Chromosome 1

GBA. In Gaucher disease, the defective enzyme is unable to metabolize glucocerebrosides which accumulate in characteristic, distended phagocytic cells IMAGE CREDIT: E. Beutler, Scripps Research Institute, La Jolla, CA, USA AD4. Brain scans of a healthy elderly person and a patient with Alzheimer's disease IMAGE CREDIT: Keith Johnson, Brigham and Women's Hospital, Boston, MA, USA