New Search Structure Home MMDB Conserved Domains PubChem PubMed Entrez BLAST Help Structure related to [gi|30124074|ref|NP_828849.2|] orf1ab polyprotein (pp1ab) [SARS coronavirus] 17 Low redundancy structures identified View  All similar MMDB Non-identical High redundancy Medium redundancy Low redundancy  sequences, sort by  BLAST E-value BLAST bit score Sequence Identity Aligned Length  and display as  graphic table  at  sequences per page Go « Previous page Jump to page of Next page » Structures    E-value    1e-125 1e-125 1e-125 1e-111 1e-100 1e-77 1e-71 1e-71 1e-66 1e-65 1e-64 1e-44 1e-08 1e-06 0.010 0.010 0.010 « Previous page Jump to page of Next page » References: Wang Y, Addess KJ, Chen J, Geer LY, He J, He S, Lu S, Madej T, Marchler-Bauer A, Thiessen PA, Zhang N, Bryant SH (2007), MMDB: annotating protein sequences with Entrez's 3D-structure database, Nucleic Acids Res. 35:(D)298-300. Help | Disclaimer | Write to the Help Desk NCBI | NLM | NIH

28847 cd02907 Macro_Af1521_BAL_like Macro domain, Af1521- and BAL-like family 8,1021,9,9,1034,18,54,1088,73,10,1098,86,15,1113,108,10,1124,118,10,1138,128,13,1151,143,19 false 140369 cl00019 Macro Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases) 0 115147 pfam06471 NSP11 NSP11 6,5898,0,41,5939,44,9,5949,53,161,6111,214,133,6245,347,16,6264,363,235 false 115147 pfam06471 NSP11 NSP11 -1 115154 pfam06478 Corona_RPol_N Coronavirus RPol N-terminus 4,4380,0,11,4392,11,38,4434,49,197,4631,247,105 false 115154 pfam06478 Corona_RPol_N Coronavirus RPol N-terminus -1 117288 pfam08715 Viral_protease Papain like viral protease 7,1540,0,70,1610,73,17,1629,90,97,1726,188,60,1786,251,15,1803,266,20,1825,286,34 false 117288 pfam08715 Viral_protease Papain like viral protease -1 114150 pfam05409 Peptidase_C30 Coronavirus endopeptidase C30 3,3268,0,217,3487,217,22,3510,239,33 false 114150 pfam05409 Peptidase_C30 Coronavirus endopeptidase C30 -1 117290 pfam08717 nsp8 nsp8 replicase 1,3919,0,198 false 117290 pfam08717 nsp8 nsp8 replicase -1 117942 pfam09401 NSP10 RNA synthesis protein NSP10 2,4237,0,96,4334,96,28 false 117942 pfam09401 NSP10 RNA synthesis protein NSP10 -1 117283 pfam08710 nsp9 nsp9 replicase 3,4117,0,19,4138,19,41,4180,60,50 false 117283 pfam08710 nsp9 nsp9 replicase -1 117289 pfam08716 nsp7 nsp7 replicase 1,3836,0,83 false 117289 pfam08716 nsp7 nsp7 replicase -1 128665 smart00382 AAA ATPases associated with a variety of cellular activities 5,5580,6,17,5597,25,43,5647,68,11,5669,79,8,5680,87,33 false 142146 cl09099 ABC_ATPase ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules -1 115136 pfam06460 NSP13 Coronavirus NSP13 2,6776,0,213,6989,215,83 true -1 31309 COG1112 COG1112 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair] 9,5623,445,12,5637,457,45,5684,502,30,5714,534,17,5733,551,50,5783,608,12,5795,633,26,5821,664,29,5850,699,32 true -1

ADP-ribose binding site 0 9 9 false 28840 cd02749 Macro

195629 45004 2H2Z_A Chain A, Crystal Structure Of Sars-Cov Main Protease With Authentic N And C-Termini 145579492 1 161978 38253 2FE8_A Chain A, Sars Coronavirus Papain-Like Protease: Structure Of A Viral Deubiquitinating Enzyme 93279494 1 174870 40997 2H85_A Chain A, Crystal Structure Of Nsp 15 From Sars 114794253 1 150984 36090 2AHM_G Chain G, Crystal Structure Of Sars-Cov Super Complex Of Non- Structural Proteins: The Hexadecamer 83753996 1 157880 37505 2ACF_D Chain D, Crystal Structure Of Adrp Domain Of Sars Nsp3 90108687 1 174075 40869 2FYG_A Chain A, Crystal Structure Of Nsp10 From Sars Coronavirus 114793880 1 264951 62212 2JZD_A Chain A, Nmr Structure Of The Domain 527-651 Of The Sars-Cov Nonstructural Protein Nsp3 167013232 1 264952 62213 2JZE_A Chain A, Nmr Structure Of The Domain 527-651 Of The Sars-Cov Nonstructural Protein Nsp3, Single Conformer Closest To The Mean Coordinates Of An Ensemble Of Twenty Energy Minimized Conformers 167013233 1 103709 26498 1QZ8_A Chain A, Crystal Structure Of Sars Coronavirus Nsp9 46015387 1 189373 43824 2GDT_A Chain A, Nmr Structure Of The Nonstructural Protein 1 (Nsp1) From The Sars Coronavirus 159164583 1 186629 43337 2GRI_A Chain A, Nmr Structure Of The Sars-Cov Non-Structural Protein Nsp3a 122920339 1 150535 36002 1YSY_A Chain A, Nmr Structure Of The Nonstructural Protein 7 (Nsp7) From The Sars Coronavirus 159163648 1 128747 31583 2BFQ_A Chain A, Macro Domains Are Adp-Ribose Binding Molecules 60594428 1 192117 44348 2DX6_A Chain A, Crystal Structure Of Conserved Hypothetical Protein, Ttha0132 From Thermus Thermophilus Hb8 134104158 1 128747 31583 2BFQ_A Chain A, Macro Domains Are Adp-Ribose Binding Molecules 60594428 2 161978 38253 2FE8_A Chain A, Sars Coronavirus Papain-Like Protease: Structure Of A Viral Deubiquitinating Enzyme 93279494 2 189373 43824 2GDT_A Chain A, Nmr Structure Of The Nonstructural Protein 1 (Nsp1) From The Sars Coronavirus 159164583 2

The "Protein Families" text link opens a cutomizable view of the conserved domains found on the protein chain. This is the results page for a CD-Search of the protein chain against the Conserved Domain Database. The domain families are determined through the identification of blocks of amino acid residues that have been conserved across a broad range of taxonomic nodes and therefore represent recurring units of molecular evolution. The CDD help document provides more details about domains as well as specific hits, superfamilies, and multi-domains.