGDFN.[5].AAHRVF.[ 3].GFEDAFE.[1].AHA     YTFHGF 206 Desulfobacterium autot...
YP_002432311 138      PEVQARSARLLLNIL.[ 7].PTLVMGDFN.[5].SCRKEF.[ 3].GFKDPFD.[1].RFG     GTHHGF 199 Desulfatibacillum alke...
NP_641025    172 .[3].EPARERSARLILSRI.[ 7].PVVLTGDFN.[5].ITYPTL.[ 2].VLRDARA.[2].SKR.[4].NTFQDF 240 Xanthomonas axonopodis...
ZP_01619868  141 .[1].QRARELSAQLISDRL.[ 8].LFIVTGDFN.[5].FTRKTL.[ 8].VLCDTLA.[1].IDL.[3].MTYHEF 212 Lyngbya sp. PCC 8106
CAO87155     142 .[1].DKAKDLGAKCIQERF.[ 8].YLFLTGDFN.[5].LPRQIL.[ 8].KLKDALA.[2].ELA.[2].MSFNNY 213 Microcystis aeruginosa...

Feature 1                  #                           ##       
3MPR_A       218 .[ 6].ESRIDHIFV.[3].FHVKRYGVLTD.[31].SDHFPVKVEL 287 Bacteroides thetaiotaomicron
NP_194819    226 .[27].DLHTDWILY.[4].IVPVMCEIVND.[ 7].SSHYPVFAEF 293 thale cress
ZP_07198427  208 .[ 5].KSRIDWILS.[3].PYAVDARLLHD.[ 7].SDHFPYYVDF 252 delta proteobacterium NaphS2
YP_001529660 213 .[ 5].SDRIDWILC.[3].GGPREKRIITD.[ 7].SDHFPVYAEF 257 Desulfococcus oleovorans Hxd3
ZP_05065846  242 .[ 5].FPAIDHIGG.[5].PVGKTFSVRGR.[ 6].TDHYPVVGDF 287 Octadecabacter antarcticus 238
YP_002601873 207 .[ 5].GGHIDWILY.[3].ITPLNQKIVRE.[ 7].SDHFPVLVEF 251 Desulfobacterium autotrophicum HRM2
YP_002432311 200 .[ 5].GRRIDWILY.[5].PVKASRKIIRG.[ 7].SDHFQVYCEF 246 Desulfatibacillum alkenivorans AK-01
NP_641025    241 .[ 4].TRRIDWILY.[2].LRPSRFATLDD.[ 7].SDHYPVMAEF 283 Xanthomonas axonopodis pv. citri str. 306
ZP_01619868  213 .[ 4].FAAVDTIYY.[3].LNLHQVSVDRT.[ 7].SDHFPVIAQF 256 Lyngbya sp. PCC 8106
CAO87155     214 .[ 4].YLAIDTIYY.[3].LQLDWVKVDPS.[ 7].SDHYPVIAAF 257 Microcystis aeruginosa PCC 7806

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