1QUU,1CUN


Conserved Protein Domain Family
SPEC

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cd00176: SPEC, with user query added  
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here
Statistics
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PSSM-Id: 238103
Aligned: 170 rows
Threshold Bit Score: 54.374
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
linker region
Feature 1:linker region
Evidence:
  • Comment:may form stabilizing contacts that favor dimerization
  • Comment:dimerization occurs in an antiparallel fashion

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                                                           ######  
query     4486 VSKQVKTCKTAQASL.[2].YQNEVTGLCAQGREL.[11].VLGKLQELQTVYDTVLQKCSHRLQELEKSLVSRKHF 4564
1QUU_A      50 VRALLRKHEAFESDL.[2].HQDRVEQIAAIAQEL.[10].VNDRCQKICDQWDRLGTLTQKRREALERMEKLLETI 127  human
7508957    435 IKALRKRHEAFESDL.[2].HQDRVEQIAAIAREL.[10].INARCQAICSQWDRLGQLSSKRRETLEDAERIAERL 512  Caenorhabditis elegans
2493434    563 VEDLLQKHTLVEADI.[2].QAERVRGVNASAQKF.[14].IRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFF 644  human
2493433    290 VQALLRKHEGLERDL.[2].LEDKVKALCAEADRL.[10].IQVKREELITNWEQIRTLAAERHARLNDSYRLQRFL 367  human
134795    1533 IQSKHQKHQAFEAEL.[2].NADRIQSVLAMGGNL.[12].VQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYI 1612 fruit fly
267024     559 VEDLLQKHSLVEADI.[2].LGERVKVVVQNSQKF.[15].IVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFY 641  fruit fly
267024    1840 VSTLQRKHYNFLQDL.[2].LYSQVQQIQEESAKL.[11].ITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFF 1918 fruit fly
7505762    512 VEAATKKHEAIETDI.[2].YEERVQAVVAVAGEL.[10].INERKENVLQLWNYLFQLLLARRVRLELSMAIQKIF 589  Caenorhabditis elegans

Feature 1                                                                                      
query     4565 .[1].ED.[ 5].HWLKQADIVTFP.[11].HAQLDKYQSILEQS.[2].YENLLLTLQTTGQAMLP.[13].LSALPQQ 4648
1QUU_A     128      DQ.[13].NWMEGAMEDLQD.[10].QSLITAHEQFKATL.[2].ADGERQSIMAIQNEVEK.[19].MDELRTK 223  human
7508957    513      DS.[13].NWLDGAREDLAD.[10].EELVNAHDQFKSTL.[2].ADREFSSINQIEHEVEH.[20].ASDIRRK 609  Caenorhabditis elegans
2493434    645      WE.[ 5].GWIREKEKILSS.[10].MRLLSKHRAFEDEM.[2].RSGHFEQAIKEGEDMIA.[12].IIYIREQ 725  human
2493433    368      AD.[ 5].SWVTEMKALINA.[10].EALLDRHQEHKGEI.[2].HEDSFKSADESGQALLA.[12].LTVLSEE 448  human
134795    1613      AA.[ 5].FWLGEVESLLTT.[10].QNLMKKHQLVEADI.[2].HEDRIKDMNNRADSLVE.[12].RQSINER 1693 fruit fly
267024     642      WD.[ 5].NWIKEKEQIVST.[10].NLMLSKHKALESEI.[2].HDPQLQNVAKVGSELIT.[12].LKEILNK 722  fruit fly
267024    1919      NM.[ 5].IWMEDLVRQMNT.[10].ELLMNNHQSLKAEI.[2].REDNFGACISLGKELLT.[23].LRRWEER 2010 fruit fly
7505762    590      HD.[ 5].DLMDDIKSRLLS.[10].EDLLQKHALLESDI.[2].IGERVNNSIAQAQRFRN.[20].SDVLQKR 678  Caenorhabditis elegans

Feature 1                 
query     4649 FNVIVALAKDK 4659
1QUU_A     224 WDKVKQLVPIR 234  human
7508957    610 WGEVQNSVPRR 620  Caenorhabditis elegans
2493434    726 WANLEQLSAIR 736  human
2493433    449 RAALLELWELR 459  human
134795    1694 YERICNLAAHR 1704 fruit fly
267024     723 WDHLLDLTKYR 733  fruit fly
267024    2011 WENLQLILEVY 2021 fruit fly
7505762    679 YKELLDLAAER 689  Caenorhabditis elegans

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