Conserved Protein Domain Family
SMC_prok_A
?
TIGR02169: SMC_prok_A, with user query added  
chromosome segregation protein SMC, primarily archaeal type
SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Links
?
Statistics
?
PSSM-Id: 274009
Aligned: 11 rows
Threshold Bit Score: 1043.88
Created: 8-Oct-2014
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 

query         252 HALGPLLNAYQENLLEKQELI.[2].YEQEMADFSNRCKQILTENEIMHKEVEELKSECDRYTKEIQKMVENTA.[14]. 336 
AAM07677      713 FELSRKIRDCEASISRKELEL.[2].IAGREAKLAELLEAKQADLRAIEEARTELRAEMDRVIAEKAEKEAVAS       783  Methanosarcina ace...
AAL81967      813 FELRIKLSDEKKELELASKDL.[2].LLEEENAVKEEIEESERKIQEIEQKIENEKSELAKLRGRIQRLERKKE       883  Pyrococcus furiosu...
BAC09477      708 NALSQALSEAHQSHRDRQRQW.[2].LQQQQQQLNRQQAELERQQQYLSQELTAAETELTHLEARLPELEAELA       778  Thermosynechococcu...
BAC91263      702 HELQSAAEAAQRELVAIENRA.[2].LGREHSTQQARATQLRVFLDSCQVGLEADRQEQADLAARLGPLREQIV       772  Gloeobacter violac...
CAC11918      682 DQAFSEMSEASRRTGEIMKEQ.[2].LKKEAERSREELKQVMDDISSTDRAIADKKRMIDENEKVIEQKTLDLH       752  Thermoplasma acido...
BAB59963      680 DEALQSMSDASKKTGEIEKER.[2].INDDLAKNKQILKDIASELSKLKQEIAENKEEKEALEKDISDRQLDLH       750  Thermoplasma volca...
WP_010879055  701 KQYKDEVDRLTGMISELRNRI.[2].LDEKIRTESGRIEELREKISQKSREKENYISSLKDYNSKLAEMEEAIG       771  Archaeoglobus fulg...
WP_010902208  724 DSARDRRQDATEQVRTIQADI.[2].AEADREAAVERIADLETRIEELQDEREAVDAEMQTVDAEIDAQQETIA       794  Halobacterium sali...
WP_010880376  694 SEKTALLKVSERKIEELSSEG     LEQYEEKFKEKLENSKEYLKILEEKLLNVEDKLKELAEEIEYYEEKLN       762  Aquifex aeolicus


query         337 NIKRETNDIRSSY     ESKIEVILKCNEALKKEHTITVSELSNLRGKYEILS.[4].EMRNKEQQ.[10].IEECKIL 414 
AAM07677      784 ELEDQVAELEAKL.[1].DSPLPEINKKAEFVDEEIRRLEGRIRDTEASLNALQ.[8].KIAEAKEL      IRELDEK 856  Methanosarcina ace...
AAL81967      884 KLKKALENPEARE.[1].MEKIRIIDGEISSLKEELSRIESRIESLESRLNEEL.[9].EIEGLVNK      INALKNN 957  Pyrococcus furiosu...
BAC09477      779 AERLALNALEASP.[1].HQQWQQVQAQLQAQEKIHASQVAALQAVDQALGDRH.[9].LKQTEQEI      QRLCQAQ 852  Thermosynechococcu...
BAC91263      773 QVREELAKLEQSD.[1].HHRWQQSQQHLRELETEVRRWELQLRHAEADLQKSH.[8].KRQNLLSR      RLDWEDQ 845  Gloeobacter violac...
CAC11918      753 KYQEALNDLYDRI.[1].PEFFKNIGDLSNEINEVRSEIDAVASELNQITSRRD.[4].ERKHLEDQ      MIDTKLQ 821  Thermoplasma acido...
BAB59963      751 KYQEALNDIYDDL.[1].QSIIDTIENSMRKLEDYRKKISAITADIEVKEKRVS.[4].ESNNIVQQ      NIELEIQ 819  Thermoplasma volca...
WP_010879055  772 ELEAEIEEIERML.[1].GSEVPKIVEELDKIKEEHQRNREILISIEKKIESLE.[8].SMQEKQVY      LDEIKDR 844  Archaeoglobus fulg...
WP_010902208  795 AIEAEIESLEAEL.[1].ESRIPELTAEKEDIEATVVDLEGRVDELDGELNSLT.[8].AVEDLQAD      VADAESR 867  Halobacterium sali...
WP_010880376  763 NLKLKEGDIKRHY.[1].REGVEEKRREYSKVRKQVSEIEKSLNEIERELNKKT.[8].EIQEKERE      REYLTER 835  Aquifex aeolicus


query         415 LDELKYQYENEKR.[5].IKHIEEIQPENEKKLIMVIAERNHLKGLVNNLETTLKRTQRKSEQMQSLVYS.[4].RNSLK 493 
AAM07677      857 KASRREKVDSLKA.[1].IAELEARLEEKQNRELQLSDELIGLQKERENVQAEYSAVKRRVNTASTTLEK.[4].VLTLT 931  Methanosarcina ace...
AAL81967      958 ISENEKALELLNK.[1].LEKLKSIEENIKGEIRTLREKRKKLEEDISKLREKKEVLQRKLQELEIEANT.[4].DAQLN 1032 Pyrococcus furiosu...
BAC09477      853 REMRCQQQALDQT     LGDLATQIERTQAALRELDSRLGHLKGDRDRHEYQLRQQQKNYQQLEWQYQK     ASETL 922  Thermosynechococcu...
BAC91263      846 KVEFGQREEESRT.[1].LAEFDRVIAELAAQVAELEERLVDIKRERDRLEAHGRALQQRQGQLNLQREQ.[4].QGQRA 920  Gloeobacter violac...
CAC11918      822 ENSIAAEIDDLNG.[1].KRELEEKAKKYQYALNDLEGRYGNLSAQVREADKQIREMENGINDAKASIDL.[4].MNDLK 896  Thermoplasma acido...
BAB59963      820 RKAVEDEIHNIEI.[1].KRSMEEELKKHELFLKQLESSHSDIASKIKDMENEMKEIRSKIEEINSDVEI.[4].LSELK 894  Thermoplasma volca...
WP_010879055  845 IDEIRRTIEEGKA.[1].VEEINSELEELRKEERELGKELKGLRKERDELIKQLRNAEEEKRKIEAEIDR.[4].IKLQK 919  Archaeoglobus fulg...
WP_010902208  868 KADEQARIEALNG.[1].IEAKQAELAEKEAAVEDLEAELADLKRDREERKADLSEAEDARDEQAAAVED.[4].LERLQ 942  Halobacterium sali...
WP_010880376  836 IKSLKKEIENLIL.[1].KEKTLQEVKEAEVKVYDYIKQKEELEKEILNLKSKLGKLKIKEEELKEKIFE.[4].LKVLE 910  Aquifex aeolicus


query         494 EKLSKV.[4].EELFSEYE.[5].REKL.[6].TEKENANMDRLGKSITS.[8].LEIVRKGTKQQVDSVEKRIK 571 
AAM07677      932 ATKSAL     FDQEKQLL.[6].GIEE.[6].YETVYMRIQAIEEAMRR     LEPVNMRAIDEYKEVELRLS 998  Methanosarcina acetivor...
AAL81967     1033 AQLEEK     KYQLTHYD.[6].IKEI.[3].LEKVKKEIEKMEEEIRS     LEPVNMKAIEDFEIVERRYL 1096 Pyrococcus furiosus DSM...
BAC09477      923 TTLQAQ     LQELSTIE.[6].PLPE.[6].LRDIQQQCQALEQRLRA     MEPVNMLAIQEFEETQARLK 989  Thermosynechococcus elo...
BAC91263      921 AALAAA     QERLDELG.[4].DVPP.[6].LEQLQATRLRKQRRLEA     LEPVNMLAIEEYDRTAERQG 985  Gloeobacter violaceus P...
CAC11918      897 VKAGIL     EGNLSSIE.[2].LSSY.[6].IGDLQAMRQEIERAIMD     LGEINNAAPQQYEDALKDLD 959  Thermoplasma acidophilum
BAB59963      895 VKRSVV     ADRNSAIE.[2].MQSI.[6].EGDIVLEKRKCEADISA     LGDINNGAIQEYEESVKAYN 957  Thermoplasma volcanium ...
WP_010879055  920 ERLEIA     ESEIAEIG     EVEV.[6].LEKVEKVLDEVLVELST     FGDVNLKAIQEYEEVKARRD 980  Archaeoglobus fulgidus
WP_010902208  943 AAAQTL     SEEVAELD.[3].GEYD.[6].ADVVAENVERLGARMEA     LEPVNMLAIDEYESVADTLD 1006 Halobacterium salinarum
WP_010880376  911 EKIENL     NEELKEYE.[6].DEES     IPKLKEKLKRVTEEIQK     LGSVNFRAEEDYAEELKRFN 971  Aquifex aeolicus


query         572 .[11].DYQRKIQHLNDIIKEQEDVIKKLQKEKYSS 612 
AAM07677      999       DLQGKRDTLFTEREQLLERIDQYEQLKRDA 1028 Methanosarcina acetivorans C2A
AAL81967     1097       ELKSKREKLEAEKESIIEFINEIEKEKKNV 1126 Pyrococcus furiosus DSM 3638
BAC09477      990       ELQEKLAVLAAERTEILLRIENFTTLRHQS 1019 Thermosynechococcus elongatus BP-1
BAC91263      986       ELSEKLATLQRERSELLLRIEDCDTLKRSA 1015 Gloeobacter violaceus PCC 7421
CAC11918      960       DYEKKHEKLMEEKKALEETTAMLNEKKREV 989  Thermoplasma acidophilum
BAB59963      958       ELKDKKNRLELERRSLQDLTDSLNKKKKEV 987  Thermoplasma volcanium GSS1
WP_010879055  981       ELVEKKMVLEKERADILDRIEKYERMKREI 1010 Archaeoglobus fulgidus
WP_010902208 1007       SLEAQRATLTEEADGIRERIARYDEQKKST 1036 Halobacterium salinarum
WP_010880376  972       DYKEKQQKLKEESKAIKKLIEETENKKRKV 1001 Aquifex aeolicus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap