Conserved Protein Domain Family
LCAD

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cd01160: LCAD 
Long chain acyl-CoA dehydrogenase
LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.
Statistics
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PSSM-Id: 173849
Aligned: 5 rows
Threshold Bit Score: 604.108
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:FAD binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to other acyl-CoA dehydrogenases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                                                                    
ZP_00031355  18 EEHSMLRDVIRRFIAKEVLPFADQWEING.[3].RELLRKMGEQGFL.[4].SEAFGGA.[3].VLGTVVLAEELGR 89  Burkholderia fungorum
NP_767621    39 AEHDAFRDVMRRFVEKEISPFAHEWDEAG.[3].RALYRKAAEIGLL.[4].PEEYGGI.[3].QFMKIVASQELAQ 110 Bradyrhizobium japonicum...
AAH44447     67 EEHDLFRQNVRRFFQEEVAPYHAQWEKAG.[3].REVWEKAGEHGLL.[4].PEEHGGI.[3].LLSAAIVWEEQMY 138 zebrafish
P28330       55 PEHDIFRKSVRKFFQEEVIPHHSEWEKAG.[3].REVWEKAGKQGLL.[4].AEHLGGI.[3].LYSAAIVWEEQAY 126 human
NP_630859    10 PDHEAFRDTVRAFLAKEVAPHHQRWERNG.[3].REVWYSAGRQGLL.[4].DQEYGGG.[4].FRYSAVLIEEFAR 82  Streptomyces coelicolor ...

Feature 1                                                               # ##    ##              
ZP_00031355  90 .[2].FGGFAITVLVHT.[1].MASPHLQHAGNPAQLERLMPDLVAG.[1].KIAAVAMTEAGAGSDLASMRTTARLDGD 158 Burkholderia fungorum
NP_767621   111 .[2].AGGVSASLMSHT     IGSPPIARAARPEVKARVLPQVLAG.[1].KISALAITEPGGGSDVANLRTRARRDGD 178 Bradyrhizobium japoni...
AAH44447    139      SNCSGPGFSLHS.[1].IVMPYISHYGSKAQIERYIPQMAAG.[1].CIGAIAMTEPGAGSDLQGAKTFAKKDGT 205 zebrafish
P28330      127      SNCSGPGFSIHS.[1].IVMSYITNHGSEEQIKHFIPQMTAG.[1].CIGAIAMTEPGAGSDLQGIKTNAKKDGS 193 human
NP_630859    83      AGASGLALSLHN.[1].IVGPYLTRLATEEQKRRWLPGFVSG.[1].IVTAIAMTEPGAGSDLQGIRTTATDRGD 149 Streptomyces coelicol...

Feature 1                # #                                                                    
ZP_00031355 159 HYVLNGAKMFITNG.[1].HGDIYFVAAKT.[7].GGISMFIVEK.[3].GFSVAR.[1].LSKQGWLSSDTAELVFDEC 230 Burkholderia fungorum
NP_767621   179 HYVVSGEKTFITSG.[1].RADYLTVAVRT.[5].GGVSLLLIAG.[3].GLSRTK     LKKMGWWASDTATLHFDDC 247 Bradyrhizobium japoni...
AAH44447    206 DWILNGSKVFITNG.[1].MSDVVIVVAVT.[8].HGISLFLVDR.[3].GYQKGR.[1].LEKLGLKAQDTAELFFEDV 278 zebrafish
P28330      194 DWILNGSKVFISNG.[1].LSDVVIVVAVT.[8].HGISLFLVEN.[3].GFIKGR.[1].LHKMGLKAQDTAELFFEDI 266 human
NP_630859   150 HYLLNGSKTFISNG.[1].LADLVVVVART.[6].AGQSLLVVER.[3].GFERGR.[1].LAKIGQQAQDTAELFFNDV 220 Streptomyces coelicol...

Feature 1                                                                                       
ZP_00031355 231 RVPV.[2].LLGEENKGFYSLVRNLQNERITLGAQALGEASRAIEITLDYVTQRTAFGQTLWEKQAIRQKMAMLLAKVEA 307 Burkholderia fungorum
NP_767621   248 RVPA.[2].LIGEEGQGFKIIMQNFNSERMGMAAGCTAFARVCLDEAIAYAKERKTFGKPLAQHQVIRHKIVDMAQKVAA 324 Bradyrhizobium japoni...
AAH44447    279 RLPA.[2].LLGQVNKGFYYLMNELPQERLLIAVMGLASCEFMFEESRNYVMQRKAFGRTIADLQVVQHKLAELKTEICV 355 zebrafish
P28330      267 RLPA.[2].LLGEENKGFYYIMKELPQERLLIADVAISATEFMFEETRNYVKQRKAFGKTVAHLQTVQHQLAELKTHICV 343 human
NP_630859   221 HVPK.[2].LLGEENRAFTYLMGNLAQERLAIAVGAAAATEEILDITTRYVKEREAFGRPLAKLQHVRFEIAEMATEAAV 297 Streptomyces coelicol...

Feature 1                                                                        #      # #     
ZP_00031355 308 ARQLLYNTAWRDAQ.[4].VAEVSMIKALCGELVNEVMYACQQFHGGFGYMR.[3].IERMVRDARVQSIGGGATEVMLE 384 Burkholderia fungorum
NP_767621   325 SQAMLEMLAWRLEQ.[4].VAEICMMKNQATQTMAFCASEAVQIFGGAGFMR.[3].AERIYREVKVNAIGGGTEEIMKD 401 Bradyrhizobium japoni...
AAH44447    356 GRAFIDSCLQLHSE.[4].SSTASMAKYWATDLQNRVATQCLQLHGGWGYMW.[3].IAKAFADARVQPIYGGTNEIMKE 432 zebrafish
P28330      344 TRAFVDNCLQLHEA.[4].SATACMAKYWASELQNSVAYDCVQLHGGWGYMW.[3].IAKAYVDARVQPIYGGTNEIMKE 420 human
NP_630859   298 TRTFLDRCVTEHVA.[4].PVHASMAKWWATELQKRVVDRCLQLHGGYGYMS.[3].VARAFLDGRIQTIYGGTTEIMKE 374 Streptomyces coelicol...

Feature 1              
ZP_00031355 385 EVAKRMV 391 Burkholderia fungorum
NP_767621   402 LASRQMG 408 Bradyrhizobium japonicum USDA 110
AAH44447    433 LISRNIV 439 zebrafish
P28330      421 LIAREIV 427 human
NP_630859   375 IIGRSLL 381 Streptomyces coelicolor A3(2)

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