Conserved Protein Domain Family
T6A_TsaD_YgjD
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TIGR03723: T6A_TsaD_YgjD 
tRNA threonylcarbamoyl adenosine modification protein TsaD
This model represents bacterial members of a protein family that is widely distributed. In a few pathogenic species, the protein is exported in a way that may represent an exceptional secondary function. This model plus companion (archaeal) model TIGR03722 together span the prokaryotic member sequences of TIGR00329, a protein family that appears universal in life, and whose broad function is unknown. A member of TIGR03722 has been characterized as a DNA-binding protein with apurinic endopeptidase activity. In contrast, the rare characterized members of the present family show O-sialoglycoprotein endopeptidase (EC. 3.4.24.57) activity after export. These include glycoprotease (gcp) from Pasteurella haemolytica A1 and a cohemolysin from Riemerella anatipestifer (GB|AAG39646.1). The member from Staphylococcus aureus is essential and is related to cell wall dynamics and the modulation of autolysis, but members are also found in the Mycoplasmas (which lack a cell wall). A reasonable hypothesis is that virulence-related activities after export are secondary to a bacterial domain-wide unknown function. [Protein synthesis, tRNA and rRNA base modification]
Links
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Statistics
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PSSM-Id: 274748
Aligned: 137 rows
Threshold Bit Score: 384.855
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

WP_012245105   5 ILGIESSCDETGVGIVR     GT.[1].LLANTVSSSMAEHVRFGGVIPEIASRAHLDAMVPTLNEA.[5].VTLDEID 75  Renibacterium salmon...
WP_011577240   2 ILSIESSCDDSSLALTR.[3].AK     LIAHFKISQEKHHSSYGGVVPELASRLHAENLPLLLERI.[5].KDFSKLK 74  Helicobacter acinony...
WP_011113714   6 ILGIESSCDDLSIAIAI.[1].NK     IVTTKTKSSSSVHANYGGVVPEIAARYHEEILHQTLNEA.[5].LTINKID 76  Mycoplasma gallisept...
WP_011371767   2 ILSIESSCDDSAIAITE.[3].NR     LLFHKKISQELEHSVYGGVVPELAARLHAEALPRILEEC.[1].PYFKDLK 70  Sulfurimonas denitri...
WP_011206487   3 ILGIETSHDDASVALFS.[1].NK     VEILLTISQFELHEQFGGTVPELASREHSRNLAIILEKL.[4].IDFSTID 72  Mycoplasma hyopneumo...
WP_012498495   3 IFAIESSHDDTSFALLD.[1].NK     PIWMKTITQTEIHKQYGGTVPEIASRLHVKNIGILIEDI.[3].ININKID 71  Mycoplasma arthritidis
WP_010924922   3 ILGIETSHDDTSIAIIE.[1].GK     ILKMITWSQSDFFAQYGGTIPELSSRQHSQNIIRIIDKL.[3].FDFSKID 71  Mycoplasma pulmonis
WP_011264650   3 ILGIESSHDDTSIAILE.[1].KK     VLFQLSLSQVKTHEKFGGTIPEIASREHVKNINILLTML.[3].FDLSKLD 71  Mycoplasma mobile
WP_011139420   2 ILSIESSCDDSSIAITR.[3].RA     ILFHKKISQDSAHSPHGGVVPELASRLHAVALPKILEEC.[1].PFFPRLK 70  Wolinella succinogenes
WP_011183382   3 ILAIESSCDEFSISIID.[1].GK     ILTNIISSQIDQHVNFGGVVPELAARLHLENISWVIKSA.[5].TKIEEID 73  Mesoplasma florum


WP_012245105  76 AIAVTAGPGLAGALMVGVCAAKALSLATGKPLYAINHLVAHVGVGLLD.[5].ESGELP.[1].NLG.[1].LLVSGGHT 147 Renibacterium salmon...
WP_011577240  75 AIAITNQPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFIN.[1].KKTCMP     LSV     LLVSGGHS 140 Helicobacter acinony...
WP_011113714  77 LITYTENPGLLNCLHVAKVFANTLGYLLKIPAQGINHLYGHIFSPMID.[8].SDLIYP     ALG     IVVSGGHT 149 Mycoplasma gallisept...
WP_011371767  71 AVAVTTTPGLSVTLVEGVTMAKAISIALNIPIIGVNHLVGHIYSLFIE     KESYFP     LTV     LLVSGGHT 135 Sulfurimonas denitri...
WP_011206487  73 AIAYTKNPGLIGPLKIGFLFASALSLFFNKPLIPIDHLLGHFWSAAIE     NDLEFP     VLS     LLISGGHT 137 Mycoplasma hyopneumo...
WP_012498495  72 LIAYTKEPGLVGSLHVGYVVAQSLALILNKKIVGLNHLEGHFYSAFIG     KEVIYP     ALG     LLVSGGHS 136 Mycoplasma arthritidis
WP_010924922  72 AIAYTEKPGLIGTLQIGFLVAQALSRVLKIKAYPIDHIEGHFFSASFE     KNYLFP     ALA     LIVSGGHS 136 Mycoplasma pulmonis
WP_011264650  72 YIAYTEKPGLIGALQIGFLFASALSISLNKKLIPINHLEAHFFSSEIT     NEILYP     AVG     LVVSGGHS 136 Mycoplasma mobile
WP_011139420  71 AIAVTNEPGLSVTLLEGVMMAKALALALHLPLIAVNHLKGHLYSLFLE     QESRFP     LDV     LLVSGGHT 135 Wolinella succinogenes
WP_011183382  74 HVAYTEKPGLIGSLIIGKLVAETIASYIDKPLMPLHHIEGHIYGASIE     NEFVYP     VLA     MVVSGGHT 138 Mesoplasma florum


WP_012245105 148 EILRVRSLT.[1].DVELLGATIDDAAGEAFDKIARILGLDYPGGPAIDRLARE.[1].DPR.[3].FPRGLTA.[14]. 225 Renibacterium salmon...
WP_011577240 141 LILEARNYE     DIKIMATSLDDSFGESFDKVSKMLNLGYPGGPVIEKLALD.[1].AHK.[5].FPIPLKN.[ 3]. 208 Helicobacter acinony...
WP_011113714 150 AIYDVQSPS     KITLLDETLDDAIGEVYDKVGRALGLQYPAGAKIDQLYNP.[1].QAE.[3].FLKTNKL       212 Mycoplasma gallisept...
WP_011371767 136 QVMEVKSFT     EIKTVAKSMDDSFGESFDKVAKMMNLGYPGGPVIEALAKG.[1].DRK.[3].FTVPLFQ.[ 3]. 201 Sulfurimonas denitri...
WP_011206487 138 QLIFAENKN     NLEIIGSTVDDALGEIYDKIGRSLGCGYPGGPKIDLIWQQ.[4].NME.[3].FSLPKVL.[ 3]. 206 Mycoplasma hyopneumo...
WP_012498495 137 QLVLYNSKD     DFKIIGQTQDDAVGEVYDKVARKLNLGFPGGPLIDQIWKN     NHK.[5].LTIPKTE.[ 2]. 202 Mycoplasma arthritidis
WP_010924922 137 QLMLAKDKD     NIEVIGSTLDDAIGEVFDKVATKLNLGFPGGPKIEALCKD.[1].DFD.[3].LTKPKTQ.[ 2]. 201 Mycoplasma pulmonis
WP_011264650 137 LIYYVKNVN     SLEIIGETLDDAIGEVFDKISRKLNLGFPGGPIIDRISSE.[3].DIK     FTIPKTE.[ 2]. 200 Mycoplasma mobile
WP_011139420 136 MVLHARSFG     EIEIIGQSMDDSFGESFDKVAKMLSLGYPGGPIVESYAKE.[1].DAS.[3].LPLPLAG.[ 3]. 201 Wolinella succinogenes
WP_011183382 139 QIEIVNSPN     EFEVIGATLDDAIGECYDKVARVMGLGYPGGPKIDKLAQK.[1].NKE.[3].FPISKND.[ 2]. 203 Mesoplasma florum


WP_012245105 226 YDFSFSGLKTAVARRVEQ.[11].NIAASFQEAVLDGITSKAVLACR     EQGL     ETLFLGGGVAANSRLRALL 300 Renibacterium salmon...
WP_011577240 209 LAFSFSGLKNAVRLEIEK.[11].KIGYHFQSVAIEHLIQQTKRYFK     TKRP     KIFGIVGGASQNLVLRKAF 283 Helicobacter acinony...
WP_011113714 213 SAFSYSGFKSAVLRYIEL.[10].QAVSSFQKFIIDDFIDRIKNVIN     KADS.[2].QTILLGGGVSANSYLRSEL 288 Mycoplasma gallisept...
WP_011371767 202 IAFSYSGLKNSVRLAVEA.[ 7].DIAASFEHIATAHIIQKLKKYFK     EVPP     KTFAIVGGASANLYLRSSI 272 Sulfurimonas denitri...
WP_011206487 207 LDFSFSGLKTQVINYTNN.[13].EIAVSFQKTVIKYLKRQLDLALK.[1].KKNV     KTITLVGGVAANSEIRKLI 284 Mycoplasma hyopneumo...
WP_012498495 203 FDFSFSGIKTNVINLINN.[11].QIATEFQNTIVEYLKEHMETAIK     KFSP     KCIVLAGGVSANFAIREMF 277 Mycoplasma arthritidis
WP_010924922 202 FDFSFSGMKSQVINLANQ.[ 6].NLACSFQKEAVDYLLEKTKKCLE     KYKI     NSLILGGGVAANFLLREGF 271 Mycoplasma pulmonis
WP_011264650 201 LDFSFSGIKTQVINYINN.[ 7].NVASSFQKTTIDYIEEKLKLAIK     KHHP     QSLVVGGGVSANTELRKRL 271 Mycoplasma mobile
WP_011139420 202 VAFSFSGLKNAVRLVIQS.[11].DICASFQATAIAHLIQKCRLYLA     TSNA     PYLAIVGGASANLALREEM 276 Wolinella succinogenes
WP_011183382 204 YDFSYSGLKTAVINIIHN.[11].DIAASFQYAATKIVEKKLEKAII     QFKP     KTLTVAGGVSANSEIRNII 278 Mesoplasma florum


WP_012245105 301 AER.[7].LLVPGISLCTDNGAMVAALGAQLVQ 335 Renibacterium salmoninarum
WP_011577240 284 ENL.[7].LVLAPLEFCSDNAAMIGRSSLEAYQ 318 Helicobacter acinonychis
WP_011113714 289 KEL.[3].TLVPKPIYSGDNAAMIINYAQYLLN 319 Mycoplasma gallisepticum
WP_011371767 273 EEL.[7].LLLSELKYCSDNAAMIGRVAVEMYK 307 Sulfurimonas denitrificans
WP_011206487 285 KTY.[5].VVIPKKEFCTDNGAMIAKAAQIFLK 317 Mycoplasma hyopneumoniae
WP_012498495 278 YSL.[3].VFLPDLEYTTDNAMMIARLAYEKFR 308 Mycoplasma arthritidis
WP_010924922 272 KKL.[3].VYIPSKELATDNAAMIAKVLYEKLK 302 Mycoplasma pulmonis
WP_011264650 272 STL.[3].VLFPKKEYTTDNGAMIAITAFLKLN 302 Mycoplasma mobile
WP_011139420 277 ERL.[7].LLLAPLAYCSDNAAMIGRAALESYA 311 Wolinella succinogenes
WP_011183382 279 MSL.[8].TFVPKMEYCTDNAAMIAKLAYEKLK 314 Mesoplasma florum
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