NCBI C Toolkit Cross Reference

C/demo/bbone.prt

  1 Seq-entry ::=
  2     set {
  3       class pub-set ,
  4       descr {
  5         pub {
  6           pub {
  7             medline {
  8               uid 91288538 ,
  9               em
 10                 str "1991 Jul 1" ,
 11               cit {
 12                 title {
 13                   name "A phorbol ester/diacylglycerol-binding protein encoded
 14  by the unc-13 gene of Caenorhabditis elegans." } ,
 15                 authors {
 16                   names
 17                     str {
 18                       "Maruyama IN" ,
 19                       "Brenner S" } } ,
 20                 from
 21                   journal {
 22                     title {
 23                       ml-jta "Proc. Natl. Acad. Sci. U.S.A." } ,
 24                     imp {
 25                       date
 26                         str "1991 Jul 1" ,
 27                       volume "88" ,
 28                       issue "13" ,
 29                       pages "5729-33" } } } ,
 30               abstract "Mutations in the unc-13 gene cause diverse defects in
 31  the nervous system of the nematode Caenorhabditis elegans. Molecular cloning
 32  of the gene and sequencing of the cDNA revealed that the product encodes a
 33  protein, 1734 amino acids in length, with a central domain with sequence
 34  similarity to the regulatory region of protein kinase C. The domain was
 35  expressed in Escherichia coli and shown to bind specifically to a phorbol
 36  ester in the presence of calcium; diacylglycerol inhibited the binding in a
 37  competitive manner. These findings confirm that the unc-13 gene product has
 38  binding sites similar to those of protein kinase C and may be a component of
 39  an alternative transduction pathway of the diacylglycerol signal to a
 40  different effector function in the nervous system." ,
 41               mesh {
 42                 {
 43                   term "Amino Acid Sequence" } ,
 44                 {
 45                   term "Animal" } ,
 46                 {
 47                   term "Base Sequence" } ,
 48                 {
 49                   term "Caenorhabditis" } ,
 50                 {
 51                   term "Chromosome Mapping" } ,
 52                 {
 53                   term "DNA" } ,
 54                 {
 55                   term "Genes, Structural" } ,
 56                 {
 57                   term "Molecular Sequence Data" } ,
 58                 {
 59                   term "Phorbol 12,13-Dibutyrate" } ,
 60                 {
 61                   term "Protein Kinase C" } ,
 62                 {
 63                   term "Receptors, Drug" } ,
 64                 {
 65                   term "Recombinant Proteins" } ,
 66                 {
 67                   term "Restriction Mapping" } } ,
 68               substance {
 69                 {
 70                   type ec ,
 71                   cit "2.7.1.-" ,
 72                   name "Protein Kinase C" } ,
 73                 {
 74                   type cas ,
 75                   cit "37558-16-0" ,
 76                   name "Phorbol 12,13-Dibutyrate" } ,
 77                 {
 78                   type cas ,
 79                   cit "9007-49-2" ,
 80                   name "DNA" } } ,
 81               xref {
 82                 {
 83                   type genbank ,
 84                   cit "M62830" } } } } } } ,
 85       seq-set {
 86         set {
 87           class nuc-prot ,
 88           descr {
 89             title "[mRNA] unc-13=phorbol ester/diacylglycerol-binding protein
 90  [Caenorhabditis elegans]; and translated products" ,
 91             org {
 92               taxname "Caenorhabditis elegans" } } ,
 93           seq-set {
 94             seq {
 95               id {
 96                 gibbmt 131777 ,
 97                 gibbsq 39237 } ,
 98               descr {
 99                 mol-type mRNA ,
100                 title "[mRNA] unc-13=phorbol ester/diacylglycerol-binding
101  protein [Caenorhabditis elegans]" ,
102                 pub {
103                   pub {
104                     muid 91288538 } ,
105                   name "unc-13" ,
106                   fig "fig 3" ,
107                   num
108                     cont {
109                        } } } ,
110               inst {
111                 repr raw ,
112                 mol rna ,
113                 length 5376 ,
114                 topology linear ,
115                 seq-data
116                   iupacna "GAATTCATTTTTGAAACAAATCGACCTGACGACGGAATGGTACTCGAATTA
117 TGGGCCAAAGGGTTTTATGGGACAAATTAATAGGTGTTCATTATATGCCACTTTCGGAGATTAGATACAGCAATGCAG
118 CAGGTTCGGGTCAATGGCTTCAAATGGATCATGAACTTGAAACAAGAAATGGTCAAACTGTAGGAACACGTGGTCCAA
119 CAGGTCATAACTTGTTGACTGATGTTCGATTTGAGCTTCCTTTTGATGTACAAGGCCACGACGAAGATGTTCAGTCCA
120 GATTGCTCGCGTTGAACGGACTCATCGAACACGATCAGCTGGGCCCCAACAACCATCACAGGGCGCCGTTTAACCATT
121 CGGGTTTGAGTGAAGACAGTGATTATACATCCGACGTGTCCGTTCCAGTCAACCATCATCAATTACATCCAAACAGTT
122 CGGCACATCAATACGAATCACATCTACATCCACATCGAACACGTCAATTGTTACACACTCGTGAAGGCGCAGCGAGTT
123 ATGAGGACGAAGAAGACGCCTATCACGCTAGACATCAACCCGAATCCGACGACTATAACCACCAAGACACCTACGATC
124 AACATTCGTCGTATTATAACGACGAATACGCGCCAAGTGGTAGTAGCAGTCAATATCAACGGCAAGGATATCAAGATC
125 AAGATCAACAACATCAGAATATATACGAGGACACGGTGACTCCGGTTCGAGAATTTGGCGAGTCGGCCGTTCCGCCGG
126 CTGCTTCATCGTCTAGACGTCAATTCGATCAGGTTTACGGGTACGCATCTAGCAGTGAAGAACGATATGACACACCGA
127 TGTCAAGTGGTCGACTGCCAAGAGATGAACCAATTCTTGAGCACAGTGAACCAGAATACGTGTACGATCAGAATGGTT
128 ATCCCGAAGAAGACAACTATGGAATTAATCCAACATATTCGGAAGATCATTTTGAAGGTCAAACAAATGACTATTCTA
129 CGACACATCAAGAACCTAATGATTTTAGGAATGATTATAATTCTAGTTATCAAAGAGAATATTGGAATGAGAGTGAGC
130 CGCTTTCTTATAATAGTAGGCCTCCAAACGGACATATTAGAACAGGTGCAAACACTTGGCGCGAACCATCTACGTCAT
131 CTCGCCCAACATCTTCCCAAGCATGGAATTATCAAGATGACACTCACCAATATGATGAAGTTGATCGTGGATCCCGAG
132 TATCTTTCACAAGAACACCATCAGTAGATAGAACAGATAGACCAAGTGAAAGTGGTGGAGGATTTTATGATGAAATGT
133 CAGAAAGTGGAAGACCAGGGCGTCCAGATTCTCACCATAATTGGAGATATGATTCAATTCAAGAAGAAGATAATGAAA
134 AAGACAACTGGAAACAACATGTGGAAGGCTACGAAGAAGGACAGGAAGAGAAACAAAAGGACAATCAAAAACCTAATG
135 ATCATAGTGCAGCTTCACCTCAAGATCACTATCATCGATCAGATTCAACAGCGCAACAAGATTTCGGAAACAATATCG
136 TTCGTCAGACAATTCAAGAAGAAGAGGAAAAAAGGAATTATCAGGAACTTTGGCATAATGCTTACAAGAGAGTTTGTG
137 CTGATCTCGGAATTAAGAGTACTGTGCTTGACGGGAACGGGAGTTCGGCTGCCAACGCCTTCTACAAATCAATCGATG
138 CAGCTCCAAACATGAATGTGGCCCGAACGAAGACAAGTATTCCACTTGTTTCCGAACTTGTTCTAAAGACGATGGCCA
139 CAAAACGTGCGCAAGCAGGTCTGGCGAATGCGGCAAGAACGACGTTCTCAGATACAGAATTAAAAACTCATGTCTACA
140 AGAAAACTCTACAAGCATTGATCTACCCGATCAGTGCAACAACTCCTCACAACTTCGCAACTACAACATTCCAAACAC
141 CCACGTTTTGTTACGAATGCGAAGGATTATTGTGGGGATTGGCTAGACAAGGATTGCGATGTACTCAGTGTCAAGTGA
142 AAGTTCACGATAAATGTCGTGAATTGCTCAGCGCTGATTGTCTTCAAAGAGCAGCCGAGAAGTCGACGAAACATGGAG
143 AAGCTGATAGAACACAGTCACTTGTCAATGTTATCAGAGATCGAATGAAGATTCAGGAACAGAATAAGCCTGAAGTGT
144 TTCAGATGATTAGAACAGTTTTTGATGTGGATGAGAATATTCAAAAAGAGACTTTGAAAACTGTAAAGGCGTCTATTT
145 TGGAAGGAAGTAGCAAATGGAGTGCAAAGATTACATTGACAGTGCTTTGTGCGCAGGGACTTATTGCCAAGGACAAAA
146 CCGGAAAAAGTGATCCATATGTGACAGCTCAAGTTGGAAAGACCAAACGAAGGACACGAACCATACACCAAGAGCTCA
147 ATCCAGTTTGGAATGAGAAATTTCATTTTGAATGCCACAACTCCACGGACAGAATTAAAGTTCGAGTTTGGGACGAGG
148 ATAATGATTTGAAATCCAAGTTAAGGCAAAAATTGACTCGTGAATCTGATGATTTCTTGGGACAAACAGTAATTGAAG
149 TTCGAACTTTATCTGGTGAAATGGATGTCTGGTATAATCTTGAAAAGAGAACTGATAAATCTGCTGTATCCGGAGCAA
150 TTCGATTGCATATCAATGTTGAAATCAAGGGAGAAGAGAAACTTGCACCGTATCATGTTCAGTATACATGTCTTCATG
151 AACATCTTTTTGCTGCTCATTGTGTAGATGAAGAAGTTAAACTTCCAAAAGTTCGAGGCGAAGATAGTTGGAAAGTTT
152 GCTTCCAGGAAACTGGTCAAGAGATTGCTGAAGAATTTGCGATGCGGTATGGAATTGAAAGTATTTACCAGGCCATGA
153 CTCATTTCGCATGCCTATGTACTAGATACATGTGCGCAGGAGTACCTGCAGTCTTGTCAACACTTTTGGCCAATATAA
154 ATGCGTACTATGCTCATACAACTGCCACGTCAGCAGTCTCTGCTCCTGATAGATTTGCTGCATCCAACTTCGGAAAAG
155 AACGATTTGTGAAACTTCTTGATCAACTTCACAACAGTTTGAGAATTGACTTGTCAGCATATAGGAATCATTTTCCCT
156 CTTCGTCGCCTGCCAAACTTCAAGATCTTAAATCAACCGTTGATCTTCTTACTTCAATTACATTCTTTCGCATGAAAG
157 TTCTCGAGTTGGCGAGCCCACCGCGAGCATCAACAGTTGTTCGCGAATGCGCAAAAGCCTGCATGCAGCAGACCTATC
158 AACTGATGTTTGAATCATGCGCTGAACAATTCCCAATTTTGGACACTTCAGTTCAATTCTGGTATGAATTCATCGACT
159 ATATAATGCGAGTAATTGAAGAAGATCAAAAAAACTATACACCAGCATTGAATCAATTCCCTCAAGAACTGAATGTTG
160 GGAATTTATCCGCTGAAACACTTTGGAGTATGTACAAGAATGATTTGAAAATGGCATTAGAAGAACATGCACAAAAGA
161 AACGATGCAAGACGCCTGAATATATGAATTTATATTTCAAGGTTAAAGGTTTCTATTTCAAATATGTCGCTGATCTTT
162 CAACATACAAATCATCAATTCCCGAGTTTCCTGCATGGTTTATTCCATTCGTCATGGATTGGCTCAATGAAAATGACG
163 AACATTCGATGGATATTCTCAGAAATGCATACAACTGTAGACAAGCTGACACTTCCCACAAACATCAGAACACACAAA
164 TTCTCGAACATGTTGTTGATGTGTTCACCCAACTAAACGCTGCATTGAAGCTCCTCAAACAAATGGACTGTCCAAATC
165 CAGAAGTTGCTGCTGATATGATGAAGAGATTCAGTAAAACATTGAATAAAGTTCTTCTTGCATACGCTGATATGGTTC
166 AAAAAGATTTTCCGAAATTTGCACATGACGAGAAGCTTGCGTGTATTCTAATGAACAATGTTCAGCAATTACGTGTGC
167 AACTCGAAAAGATCTACGAAACAATGGGCGGAGCAGAACTTGACGAACATATTGGACAAGTGCTTACAGTCCTTCAAA
168 AGAAGTTGAATTCTGTTCTAGACAGACTTTCAGCTGAATTTGTGACCACTTTGGAACCCCATATTCATGAACAAACAA
169 TCAAATTGGGTATGCTCCTCGTTAAAATAAAGGGTCCACAACTTCAAAAGACACAAGTTCAACCGGAAGCCGATGCAG
170 TTCTAGAACCGTTGATGGATCTTCTTGAAGGATCATTGAGAAGATACGCGGATCAGTGTGAGAAAACGGTTCTGAAGT
171 ATATTCTCAAAGAACTTTGGAAAATAACAATTGTTAATATGGAAAAGAGAGTTGTTCTACCACCATTATCAGATAAGG
172 CTCTATTGAAACAACTGCCGAATGCCAAAATTGGAGATGTTACGAAGTTAATGTCAACAAACAATCAAAGTATAAAGG
173 GAATGAATTCCGTTAAAGATATGATGGATATGGCAAGAGAATCTGAAAAATCTCTAACACCCAGACAATGTACAGTTC
174 TTGATTGTGCACTTGACGCCATTAAAGACAGTTTCCATGCATCCGGAAAAGGACTTAAGAAATCATTCTTTGAGAAAT
175 CACCTGAACTCCAATCTCTCAAATATGCACTCAGTTTATATACACAGACTACTGAGCAACTCATCAAAACGTTTATTA
176 CAAGCCAGCGACAGCAAGATCTCCCAAGTCAAGAGCAACCAGTTGGAGAAGTTAGTGTTCAAGTTGACTTATTCAGTC
177 ATCCAGGCACTGGGGAACAGAAGGCTACCGTTAAAATCCTTGCCGCAAACGATCTTCGATGGCAAACCTCGTCAGCTT
178 TCAAACCATTTGTTGAAGTGCATCTTGTCGGACCACATCTTTCAGACAAAAAGAGAAAATGGTCGACAAAGACCAAAG
179 CAGGCAACTGGGCTCCAAAATTCAACGAAACTTTTCATTTCTTCCTTGGAAATGAAGGAGAACCTGAACATTACGAGC
180 TTATGTTTCAAGTCAAGGATTACTGTTTTGCACGAGATGATCGAGTTGTTGGAGTTGGAGTTCTGCAGTTATCATCTG
181 TCGTTGATCAAGCGGGATCCTGCGCCATGTGGGTTCAACTTGGAACTCGACTGCATATCGACGAGACTGGGCTCATTT
182 TGCTCAGGATTCTTTCACAGCGTCAAACTGATGAGGTGGCAAAGGACTTTGTACGCCTAAAAACGGAATGCCGATACG
183 AGACAGAAACAGTAATGGCTGCATCAGCATCAAGTCAAAACATCAATCGAACATAGTGATTCAAGTGCCTTTTTTTGT
184 TGGATTCAAAGCAATAGAGTTGTTCTTCATTCGATCAATTTTCATCTCCTCTACGAATACCTGTACATTTTGTCGTTT
185 TTTTTTTCTTTCCTCGAATTC" } ,
186               annot {
187                 {
188                   data
189                     ftable {
190                       {
191                         id
192                           gibb 131780 ,
193                         data
194                           gene {
195                             locus "unc-13" ,
196                             desc "phorbol ester/diacylglycerol-binding protein" } ,
197                         location
198                           packed-int {
199                             {
200                               from 0 ,
201                               to 5375 ,
202                               strand plus ,
203                               id
204                                 gibbsq 39237 } } } } } } } ,
205             seq {
206               id {
207                 gibbmt 131799 ,
208                 gibbsq 39239 } ,
209               descr {
210                 mol-type peptide ,
211                                 method both ,
212                 title "[Peptide] phorbol ester/diacylglycerol-binding protein
213  [Caenorhabditis elegans]" ,
214                 pub {
215                   pub {
216                     muid 91288538 } ,
217                   name "unc-13" ,
218                   fig "fig 3" ,
219                   num
220                     cont {
221                        } } } ,
222               inst {
223                 repr raw ,
224                 mol aa ,
225                 length 1734 ,
226                 topology linear ,
227                 seq-data
228                   iupacaa "MGQRVLWDKLIGVHYMPLSEIRYSNAAGSGQWLQMDHELETRNGQTVGTRG
229 PTGHNLLTDVRFELPFDVQGHDEDVQSRLLALNGLIEHDQLGPNNHHRAPFNHSGLSEDSDYTSDVSVPVNHHQLHPN
230 SSAHQYESHLHPHRTRQLLHTREGAASYEDEEDAYHARHQPESDDYNHQDTYDQHSSYYNDEYAPSGSSSQYQRQGYQ
231 DQDQQHQNIYEDTVTPVREFGESAVPPAASSSRRQFDQVYGYASSSEERYDTPMSSGRLPRDEPILEHSEPEYVYDQN
232 GYPEEDNYGINPTYSEDHFEGQTNDYSTTHQEPNDFRNDYNSSYQREYWNESEPLSYNSRPPNGHIRTGANTWREPST
233 SSRPTSSQAWNYQDDTHQYDEVDRGSRVSFTRTPSVDRTDRPSESGGGFYDEMSESGRPGRPDSHHNWRYDSIQEEDN
234 EKDNWKQHVEGYEEGQEEKQKDNQKPNDHSAASPQDHYHRSDSTAQQDFGNNIVRQTIQEEEEKRNYQELWHNAYKRV
235 CADLGIKSTVLDGNGSSAANAFYKSIDAAPNMNVARTKTSIPLVSELVLKTMATKRAQAGLANAARTTFSDTELKTHV
236 YKKTLQALIYPISATTPHNFATTTFQTPTFCYECEGLLWGLARQGLRCTQCQVKVHDKCRELLSADCLQRAAEKSTKH
237 GEADRTQSLVNVIRDRMKIQEQNKPEVFQMIRTVFDVDENIQKETLKTVKASILEGSSKWSAKITLTVLCAQGLIAKD
238 KTGKSDPYVTAQVGKTKRRTRTIHQELNPVWNEKFHFECHNSTDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTVI
239 EVRTLSGEMDVWYNLEKRTDKSAVSGAIRLHINVEIKGEEKLAPYHVQYTCLHEHLFAAHCVDEEVKLPKVRGEDSWK
240 VCFQETGQEIAEEFAMRYGIESIYQAMTHFACLCTRYMCAGVPAVLSTLLANINAYYAHTTATSAVSAPDRFAASNFG
241 KERFVKLLDQLHNSLRIDLSAYRNHFPSSSPAKLQDLKSTVDLLTSITFFRMKVLELASPPRASTVVRECAKACMQQT
242 YQLMFESCAEQFPILDTSVQFWYEFIDYIMRVIEEDQKNYTPALNQFPQELNVGNLSAETLWSMYKNDLKMALEEHAQ
243 KKRCKTPEYMNLYFKVKGFYFKYVADLSTYKSSIPEFPAWFIPFVMDWLNENDEHSMDILRNAYNCRQADTSHKHQNT
244 QILEHVVDVFTQLNAALKLLKQMDCPNPEVAADMMKRFSKTLNKVLLAYADMVQKDFPKFAHDEKLACILMNNVQQLR
245 VQLEKIYETMGGAELDEHIGQVLTVLQKKLNSVLDRLSAEFVTTLEPHIHEQTIKLGMLLVKIKGPQLQKTQVQPEAD
246 AVLEPLMDLLEGSLRRYADQCEKTVLKYILKELWKITIVNMEKRVVLPPLSDKALLKQLPNAKIGDVTKLMSTNNQSI
247 KGMNSVKDMMDMARESEKSLTPRQCTVLDCALDAIKDSFHASGKGLKKSFFEKSPELQSLKYALSLYTQTTEQLIKTF
248 ITSQRQQDLPSQEQPVGEVSVQVDLFSHPGTGEQKATVKILAANDLRWQTSSAFKPFVEVHLVGPHLSDKKRKWSTKT
249 KAGNWAPKFNETFHFFLGNEGEPEHYELMFQVKDYCFARDDRVVGVGVLQLSSVVDQAGSCAMWVQLGTRLHIDETGL
250 ILLRILSQRQTDEVAKDFVRLKTECRYETETVMAASASSQNINRT" } ,
251               annot {
252                 {
253                   data
254                     ftable {
255                       {
256                         id
257                           gibb 131801 ,
258                         data
259                           prot {
260                             desc "phorbol ester/diacylglycerol-binding protein" } ,
261                         location
262                           packed-int {
263                             {
264                               from 0 ,
265                               to 1733 ,
266                               strand plus ,
267                               id
268                                 gibbsq 39239 } } } } } } } } ,
269           annot {
270             {
271               data
272                 ftable {
273                   {
274                     id
275                       gibb 131779 ,
276                     data
277                       cdregion {
278                         frame one ,
279                         code {
280                           id 1 } } ,
281                     product
282                       whole
283                         gibbsq 39239 ,
284                     location
285                       packed-int {
286                         {
287                           from 50 ,
288                           to 5251 ,
289                           strand plus ,
290                           id
291                             gibbsq 39237 } } } } } } } } }
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