Age-related differences in the frequency of ketoacidosis at diagnosis of type 1 diabetes in children and adolescents

Diabetes Care. 2010 Jul;33(7):1500-2. doi: 10.2337/dc09-2344. Epub 2010 Apr 22.

Abstract

Objective: We studied the prevalence of diabetic ketoacidosis (DKA) at diagnosis of type 1 diabetes in children in Finland.

Research design and methods: From 2002 to 2005, data on virtually all children <15 years of age diagnosed with type 1 diabetes (n = 1,656) in Finland were collected.

Results: DKA was present in 19.4% of the case subjects, and 4.3% had severe DKA. In children aged 0-4, 5-9, and 10-14 years, DKA was present in 16.5, 14.8, and 26.4%, respectively (P < 0.001). Severe DKA occurred in 3.7, 3.1, and 5.9%, respectively (P = 0.048). DKA was present in 30.1% and severe DKA in 7.8% of children aged <2 years.

Conclusion: The overall frequency of DKA in children is low in Finland at diagnosis of type 1 diabetes. However, both children <2 years of age and adolescents aged 10-14 years are at increased risk of DKA.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age Distribution
  • Body Mass Index
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Diabetes Mellitus, Type 1 / epidemiology*
  • Diabetic Ketoacidosis / diagnosis*
  • Diabetic Ketoacidosis / epidemiology*
  • Female
  • Finland / epidemiology
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Risk Factors
  • Severity of Illness Index*