| Nef | Co-localizes with | Ras-related protein Rab-11A  |
| Induces release of | Fc fragment of IgE, low affinity II, receptor for (CD23A)  |
| | intercellular adhesion molecule 1 precursor  |
| Inhibits | hemopoietic cell kinase isoform p61HCK  |
| | interleukin 2 precursor  |
| | mitogen-activated protein kinase 1  |
| Interacts with | adaptor-related protein complex 1, mu 1 subunit  |
| | chemokine (C-X-C motif) receptor 4 isoform b  |
| | dedicator of cytokinesis 2  |
| | DnaJ (Hsp40) homolog, subfamily B, member 1  |
| | engulfment and cell motility 1 isoform 1  |
| | inositol 1,4,5-triphosphate receptor, type 1  |
| | lymphocyte-specific protein tyrosine kinase precursor  |
| | ras-related C3 botulinum toxin substrate 1 isoform Rac1  |
| | ras-related C3 botulinum toxin substrate 2  |
| | T-cell receptor zeta chain isoform 1 precursor  |
| Modulates | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase  |
| Requires | adaptor-related protein complex 2, mu 1 subunit isoform a  |
| Upregulates | DnaJ (Hsp40) homolog, subfamily B, member 1  |
| | T-cell receptor zeta chain isoform 1 precursor  |
| activates | adenylate cyclase 2  |
| | adenylate cyclase 3  |
| | adenylate cyclase 4  |
| | adenylate cyclase 5  |
| | adenylate cyclase 6 isoform a  |
| | adenylate cyclase 7  |
| | adenylate cyclase 8  |
| | adenylate cyclase 9  |
| | ADP-ribosylation factor 6  |
| | brain adenylate cyclase 1  |
| | caspase 3 preproprotein  |
| | hemopoietic cell kinase isoform p61HCK  |
| | interferon regulatory factor 3  |
| | jun oncogene  |
| | matrix metalloproteinase 9 preproprotein  |
| | mitogen-activated protein kinase 1  |
| | mitogen-activated protein kinase 14 isoform 1  |
| | mitogen-activated protein kinase 3 isoform 1  |
| | mitogen-activated protein kinase 8 isoform JNK1 alpha2  |
| | nuclear factor kappa-B, subunit 1  |
| | nuclear factor of activated T-cells, cytosolic component 1 isoform A  |
| | p21-activated kinase 1  |
| | p21-activated kinase 2  |
| | ras-related C3 botulinum toxin substrate 1 isoform Rac1  |
| | signal transducer and activator of transcription 1 isoform alpha  |
| | signal transducer and activator of transcription 3 isoform 1  |
| | v-fos FBJ murine osteosarcoma viral oncogene homolog  |
| | v-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1  |
| | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog  |
| associates with | actin, gamma 1 propeptide  |
| | beta actin  |
| | p21-activated kinase 1  |
| | p21-activated kinase 2  |
| binds | adaptor-related protein complex 1 beta 1 subunit isoform a  |
| | adaptor-related protein complex 1 sigma 2 subunit  |
| | adaptor-related protein complex 1, gamma 1 subunit isoform b  |
| | adaptor-related protein complex 1, gamma 2 subunit  |
| | adaptor-related protein complex 1, mu 1 subunit  |
| | adaptor-related protein complex 1, sigma 1 subunit isoform 1  |
| | adaptor-related protein complex 1, sigma 3 subunit  |
| | adaptor-related protein complex 2, beta 1 subunit isoform b  |
| | adaptor-related protein complex 3, delta 1 subunit isoform 2  |
| | ADP-ribosylation factor 1  |
| | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H isoform 1  |
| | calmodulin 1  |
| | CD4 antigen precursor  |
| | CD80 antigen precursor  |
| | CD86 antigen isoform 1  |
| | coatomer protein complex, subunit beta  |
| | embryonic ectoderm development isoform a  |
| | GATA binding protein 1  |
| | GATA binding protein 3 isoform 2  |
| | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1  |
| | guanine nucleotide binding protein, alpha activating polypeptide O  |
| | hemopoietic cell kinase isoform p61HCK  |
| | lymphocyte-specific protein tyrosine kinase precursor  |
| | major histocompatibility complex, class I, A precursor  |
| | major histocompatibility complex, class I, B  |
| | major histocompatibility complex, class I, C precursor  |
| | major histocompatibility complex, class I, E precursor  |
| | major histocompatibility complex, class I, F precursor  |
| | major histocompatibility complex, class I, G precursor  |
| | mitogen-activated protein kinase 1  |
| | mitogen-activated protein kinase kinase kinase 5  |
| | Nef-associated factor 1  |
| | p21-activated kinase 2  |
| | peptidylprolyl isomerase A  |
| | peroxisomal acyl-CoA thioesterase 1 isoform a  |
| | phosphofurin acidic cluster sorting protein 1  |
| | phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 1  |
| | programmed cell death 6 interacting protein  |
| | proteasome beta 4 subunit  |
| | protein-tyrosine kinase fyn isoform a  |
| | proto-oncogene tyrosine-protein kinase SRC  |
| | tumor protein p53  |
| | v-raf-1 murine leukemia viral oncogene homolog 1  |
| | vav 1 oncogene  |
| co-localizes with | adaptor-related protein complex 2, beta 1 subunit isoform b  |
| | adaptor-related protein complex 3, delta 1 subunit isoform 2  |
| | CD28 antigen  |
| | CD8b antigen isoform 1 precursor  |
| | coatomer protein complex, subunit beta  |
| | glial fibrillary acidic protein  |
| | major histocompatibility complex, class I, A precursor  |
| | major histocompatibility complex, class I, B  |
| | p21-activated kinase 2  |
| degrades | CD4 antigen precursor  |
| | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha  |
| downregulates | ATP-binding cassette, sub-family A member 1  |
| | B-cell lymphoma protein 2 alpha isoform  |
| | BCL2-like 1 isoform 1  |
| | CD1A antigen precursor  |
| | CD1D antigen precursor  |
| | CD28 antigen  |
| | CD3D antigen, delta polypeptide isoform A precursor  |
| | CD3E antigen, epsilon polypeptide (TiT3 complex)  |
| | CD3G gamma precursor  |
| | CD4 antigen precursor  |
| | CD69 antigen (p60, early T-cell activation antigen)  |
| | CD8 antigen alpha polypeptide isoform 1 precursor  |
| | CD80 antigen precursor  |
| | CD86 antigen isoform 1  |
| | CD8b antigen isoform 1 precursor  |
| | chemokine (C-C motif) receptor 5  |
| | chemokine (C-X-C motif) receptor 4 isoform b  |
| | cyclin E1 isoform 1  |
| | Fc fragment of IgG, high affinity Ia, receptor (CD64)  |
| | Fc fragment of IgG, low affinity IIa, receptor for (CD32)  |
| | Fc fragment of IgG, low affinity IIb, receptor for (CD32) isoform 1  |
| | hemochromatosis protein isoform 1 precursor  |
| | interferon, gamma  |
| | interleukin 2 precursor  |
| | interleukin 2 receptor, alpha chain precursor  |
| | jun oncogene  |
| | major histocompatibility complex, class I, A precursor  |
| | major histocompatibility complex, class I, B  |
| | major histocompatibility complex, class I, C precursor  |
| | major histocompatibility complex, class I, E precursor  |
| | major histocompatibility complex, class I, F precursor  |
| | major histocompatibility complex, class I, G precursor  |
| | major histocompatibility complex, class II, DR alpha precursor  |
| | mannose receptor C type 1 precursor  |
| | nuclear factor kappa-B, subunit 1  |
| | peroxisome proliferative activated receptor gamma isoform 1  |
| | phosphoinositide-3-kinase, catalytic, alpha polypeptide  |
| | proteasome beta 4 subunit  |
| | protein kinase C, beta isoform 2  |
| | protein kinase C, epsilon  |
| | synaptopodin  |
| | transferrin receptor  |
| | v-fos FBJ murine osteosarcoma viral oncogene homolog  |
| | Wilms tumor 1 isoform A  |
| inactivates | caspase 3 preproprotein  |
| | caspase 8 isoform A precursor  |
| | lymphocyte-specific protein tyrosine kinase precursor  |
| induces cleavage of | poly (ADP-ribose) polymerase family, member 1  |
| induces complex with | Cas-Br-M (murine) ecotropic retroviral transforming sequence  |
| | Rho guanine nucleotide exchange factor 7 isoform a  |
| induces phosphorylation of | BCL2-antagonist of cell death protein  |
| | Cas-Br-M (murine) ecotropic retroviral transforming sequence  |
| | conserved helix-loop-helix ubiquitous kinase  |
| | ELK1 protein  |
| | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta  |
| | neurofibromin 2 isoform 1  |
| | Rac/Cdc42 guanine nucleotide exchange factor 6  |
| induces rearrangement of | actin, gamma 1 propeptide  |
| | beta actin  |
| inhibits | apolipoprotein A-I preproprotein  |
| | CD40 ligand  |
| | cell division cycle 42 isoform 1  |
| | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) isoform beta  |
| | chemokine (C-X-C motif) receptor 4 isoform b  |
| | colony stimulating factor 1 receptor precursor  |
| | endothelin 1  |
| | interleukin 10 precursor  |
| | interleukin 2 precursor  |
| | interleukin 4 isoform 1 precursor  |
| | major histocompatibility complex, class I, A precursor  |
| | major histocompatibility complex, class II, DR alpha precursor  |
| | mitogen-activated protein kinase 1  |
| | mitogen-activated protein kinase kinase kinase 5  |
| | NADPH oxidase 1 isoform long  |
| | nuclear factor kappa-B, subunit 1  |
| | nuclear factor of activated T-cells, cytosolic component 1 isoform A  |
| | tumor necrosis factor alpha  |
| | tumor necrosis factor receptor superfamily, member 6 isoform 1 precursor  |
| | Wiskott-Aldrich syndrome gene-like protein  |
| interacts with | adaptor-related protein complex 1 beta 1 subunit isoform a  |
| | adaptor-related protein complex 1 sigma 2 subunit  |
| | adaptor-related protein complex 1, gamma 2 subunit  |
| | adaptor-related protein complex 1, mu 1 subunit  |
| | adaptor-related protein complex 1, sigma 1 subunit isoform 1  |
| | adaptor-related protein complex 1, sigma 3 subunit  |
| | adaptor-related protein complex 3, mu 1 subunit  |
| | beta actin  |
| | calmodulin 1  |
| | calmodulin 2  |
| | calmodulin 3  |
| | CD4 antigen precursor  |
| | CD80 antigen precursor  |
| | cell division cycle 42 isoform 1  |
| | chemokine (C-X-C motif) receptor 3  |
| | chemokine (C-X-C motif) receptor 4 isoform b  |
| | clathrin heavy chain 1  |
| | cyclin-dependent kinase 9  |
| | DnaJ (Hsp40) homolog, subfamily B, member 1  |
| | hemopoietic cell kinase isoform p61HCK  |
| | integrin alpha L precursor  |
| | integrin alpha M precursor  |
| | intercellular adhesion molecule 1 precursor  |
| | interleukin 2 precursor  |
| | lymphocyte-specific protein tyrosine kinase precursor  |
| | major histocompatibility complex, class II, DR beta 1 precursor  |
| | N-myristoyltransferase 1  |
| | p21-activated kinase 2  |
| | phosphoinositide-3-kinase, catalytic, alpha polypeptide  |
| | protein kinase C, theta  |
| | ras-related C3 botulinum toxin substrate 1 isoform Rac1  |
| | T-cell receptor zeta chain isoform 1 precursor  |
| | tumor protein p53  |
| | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog  |
| modulates | CD4 antigen precursor  |
| | major histocompatibility complex, class I, A precursor  |
| | major histocompatibility complex, class I, B  |
| | |