1ZXC,2A8H


Conserved Protein Domain Family
ZnMc_TACE_like

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cd04270: ZnMc_TACE_like 
Click on image for an interactive view with Cn3D
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
Statistics
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PSSM-Id: 239798
Aligned: 15 rows
Threshold Bit Score: 332.801
Created: 23-May-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
  • Structure:1ZXC: Human TACE coordinates Zinc
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                                                                      
1ZXC_B       9 NTCKLLVVADHRFYRYMG.[ 5].TTTNYLIELIDRVDDIYRNTA.[ 8].YGIQIEQIRILKSPQEVKPGE.[ 9].PN 92   human
O14672     220 NTCQLYIQTDHLFFKYYG.[ 3].AVIAQISSHVKAIDTIYQTTD.[ 6].ISFMVKRIRINTTADEKDPTN.[ 4].PN 294  human
Q9VAC5     223 TRCPLLLVADYRFFQEMG.[ 5].TTINYLISLIDRVHKIYNDTV.[12].MGFVIKKIVVHSEPTRLRGGE.[ 2].YN 303  fruit fly
Q8JIY1     220 NTCQLFIQTDHLFYKRYG.[ 4].AVIAQISSHVKAIDTIYQSTD.[ 6].ISFMVKRIRINVTSDEKDPTN.[ 4].PN 295  African clawed frog
CAH65250   221 NTCQLYIQTDHLFYKHYG.[ 3].AVIAQISSHVKAIDTIYRSTD.[ 6].ISFMVKRIRINTTVDEKDPSN.[ 4].PN 295  chicken
AAH54638   225 NTCQLFIQTDHLFYKYYK.[ 3].AVIAQISSHVKAIDAIYQGTD.[ 6].ISFMVKRIRINTTSDERDRSN.[ 4].AN 299  zebrafish
XP_790625  100 HVCPMLLTADYRFYQSMG.[ 5].ISMNYLVSLVDRVDVIYKTTE.[ 7].FQFQIKKIVIHQNPSPTSADN.[ 7].KP 180  purple urchin
AAB09097   187 NRCTLKLVADYSFYSIFG.[ 5].IVTKFLVNMIARVNEIYTPIN.[17].MGFSIKEIKVLDRPNASDSHY.[ 4].RI 274  nematode
CAB09416   242 RTCSLYMQADHKLYEHIR.[13].EIVSLFYNHIKAVNEIYEGTN.[ 6].LHFVIQRTSIYTPDSCDRGRA.[10].EN 332  nematode
NP_651716  479 TTCMLYLQADHTFFQKMG.[ 3].ASIEAITRHVQRANTIYRNTD.[ 9].ITFMIKRIKVHNMNAMKDPSY.[ 3].GN 555  fruit fly

Feature 1                                                                                    
1ZXC_B      93 EEKDAWD.[1].KMLLEQFSF.[9].CLAHLFTYQDFD.[3].LGLAYVGS.[4].SHGGVCP.[12].YLNSGLTST 173  human
O14672     295 IGVEKFL     ELNSEQNHD.[2].CLAYVFTDRDFD.[3].LGLAWVGA.[3].SSGGICE.[11].SLNTGIITV 365  human
Q9VAC5     304 MIREKWD.[1].RNLLEVFSR.[7].CLAHLFTDLKFE.[3].LGLAYVGS.[4].SVGGICT.[10].YLNSGLSSS 380  fruit fly
Q8JIY1     296 IGVEKFL     ELNSEQNHD.[2].CLAYVFTDRDFD.[3].LGLAWVGA.[3].SSGGICE.[11].SLNTGIITV 366  African clawed frog
CAH65250   296 IGVEKFL     ELNSEQNHD.[2].CLAYVFTDRDFD.[3].LGLAWVGA.[3].SSGGICE.[11].SLNTGIITV 366  chicken
AAH54638   300 IGVEKFL     ELNSEQNHD.[2].CLAYVFTDRDFD.[3].LGLAWVGA.[3].SSGGICE.[11].SLNTGIITV 370  zebrafish
XP_790625  181 WGVQELL.[1].VYSKEDHSA.[1].CLAHLFTYQDFS.[3].LGLAYIGT.[4].AVGGICT.[11].YLNTGLTTT 252  purple urchin
AAB09097   275 WEVERLL.[2].FAFAEGSKD.[1].CLVHLVTARTFR.[4].LGLAYVSY.[5].TAGGICS.[10].YINVLLSTS 348  nematode
CAB09416   333 VDVSNFL.[1].LNSQRNHSA.[1].CLAYALTFRDFV.[3].LGLAWVAS.[4].TAGGICQ.[15].SLNTGIVTL 408  nematode
NP_651716  556 YGVEKFL.[1].LFSEEDYDA.[1].CLAYMFTYRDFE.[3].LGLAWTGD.[2].NAGGVCE.[10].SLNTGIVTL 624  fruit fly

Feature 1                    ##  #     #                                                      
1ZXC_B     174 .[ 9].KEADLVTTHELGHNFGAEHDP.[ 4].ECAPN.[ 4].GKYVMYPIAV.[5].NNKMFSQCSKQSIYKTIESK 251  human
O14672     366 .[ 9].KVSHITFAHEVGHNFGSPHDS.[ 2].ECTPG.[10].GNYIMYARAT.[5].NNNKFSLCSIRNISQVLEKK 447  human
Q9VAC5     381 .[10].READLVTAHEFGHNWGSEHDP.[ 3].ECSPS.[ 4].GSFLMYTYSV.[5].NNKKFSPCSLRSIRKVLQAK 458  fruit fly
Q8JIY1     367 .[ 9].KVSHITFAHEVGHNFGSPHDS.[ 2].ECTPG.[10].GNFIMYARTT.[5].NNNKFSICSVRNISQVLDKK 448  African clawed frog
CAH65250   367 .[ 9].KVSHITFAHEVGHNFGSPHDS.[ 2].ECTPG.[10].GNYIMYARAT.[5].NNNKFSLCSIRNISQVLEKK 448  chicken
AAH54638   371 .[ 9].KVSHITFAHEVGHNFGSPHDS.[ 2].ECTPG.[10].GNYIMYARAT.[5].NNNKFSVCSIKNISQVLEKK 452  zebrafish
XP_790625  253 .[ 9].EEADLVTAHELGHNFGSEHDP.[ 5].ECAPG.[ 4].GNFLMYPASV.[5].NNRKFSICSKRLISPVLREK 331  purple urchin
AAB09097   349 .[13].KEIDIVVSHEYGHAWGATHDP.[10].ECSPN.[ 4].GKYLMSQYAQ.[5].NNVLFSPCSRKLIRDVLIGK 436  nematode
CAB09416   409 .[ 9].RVSQLTLAHEIGHNFGSPHDF.[ 2].ECQPG.[ 3].GNFIMFASAT.[5].NNGKFSPCSVKNISAVLAVV 483  nematode
NP_651716  625 .[ 9].AVSHVTLAHEIGHNFGSPHDP.[ 1].QCTPG.[ 3].GNFIMFARAT.[5].NNNKFSTCSLKSIEPVLNAK 698  fruit fly

Feature 1                        
1ZXC_B     252       AQECFQERSNKV 263  human
O14672     448       RNNCFVESGQPI 459  human
Q9VAC5     459       SGRCFSEPEESF 470  fruit fly
Q8JIY1     449       ENSCFVESGQPI 460  African clawed frog
CAH65250   449       RNNCFVESGQPI 460  chicken
AAH54638   453       RGSCFVESGQPI 464  zebrafish
XP_790625  332       SARCFVEPSQTS 343  purple urchin
AAB09097   437       WESCFQEEMTSF 448  nematode
CAB09416   484 .[18].KRNCFQERTSAF 513  nematode
NP_651716  699 .[ 3].MKGCFTEPQSSI 713  fruit fly

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