Monitoring and treatment of anti-D in pregnancy

Vox Sang. 2010 Aug 1;99(2):177-92. doi: 10.1111/j.1423-0410.2010.01322.x. Epub 2010 Mar 17.

Abstract

Prophylactic anti-D is a very safe and effective therapy for the suppression of anti-D immunization and thus prevention of haemolytic disease of the foetus and newborn. However, migration from countries with low health standards and substantial cuts in public health expenses have increased the incidence of anti-D immunization in many "developed" countries. Therefore, this forum focuses on prenatal monitoring standards and treatment strategies in pregnancies with anti-D alloimmunization. The following questions were addressed, and a response was obtained from 12 centres, mainly from Europe.

MeSH terms

  • Blood Group Antigens / immunology*
  • Female
  • Fetal Blood / immunology
  • Fetal Hemoglobin / analysis
  • Humans
  • Isoantibodies / administration & dosage*
  • Isoantibodies / blood
  • Isoantibodies / immunology
  • Pregnancy
  • Pregnancy Complications, Hematologic / blood
  • Pregnancy Complications, Hematologic / immunology
  • Pregnancy Complications, Hematologic / prevention & control
  • Pregnancy Complications, Hematologic / therapy*
  • Rh Isoimmunization / immunology
  • Rh Isoimmunization / prevention & control
  • Rh Isoimmunization / therapy*
  • Rh-Hr Blood-Group System / immunology*
  • Rho(D) Immune Globulin

Substances

  • Blood Group Antigens
  • Isoantibodies
  • RHO(D) antibody
  • Rh-Hr Blood-Group System
  • Rho(D) Immune Globulin
  • Fetal Hemoglobin