Conserved Protein Domain Family
PLAT_polycystin

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cd01752: PLAT_polycystin, with user query added  
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.
Statistics
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PSSM-Id: 238850
Aligned: 20 rows
Threshold Bit Score: 168.608
Created: 14-Sep-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

query      518 YYVSVTTGK.[ 4].ATDSRAFIFLIGEDDERSKRI.[1].L.[10].RGSVEEFYVAGL     DVGIIKKIELGHDGA 590 
Q9NTG1    1232 YLVTIFTGS.[ 4].GTRANVFVQLRGTVSTSDVHC     L.[ 9].RGSINTFLLTTK.[1].DLGDIHSIRVWHNNE 1303 human
XP_425128 1437 YLVTVFTGH.[ 4].ATTSKVTLTLYGLEGESEPHH     L.[ 9].RGGVDVFLLCTL.[1].PLGELQSIRLWHDNS 1508 chicken
Q09624    2184 YVIAVETGY.[ 4].TTDSTICFNLSGNEGDQIFRS     F.[13].WGTTDRFVMTTA.[1].PLGELEYMRLWLDDA 2259 nematode
XP_414854 3470 YEILVKTGW.[45].CTTAHVGIALYGVDNKSGHRH     L.[ 7].RNSLDVFQIATE.[1].NLGSIWRIRIWHDNK 3580 chicken
Q8TDX9    1798 YAVVIDTGF.[ 4].RLTSKVYIVLCGDNGLSETKE     L.[ 9].RNSRHTFILSAP.[1].QLGLLRKIRLWHDSR 1869 human
XP_691431  604 YLLSINTGQ.[ 4].STSSQVTVTLQGSEGESEPHH     L.[ 9].RGGLDLFLLTTP.[1].SLGELQSIRLWHDNS 675  zebrafish
XP_791253 2283 YEITVFTGM.[ 4].STTAKVSLIITGEAEESRPRL     L.[ 9].RGGIDSFIMSAP.[1].HLGNLLHLRIWHDNS 2354 purple urchin
XP_694302  505 YLVNVQTGH.[ 4].GTTAKIKVMLQFAEGQSDSYS     L.[ 9].RGGVDVFLLSMP.[1].SLGELQSIDISHDNS 576  zebrafish

query      591 S.[2].SCW     LVEEL.[8].TKYML.[1].CNCWLAK.[5].ITSRVF 633 
Q9NTG1    1304 G.[2].PSW.[5].KVENL.[4].IWLFI     CQKWLSV.[2].TLDRTF 1343 human
XP_425128 1509 G.[2].PSW.[5].LVHDL.[4].KWYFL     CNSWLAV.[5].VLDKVF 1551 chicken
Q09624    2260 G.[4].ESW.[5].IVKDL.[4].IYYFP     FNNWLGT.[5].ETERLA 2304 nematode
XP_414854 3581 G.[2].PSW.[5].IVRDL.[4].SYFFL     VNDWLSV.[7].MVEKEV 3625 chicken
Q8TDX9    1870 G.[2].PGW.[5].MVKEL.[4].GWFFP     AQCWLSA.[5].RVEREL 1912 human
XP_691431  676 G.[2].PAW.[5].TVQDL.[4].KWHFL     CNSWLSI.[5].TLDKVF 718  zebrafish
XP_791253 2355 G.[2].PSW.[5].VIKDL.[4].MYFFM     CDRWLAV.[5].QIERVI 2397 purple urchin
XP_694302  577 G.[2].PDW.[5].MIQDL.[4].VSHFL     CSTWLRG.[1].TCKRTF 615  zebrafish
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