2J5W,1KCW,1KCW,2R7E,2R7E,3CDZ,1SDD,1SDD


Conserved Protein Domain Family
CuRO_1_ceruloplasmin_like

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cd04199: CuRO_1_ceruloplasmin_like 
Click on image for an interactive view with Cn3D
Cupredoxin domains 1, 3, and 5 of ceruloplasmin and similar proteins
This family includes the first, third, and fifth cupredoxin domains of ceruloplasmin and similar proteins including the first, third and fifth cupredoxin domains of unprocessed coagulation factors V and VIII. Ceruloplasmin (ferroxidase) is a multicopper oxidase essential for normal iron homeostasis. It functions in copper transport, amine oxidation and as an antioxidant preventing free radicals in serum. The protein has 6 cupredoxin domains and exhibits internal sequence homology that appears to have evolved from the triplication of a sequence unit composed of two tandem cupredoxin domains. Human Factor VIII facilitates blood clotting by acting as a cofactor for factor IXa. Factor VIII and IXa forms a complex in the presence of Ca+2 and phospholipids that converts factor X to the activated form Xa.
Statistics
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PSSM-Id: 259862
Aligned: 10 rows
Threshold Bit Score: 259.26
Created: 13-Dec-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
trinuclear Cu
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: trinuclear Cu binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H H H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the trinuclear copper binding site of other multicopper oxidases with structure of bound coppers
  • Comment:Trinuclear copper site ligands are typically one or two HxH motifs that can be in the same domain/subunit or in different domains/subunits.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                                                              # #   
2J5W_A     372 RHYYIAAEEIIWNY.[33].SYKKLVYREYTD.[15].LGILGPVIWAEVGDTIRVTFHNKG.[1].YPLSIEPIGVR 481  human
1KCW_A     713 RTYYIAAVEVEWDY.[32].KYKKVVYRQYTD.[15].LGILGPQLHADVGDKVKIIFKNMA.[1].RPYSIHAHGVQ 821  human
1KCW_A       3 KHYYIGIIETTWDY.[30].LYKKALYLQYTD.[12].LGFLGPIIKAETGDKVYVHLKNLA.[1].RPYTFHSHGIT 106  human
2R7E_A     383 WVHYIAAEEEDWDY.[26].KYKKVRFMAYTD.[12].SGILGPLLYGEVGDTLLIIFKNQA.[1].RPYNIYPHGIT 482  human
2R7E_A       4 RRYYLGAVELSWDY.[28].VYKKTLFVEFTD.[12].MGLLGPTIQAEVYDTVVITLKNMA.[1].HPVSLHAVGVS 105  human
3CDZ_B      48 RHYFIAAVERLWDY.[19].QFKKVVFQEFTD.[15].LGLLGPYIRAEVEDNIMVTFRNQA.[1].RPYSFYSSLIS 143  human
1SDD_A       4 RQFYVAAQSIRWNY.[14].SFKKIVYREYEA.[11].SGLLGPTLYAEVGDIMKVHFKNKA.[1].KPLSIHAQGIK 90   cow
NP_841583   36 REYWIAAEKTDWNY.[21].TYTKYRYIGYTD.[12].MGILGPTIRAAVGDTIKIHFLNKT.[1].MPLSMHPHGVM 130  Nitrosomonas europaea A...
1SDD_B       7 KYYYIAAEEISWDY.[16].VYKKVVFRKYLD.[15].LGILGPVIRAEVDDVIQVRFKNLA.[1].RPYSLHAHGLS 99   cow
P12259     350 WEYFIAAEEVIWDY.[26].HYKKVMYTQYED.[14].DGILGPIIRAQVRDTLKIVFKNMA.[1].RPYSIYPHGVT 451  human

Feature 1                                         # #                       
2J5W_A     482 .[27].VAPTETFTYEWTVPKE.[7].PVCLAKMYYSAVD.[2].KDIFTGLIGPMKICKK 562  human
1KCW_A     822 .[ 8].TLPGETLTYVWKIPER.[7].SACIPWAYYSTVD.[2].KDLYSGLIGPLIVCRR 883  human
1KCW_A     107 .[23].VYPGEQYTYMLLATEE.[7].GNCVTRIYHSHID.[2].KDIASGLIGPLIICKK 183  human
2R7E_A     483 .[21].ILPGEIFKYKWTVTVE.[7].PRCLTRYYSSFVN.[2].RDLASGLIGPLLICYK 557  human
2R7E_A     106 .[23].VFPGGSHTYVWQVLKE.[7].PLCLTYSYLSHVD.[2].KDLNSGLIGALLVCRE 182  human
3CDZ_B     144 .[15].VKPNETKTYFWKVQHH.[7].FDCKAWAYFSDVD.[2].KDVHSGLIGPLLVCHT 212  human
1SDD_A      91 .[23].VAPGQEYTYEWIISEH.[7].PPCLTHIYYSYVN.[2].EDFNSGLIGPLLICKK 167  cow
NP_841583  131 .[15].IPPGERYTYTWIVDQD.[7].PSSIVWLYHSHVM.[2].EEVNLGLIGTLIITAA 199  Nitrosomonas europaea ATCC 19718
1SDD_B     100 .[23].IQPNKTYTYVWHATTR.[7].SACRAWAYYSAVN.[2].KDIHSGLIGPLLICRK 176  cow
P12259     452 .[23].VQPGETYTYKWNILEF.[7].AQCLTRPYYSDVD.[2].RDIASGLIGLLLICKS 528  human

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