Conserved Protein Domain Family
CRD_FZ6

?
cd07450: CRD_FZ6 
Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor.
The cysteine-rich domain (CRD) is an essential extracellular portion of the frizzled 6 (Fz6) receptor, and is required for binding Wnt proteins, which play fundamental roles in many aspects of early development, such as cell and tissue polarity, neural synapse formation, and the regulation of proliferation. Fz proteins serve as Wnt receptors for multiple signal transduction pathways, including both beta-catenin dependent and -independent cellular signaling, as well as the planar cell polarity pathway and Ca(2+) modulating signaling pathway. CRD containing Fzs have been found in diverse species from amoebas to mammals. 10 different frizzled proteins are found in vertebrata. Frizzled 6 (Fz6) is expressed in the skin and hair follicles and controls hair patterning in mammals using a Fz-dependent tissue polarity system, which is similar to the one that patterns the Drosophila cuticle.
Statistics
?
PSSM-Id: 143559
Aligned: 7 rows
Threshold Bit Score: 231.193
Created: 23-Jan-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative Wnt
Feature 1:putative Wnt binding site [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:

Feature 1                # ### ###                                                            
Q5RCN4     21 SLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFL.[2].ANLECSPNIETFLCKAFVPTCTEQIHV.[1]. 93  Sumatran orangutan
O60353     20 SLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFL.[2].ANLECSPNIETFLCKAFVPTCIEQIHV.[1]. 92  human
Q61089     20 SLFTCEPITVPRCMKMTYNMTFFPNLMGHYDQGIAAVEMGHFL.[2].ANLECSPNIEMFLCQAFIPTCTEQIHV.[1]. 92  house mouse
AAH84094   23 SLFTCEPITVPRCTGMNYNMTFFPNLMEHYDQDIAALRMEPFL.[2].LNLHCSPEVHMFLCRAFVPECTEPKHI.[1]. 95  African clawed frog
XP_418372  21 SLFTCEPITISRCSRMPYNMTFFPNIMGHYDQDTAALQMEPFL.[2].MNLHCSPDVHTFLCKAFVPACLEQVHV.[1]. 93  chicken
CAF98078   23 SLFTCEPIKVHWCLGMPYNMTYFPNMMDHFDQDIAATNMKPFM.[2].IKLRCSPGVHHFLCQAFFPACFENVGS      94  spotted green pufferfish
NP_956855  20 TLFTCEPVQVQWCLDMPYNTTFFPNMLEHYDQDIAAVRMKEFM.[2].VSVRCSPDAHLFLCQAFVPECRTHSHS.[7]. 98  zebrafish

Feature 1                                                               
Q5RCN4     94 PPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVP.[1].TFDPHTEFLGP 147 Sumatran orangutan
O60353     93 PPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVP.[1].TFDPHTEFLGP 146 human
Q61089     93 LPCRKLCEKIVSDCKKLMDTFGIRWPEELECNRLPHCDDTVP.[1].TSHPHTELSGP 146 house mouse
AAH84094   96 MPCRSLCERVHSDCKNLIETFGITWPAELECDRMRDCNYSQS.[9].DARQHPEKVSK 157 African clawed frog
XP_418372  94 HPCRNLCEKVYSDCKQLIDTFGITWPEELECSRLVNCDETAP.[5].TTNAHGTQKTP 151 chicken
CAF98078   95 RPCREECKTVLSDCKDNIQVFGISWPPELQCDKLDPCFLTRD.[1].TTPETPPATSP 148 spotted green pufferfish
NP_956855  99 RPCRERCERVRSDCRAVMHTFDISWPSELQCERLESCGGSAV.[3].TAGRSGAGSSP 154 zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap