Pathogenesis and immune response in Brucella infection acquired by the respiratory route

Microbes Infect. 2020 Oct;22(9):407-415. doi: 10.1016/j.micinf.2020.06.001. Epub 2020 Jun 11.

Abstract

Brucella infection is frequently acquired through the respiratory route. The pathogen disseminates systemically from the lungs to infect peripheral organs. In this review we summarize the existing data on the pathogenesis of inhalational Brucella infection, the pulmonary immune response to the pathogen, and potential strategies for inducing protective lung immunity.

Keywords: Brucella; Immune response; Inhalational infection; Pathogenesis; Vaccines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brucella / immunology
  • Brucella / pathogenicity
  • Brucella Vaccine / immunology
  • Brucellosis / immunology*
  • Humans
  • Immunity*
  • Lung / immunology*
  • Vaccination
  • Virulence / immunology

Substances

  • Brucella Vaccine