Conserved Protein Domain Family
Ubl_ZFAND4
?
cd01802: Ubl_ZFAND4 
ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar proteins
ZFAND4, also termed AN1-type zinc finger and ubiquitin domain-containing protein-like 1 (ANUBL1), may function as an oncogene that promotes proliferation and regulates relevant tumor suppressor genes in gastric cancer, suggesting a role in gastric cancer initiation and progression. ZFAND4contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal AN1-type zinc finger. Unlike ubiquitin polyproteins and most ubiquitin fusion proteins, the N-terminal Ubl domain of ZFAND4 does not undergo proteolytic processing.
Links
?
Statistics
?
PSSM-Id: 340500
Aligned: 19 rows
Threshold Bit Score: 104.333
Created: 9-Jun-2017
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
key conservedkey conserved
Feature 1: key conserved lysine K27, 1 residue position
Conserved feature residue pattern:[KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:K27 (Ub numbering) is a lysine conserved in the Ubl_ubiquitin_like family; it is one of 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering); may have other functions, for example for NEDD8 it is involved in the mechanism of protein neddylation
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 

Feature 1                                  #                                                   
Q86XD8        28 MELFIETLTGTCFELRVSPFETVISVKAKIRRLEGIPICRQHLIWNNMELENDYCL.[1].DYNISEGCTLKLVLAMR 101 human
XP_003387194 104 IDLTIEAVTGTVYDLCVSPFETILGIKTKIQKLEGIPVSQQHLIYGSTELMDDLCL.[1].ECHVRSGSQLKLVIAMR 177 Amphimedon queenslandica
ELU10002       1 MELYIETLTGTAFELRVSPYETIQDVKARIQKLEGIPMCQQHLIWRSIELEDDYSL.[1].DYSIHDGASLKLVLTMR 74  Capitella teleta
XP_006816684   4 MELFIETLTGTAFELRVSPFETIMSVKAKIQRLEGIPIAQQHLIWQSTELEDDYCL.[1].DYSITAGSTLRLVLAMR 77  Saccoglossus kowalevskii
XP_002115693   1 MELYVETLTGIAFELRVSPYETIIDVKAKIQKFEGIPISQQHLLWKSIELEDDYCL.[1].DYRITNGSTLQLVLSMR 74  Trichoplax adhaerens
KDR18236      20 MDLFIETLTGTAFEMTVSPFDTVMSIKSKIQRVEGIPVSHQHLLYNLKELDDSACL.[1].DYAIQDGATLKLVLSMR 93  Zootermopsis nevadensis
XP_013397692   1 MELYIETLTGAAFELRVSPFETIMSVKAKIQRLEGIPISQQHLIWQSVELEDDYCL.[1].DYSIHDGATLKLVLAMR 74  Lingula anatina
EKC31014       1 MELYIETLTGTFFELRVSPFETIMSVKAKIQRLEGIPIGQQHLIWQSIELEDDYCL.[1].DYSIHDGATLKLVLAMR 74  Pacific oyster
EEC10904       7 IEVFIETLHGTAFELLVSPADTVVSIKTRISRLEGIPVSQQHLIWQCQELPDESSL.[1].DCNITDGATLKLVLGMR 80  black-legged tick
CCD80370       1 MLIFIRGLSGAVTPLNVSPHESVLSIKIRIFYLKSIPTHDQHLLYSGVELTDQTIL.[1].TVNIGHGALLLLVLGLR 74  Schistosoma mansoni

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap