Conserved Protein Domain Family
Peptidase_C19I
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cd02665: Peptidase_C19I 
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
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Statistics
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PSSM-Id: 239130
Aligned: 7 rows
Threshold Bit Score: 201.633
Created: 22-Apr-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Active Site
Feature 1:Active Site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1            #    #                                                                       
XP_425805     133 GMKNIGNTCWFSAVIQSLFQ.[69].QQQDVSEFTHKLLDWLE.[ 17].NPMVQLFYGTFLTEGVHEG.[ 5].IETFG 284  chicken
Q09931        200 GLYNSGNTCWLNCLSQVLYS.[76].TQQDATEMLTLIFDWLQ.[ 64].NPMYVNEKEPSSTPTSLFG.[80].CPQFF 480  nematode
AAH77389      169 GLKNVGNTCWFSAVIQSLFN.[69].QQQDVSEFTHKLLDWLE.[ 17].NPMVELFYGRFLAVGVHEG.[ 5].TEMFG 320  African clawed frog
NP_001001886  169 GLKNVGNTCWFSAVIQSLFN.[69].QQQDVSEFTHKLLDWLE.[ 17].NPMVELFYGRFLAVGVLEG.[ 5].TEMFG 320  zebrafish
CAE57727      144 GLFNQGNTCWFNSLTQMLFS.[76].SQQDASEMLTLIMQWLG.[146].HDYAQIFQATSHMEKFSDS.[12].CPVCF 438  Caenorhabditis bri...
Q96RU2        163 GLKNVGNTCWFSAVIQSLFQ.[69].QQQDVSEFTHKLLDWLE.[ 17].NPMVQLFYGTFLTEGVREG.[ 5].NETFG 314  human
XP_522187     247 GLKNVGNTCWFSAVIQQDVS.[13].FQLAVNVNTYLNPNNPE.[ 15].NPMVQLFYGTFLTEGVREG.[ 5].NETFG 340  chimpanzee


Feature 1                                                                                         
XP_425805     285 QYPLQ.[5].NLNECLEGAMVEGE.[ 16].WFTKLP.[2].LTFELSRF.[10].KIHTKLEFPQTI.[194].QQVPY 561  chicken
Q09931        481 QLQVT.[2].NLHDALEAATFDHG.[ 10].LYDPLP.[2].IFFGLSRF.[ 8].KLHDKFTFPKII.[170].QQHKY 722  nematode
AAH77389      321 QYPLQ.[5].DLHECLEAAMIEGE.[ 16].WFTELP.[2].LTFELSRF.[10].KIHNKLEFPPCL.[180].NQVPY 583  African clawed frog
NP_001001886  321 QYPLQ.[5].DLHECLEAAMIEGE.[ 17].WFTELP.[2].LTFELSRF.[10].KIHNKLEFPSML.[189].MQVPY 593  zebrafish
CAE57727      439 NLPVS.[2].NLHDALEASTFEVR.[ 11].MYEALP.[2].FFVSLNRF.[ 7].KLHDKFTFPREI.[146].KKENY 656  Caenorhabditis bri...
Q96RU2        315 QYPLQ.[5].NLDECLEGAMVEGD.[ 16].WFTKLP.[2].LTFELSRF.[10].KIHNKLEFPQII.[187].RQVPY 584  human
XP_522187     341 QYPLQ.[5].NLDECLEGAMVEGD.[207].SSMEMP.[7].VTDEEINF.[ 4].LQRWRSEIEQDI.[ 23].RQVPY 636  chimpanzee


Feature 1                           #                #                               
XP_425805     562 HLHAVLVHEGQ.[2].AGHYWAFIY.[6].WLKYNDISVTESSWEELERDSFGG.[4].SAYCLMYI 625  chicken
Q09931        723 ELHAIIVHSGE.[2].RGHYWTYKL.[9].WEKLNDQNADRVDWPKVESDSFGT.[6].SAYMLMYV 791  nematode
AAH77389      584 KLHAVLVHEGQ.[2].AGHYWAYIF.[6].WMKYNDISVTKSSWEELERDSFGG.[4].SAYCLMYI 647  African clawed frog
NP_001001886  594 RLHAVLVHEGQ.[2].AGHYWAYIY.[6].WMKYNDIAVTKSSWEELVRDSFGG.[4].SAYCLMYI 657  zebrafish
CAE57727      657 ELKAMILHVGE.[2].RGHYWMYKL.[9].WEKLNDQSATPVDYSQIEKEAFGT.[6].SAYLLLYV 725  Caenorhabditis briggsae
Q96RU2        585 RLHAVLVHEGQ.[2].AGHYWAYIY.[6].WLKYNDISVTESSWEEVERDSYGG.[4].SAYCLMYI 648  human
XP_522187     637 RLHAVLVHEGQ.[2].AGHYWAYIY.[6].WLKYNDISVTESSWEEVERDSYGG.[4].SAYCLMYI 700  chimpanzee

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