Human/Mouse Homology Relationships
Michael F. Seldin, Rowe Program in Genetics,
Departments of Biological Chemistry and Medicine,
University of California, Davis.
See below for full contact information.
Please select the chromosome whose homology map you
would like to view. The entire map
is also available in text form.
Human Chromosomes:
Mouse Chromosomes:
Description
This is the Davis Human/Mouse Homology Map, a table comparing genes
in homologous segments of DNA from human and mouse sources, sorted by
position in each genome. A total of 1793 loci are presented, most of which are
genes. The authors did not include pseudogenes, members of multigene families
where specific homology relationships could not be determined, nor any other
genes for which homology was in doubt. In addition, for 568 of the loci
there are provisional assignments of markers that link the homology map with
that of the
Gene Map of the Human Genome. These links also provide a rough
approximation of the position of markers in the Genethon linkage map.
In constructing this table, the authors first ordered genes so as to best
maintain
order according to both human cytogenetic position and mouse genetic map
position. Within these homologous regions, genes were ordered according to the
mouse genetic mapping data. For approximately half of the genes in this
database, no more detailed information is available; thus, much of this map
should be interpreted as a
reflection of probable, not confirmed, homology relationships. Where more
detailed information was to be found, the authors adjusted the map to
correspond to available human physical mapping data, which they consider to be
definitive. The present rendition contains 201 homology groupings.
The previous edition of this table was originally published as
-
DeBry, R. W. and M. F. Seldin. 1996. Human/mouse homology
relationships. Genomics 33, 337-351.
Most of the human genetic map data in this resource is taken from the
CHLC WWW site,
while some data for hChr14 and hChr22 are from
Cox et al.
(
Genomics 23: 331-7, 1994; and
Cytogenet Cell Genet 69:175-8, 1995) and
Collins et al.
(
Nature 377:367-9, 1995).
More detailed data for human physical mapping were obtained from the numerous
human chromosome committee reports, as well as various electronic data
repositories.
For Mouse chromosome positions, most of the information was
originally compiled in the
Mouse Chromosome Committee Reports
and the Mouse Genome
Database at the Jackson Laboratory.
How to contact the authors
Michael F. Seldin
Rowe Program of Genetics, Departments of Biological Chemistry and Medicine
University of California, Davis
Tupper Hall 4303
Davis, CA 95616
Phone: (916)754-6017
FAX: (916)754-6015
email:
mfseldin@ucdavis.edu
Technical questions to the
NCBI Help Desk.
WWW Credits: Brandon Brylawski