Conserved Protein Domain Family
GTPBP_II
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cd03694: GTPBP_II 
Domain II of the GTPBP family of GTP binding proteins
This group includes proteins similar to GTPBP1 and GTPBP2. GTPBP1 is structurally related to elongation factor 1 alpha, a key component of the protein biosynthesis machinery. Immunohistochemical analyses on mouse tissues revealed that GTPBP1 is expressed in some neurons and smooth muscle cells of various organs as well as macrophages. Immunofluorescence analyses revealed that GTPBP1 is localized exclusively in cytoplasm and shows a diffuse granular network forming a gradient from the nucleus to the periphery of the cells in smooth muscle cell lines and macrophages. No significant difference was observed in the immune response to protein antigen between mutant mice and wild-type mice, suggesting normal function of antigen-presenting cells of the mutant mice. The absence of an eminent phenotype in GTPBP1-deficient mice may be due to functional compensation by GTPBP2, which is similar to GTPBP1 in structure and tissue distribution.
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Statistics
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PSSM-Id: 293895
Aligned: 22 rows
Threshold Bit Score: 93.0533
Created: 23-Aug-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

AAB90495  388 FLMYIDKIYSV.[1].GVGTVVSGSVKSGELAEGDEVYIGP.[3].GSFRRVRIQSIEMH.[1].YRIDRAKAGDIIGAA 457 Archaeoglobus fulgidus ...
AAG19926  361 FRMYVDRTYSV.[1].GVGAVASGTVKSGTVEDGETLLLGP.[3].GSFRTVEVRSIEMH.[1].HRVDSAQAGRIVGIA 430 Halobacterium sp. NRC-1
AAL63708  339 FLMYISDIYLV.[1].GVGVVIGGLVEKGILHVGDRVWLGP.[3].GKWMQTVVKSIHFN.[1].TPVESAKAGSFITVA 408 Pyrobaculum aerophilum ...
NP_506069 403 AFFTIEELYNV.[1].HVGQVVGGMLSEGQLHEGADVLVGP.[3].GTFEKITVGSIRRS.[1].QAVGCVNPGEAASIS 472 nematode
XP_419499 405 TEFQVDEIYTV.[1].EVGTVVGGTLSSGICREGEHLVVGP.[3].GKFLRLKVCSIQRN.[1].SACRVLRAGQAATLA 474 chicken
AAK93508  450 CEFQVDEIFRV.[1].DVGPVVGGLLVQGVLTENMAMKIGP.[3].GSFHPVTVNTIHRN.[1].APCRVVRAGQSASLS 519 fruit fly
AAK42573  345 PLVYIDEIYNV.[1].GVGTVVLGSVVRGKLNNNESVLIGP.[3].GEFKEVKIKSIQVN.[1].VFVDSVLAGNIATFA 414 Sulfolobus solfataricus P2
XP_972902 376 PEFQIDENFKA.[1].DVGQIIGGLLTKGVITEGMQMQIGP.[3].GSFLNVVIKSIHRN.[1].VPCRMVRAGQSAALC 445 red flour beetle
AAF78884  369 TEFQVDEIYTV.[1].EVGTVVGGTLSSGICREGDQLVVGP.[3].GCFLELRVCSIQRN.[1].SACRVLRAGQAATLA 438 human
AAX79037  409 FEVLLDGCFLV.[1].GVGPVVKGHVSKGSVELGCRCNIGP.[3].GKFHAVTVRGIHVD.[1].SHVTRAQQSDEGTFA 478 Trypanosoma brucei


AAB90495  458 VK.[6].LRRGMVISR 474 Archaeoglobus fulgidus DSM 4304
AAG19926  431 LK.[6].IERGMVLLP 447 Halobacterium sp. NRC-1
AAL63708  409 LD.[4].VEKGMVLSA 423 Pyrobaculum aerophilum str. IM2
NP_506069 473 LN.[6].LRRGMVLAE 489 nematode
XP_419499 475 LG.[6].LRKGMVMVS 491 chicken
AAK93508  520 FS.[7].LRSGMVLLG 537 fruit fly
AAK42573  415 IQ.[6].LRKGMVMVK 431 Sulfolobus solfataricus P2
XP_972902 446 LS.[5].LRNGLVLLR 461 red flour beetle
AAF78884  439 LG.[6].LRKGMVMVS 455 human
AAX79037  479 LS.[8].SQKGKMLIP 497 Trypanosoma brucei
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