1W25,3BRE,3EZU,2V0N


Conserved Protein Domain Family
GGDEF

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cd01949: GGDEF 
Click on image for an interactive view with Cn3D
Diguanylate-cyclase (DGC) or GGDEF domain
Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.
Statistics
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PSSM-Id: 143635
Aligned: 825 rows
Threshold Bit Score: 80.2932
Created: 13-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:the active site is formed at the diguanylate cyclase dimerization interface
  • Structure:1W25: Response regulator PleD in complex with Cyclic Di-GMP
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                            #  ##        #   #                       #
1W25_A     289 VTDQLTGLHNRRYMTGQLDS.[10].PVSALLIDIDFFKKINDTF     GHDIGDEVLREFALRLASNV.[3].DLPCR 365  Caulobacter vibrioides
NP_970745  361 AKSNLQGEANFTLNSTTLTQ.[13].EVYLLYLDIDKFKTINQLW     GYYAGNALIQHIYSMILAHI.[7].DSFMH 444  Treponema denticola A...
NP_213995  641 THNVETGLLNKVGFQKVLSP.[ 7].TGALIALDMVGFSRLIKEF     GEEAIKKLLKEIAVRLEKTF.[3].DIIAK 714  Aquifex aeolicus VF5
EDZ63478   236 YIDKATKLRNRKYLIDKLPE.[ 9].GGINMMIALSGIIEANEKI     GHQQVDKFFLAIANIFDAHA.[5].SIVAR 313  Campylobacterales bac...
EDZ62830   185 IFDNKFGVYNKRYLMTKIEQ.[ 8].KHKSSLIMIELSRELKDSV.[1].NEKAITLMTRTIARLLLKTS.[3].DTVAH 260  Campylobacterales bac...
CAJ74182   944 LIDELTMIFNHRYFQIRLVQ.[10].PLALILFDIDHFDNYVARK     GEYYGNLVIKKTSGLVKKNT.[3].DIFIR 1020 Candidatus Kuenenia s...
EDZ62594   154 SVDALTKASNKMHMTSIIKT.[11].SFSLMYIDVDDFNAFIRAN     GINATDATIKKIAMIIKRSI.[3].DILAH 231  Campylobacterales bac...
CAJ74890   587 VMDEFQGIYNKRYFTELLTK.[10].NLSLLILGPDNHKATTETY.[1].SNNAGNLLLQQIAGVLSDSV.[3].DIIAR 664  Candidatus Kuenenia s...
NP_952722  154 RIDTLTGVYNRRYLDERLSP.[10].ALSLILVGINDFSGITSAH     GHYAGELALKGCADVLAESI.[4].DWLAR 231  Geobacter sulfurreduc...
EDX90084    95 REDHLTGLFNRPHLLGMLER.[10].TVSILLIEIEDFTQLLDSY     GRHTGEKALRLFADCIREKI.[3].DLFGR 171  Alcanivorax sp. DG881

Feature 1       ####                                                                           
1W25_A     366 YGGEEFVVIMP.[2].ALADALRIAERIRMHVS.[14].VTISIGVSAT.[ 6].PEALLKRADEGVYQAK.[4].NAVV 449  Caulobacter vibrioides
NP_970745  445 VIGDEFSIFYF.[1].NEEEVCRFTQTLIDKIN.[12].ISISVGIVNI.[ 6].SQEIISNAYDACSIAF.[4].GCYE 525  Treponema denticola A...
NP_213995  715 GDGDEFLIFAY.[3].KKDDVLSLIEKIRQKFS.[11].LSFYIGVVTY.[ 6].FSELYYRAITAVKEAK.[4].GEVV 796  Aquifex aeolicus VF5
EDZ63478   314 MNGTEFSILLP.[2].SDKEGINLAKGIYSSCK.[12].TFISLGLYSY.[ 5].IGQLLSHSDNALAQAK.[4].NIYL 394  Campylobacterales bac...
EDZ62830   261 YGNGVFAMLLK.[2].DIPSALKASERLCELVS.[12].LKISIGITDI.[ 5].VEEIVVSAMDGIEKAY.[4].IDFA 341  Campylobacterales bac...
CAJ74182  1021 YGNSTFALLLT.[2].IMSSATNLAKRFVSTIH.[14].ITISLGLVEF.[ 4].PEEFVYAAEFSLSAAA.[4].NRVE 1102 Candidatus Kuenenia s...
EDZ62594   232 WHGDKFMISFA.[2].SKDELDDTAKAIRDKIS.[ 9].LTCSISIVEI.[ 5].INTIIDKLQNSIKLSK.[4].GSIV 309  Campylobacterales bac...
CAJ74890   665 YDKAEFAIIMP.[2].FATRALVKADGIRQRVE.[14].ITISIGISSF.[ 6].VEPLVTLANKAFYKAK.[4].NRVE 748  Candidatus Kuenenia s...
NP_952722  232 YDDDRFVVVLP.[2].DASGAMILAKRLRIRIA.[12].VNAAFGVAGF.[10].PHILLDKADRSLREAL.[4].EMIK 317  Geobacter sulfurreduc...
EDX90084   172 FDGAQFLLVLP.[2].NFDDAARMGEGLKALAG.[18].VCARIGVAST.[ 6].LNPLLNEADYALYQNR.[4].EKTS 259  Alcanivorax sp. DG881

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