src/algo/blast/core/matrix_freq_ratios.c

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00001 #ifndef SKIP_DOXYGEN_PROCESSING
00002 static char const rcsid[] =
00003     "$Id: matrix_freq_ratios.c 99676 2007-03-05 20:41:55Z kazimird $";
00004 #endif /* SKIP_DOXYGEN_PROCESSING */
00005 /* ===========================================================================
00006  *
00007  *                            PUBLIC DOMAIN NOTICE
00008  *               National Center for Biotechnology Information
00009  *
00010  *  This software/database is a "United States Government Work" under the
00011  *  terms of the United States Copyright Act.  It was written as part of
00012  *  the author's official duties as a United States Government employee and
00013  *  thus cannot be copyrighted.  This software/database is freely available
00014  *  to the public for use. The National Library of Medicine and the U.S.
00015  *  Government have not placed any restriction on its use or reproduction.
00016  *
00017  *  Although all reasonable efforts have been taken to ensure the accuracy
00018  *  and reliability of the software and data, the NLM and the U.S.
00019  *  Government do not and cannot warrant the performance or results that
00020  *  may be obtained by using this software or data. The NLM and the U.S.
00021  *  Government disclaim all warranties, express or implied, including
00022  *  warranties of performance, merchantability or fitness for any particular
00023  *  purpose.
00024  *
00025  *  Please cite the author in any work or product based on this material.
00026  *
00027  * ===========================================================================
00028  *
00029  * Author:  Christiam Camacho
00030  *
00031  */
00032 
00033 /** @file matrix_freq_ratios.c
00034  *  Definitions for various scoring matrices' frequency ratios.
00035  */
00036     
00037 #include "matrix_freq_ratios.h"
00038 #include "blast_psi_priv.h"
00039 
00040 
00041 /** Underlying frequency ratios for BLOSUM45 */
00042 static const double BLOSUM45_FREQRATIOS[BLASTAA_SIZE][BLASTAA_SIZE] =
00043 {{0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00044   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00045   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00046   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00047   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00048   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00049   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00},
00050  {0.00000000e+00, 2.95043377e+00, 7.34701741e-01, 8.00397827e-01,
00051   6.88936672e-01, 8.25164920e-01, 5.87357723e-01, 1.08031132e+00,
00052   6.54086288e-01, 7.46806187e-01, 7.86209397e-01, 7.12370041e-01,
00053   8.21348665e-01, 7.89043130e-01, 7.08569419e-01, 8.66678731e-01,
00054   6.99695540e-01, 1.30031418e+00, 1.00058530e+00, 1.00992663e+00,
00055   5.65442334e-01, 7.50000000e-01, 6.38727873e-01, 8.41025176e-01,
00056   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 7.26064996e-01},
00057  {0.00000000e+00, 7.34701741e-01, 3.25946658e+00, 6.00232275e-01,
00058   3.59386786e+00, 1.30000108e+00, 4.95670856e-01, 8.85913772e-01,
00059   1.08769141e+00, 4.96979579e-01, 1.02264352e+00, 4.72210752e-01,
00060   5.80058073e-01, 2.86239890e+00, 6.85801186e-01, 9.91862879e-01,
00061   8.29088221e-01, 1.05297301e+00, 9.85207016e-01, 5.20111147e-01,
00062   3.80841719e-01, 7.50000000e-01, 6.27051284e-01, 1.18227759e+00,
00063   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 4.82061098e-01},
00064  {0.00000000e+00, 8.00397827e-01, 6.00232275e-01, 1.70900872e+01,
00065   5.32858023e-01, 5.45353890e-01, 6.01657157e-01, 5.56827599e-01,
00066   4.90637659e-01, 5.42801532e-01, 5.46735291e-01, 6.72663401e-01,
00067   6.03730225e-01, 6.80232381e-01, 4.11520916e-01, 4.86216592e-01,
00068   4.71814444e-01, 7.96941950e-01, 8.21766666e-01, 7.14771712e-01,
00069   3.33596922e-01, 7.50000000e-01, 4.88896599e-01, 5.22760621e-01,
00070   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 6.21018471e-01},
00071  {0.00000000e+00, 6.88936672e-01, 3.59386786e+00, 5.32858023e-01,
00072   5.35580571e+00, 1.64256912e+00, 4.31018420e-01, 7.40433725e-01,
00073   9.76205497e-01, 4.40334375e-01, 9.41681214e-01, 4.62523949e-01,
00074   4.94422549e-01, 1.50174498e+00, 7.24041930e-01, 9.57667486e-01,
00075   7.71179788e-01, 9.29413105e-01, 8.76125496e-01, 4.93585385e-01,
00076   3.73386452e-01, 7.50000000e-01, 6.44927232e-01, 1.38090402e+00,
00077   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 4.53699350e-01},
00078  {0.00000000e+00, 8.25164920e-01, 1.30000108e+00, 5.45353890e-01,
00079   1.64256912e+00, 3.87327599e+00, 4.97795679e-01, 5.76408577e-01,
00080   9.61718230e-01, 4.85270933e-01, 1.27686825e+00, 5.70784073e-01,
00081   6.14865688e-01, 8.93236200e-01, 9.10746443e-01, 1.53097375e+00,
00082   1.01074883e+00, 9.12113764e-01, 8.32873235e-01, 5.55160304e-01,
00083   5.19337483e-01, 7.50000000e-01, 6.16552718e-01, 2.97840479e+00,
00084   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.36776244e-01},
00085  {0.00000000e+00, 5.87357723e-01, 4.95670856e-01, 6.01657157e-01,
00086   4.31018420e-01, 4.97795679e-01, 5.74817622e+00, 4.80346092e-01,
00087   6.79103477e-01, 1.06375667e+00, 5.29188869e-01, 1.30295859e+00,
00088   1.06255416e+00, 5.72439082e-01, 4.51176385e-01, 4.43558969e-01,
00089   5.89537777e-01, 6.09495403e-01, 7.16103747e-01, 9.52475503e-01,
00090   1.35493791e+00, 7.50000000e-01, 2.18456832e+00, 4.77074668e-01,
00091   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 1.20783008e+00},
00092  {0.00000000e+00, 1.08031132e+00, 8.85913772e-01, 5.56827599e-01,
00093   7.40433725e-01, 5.76408577e-01, 4.80346092e-01, 5.07068525e+00,
00094   6.62087167e-01, 4.16341047e-01, 6.77879412e-01, 4.50091586e-01,
00095   5.84692214e-01, 1.05865660e+00, 7.02165561e-01, 6.87007231e-01,
00096   5.70228460e-01, 1.05800656e+00, 6.92819008e-01, 4.79214700e-01,
00097   5.91296285e-01, 7.50000000e-01, 5.49197180e-01, 6.18662539e-01,
00098   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 4.36669292e-01},
00099  {0.00000000e+00, 6.54086288e-01, 1.08769141e+00, 4.90637659e-01,
00100   9.76205497e-01, 9.61718230e-01, 6.79103477e-01, 6.62087167e-01,
00101   9.51252809e+00, 4.53313059e-01, 8.90272071e-01, 6.69868446e-01,
00102   9.18088604e-01, 1.22006964e+00, 6.61223470e-01, 1.15049417e+00,
00103   9.73045615e-01, 8.54331847e-01, 7.06245757e-01, 4.56693295e-01,
00104   4.51816356e-01, 7.50000000e-01, 1.47204221e+00, 1.03383965e+00,
00105   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.83746261e-01},
00106  {0.00000000e+00, 7.46806187e-01, 4.96979579e-01, 5.42801532e-01,
00107   4.40334375e-01, 4.85270933e-01, 1.06375667e+00, 4.16341047e-01,
00108   4.53313059e-01, 3.23256769e+00, 5.32316397e-01, 1.59618413e+00,
00109   1.45527106e+00, 5.64240025e-01, 6.09639867e-01, 5.77938325e-01,
00110   4.88387978e-01, 6.18410187e-01, 8.47505386e-01, 2.17596400e+00,
00111   5.64907506e-01, 7.50000000e-01, 9.06458192e-01, 5.20674297e-01,
00112   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 2.24695958e+00},
00113  {0.00000000e+00, 7.86209397e-01, 1.02264352e+00, 5.46735291e-01,
00114   9.41681214e-01, 1.27686825e+00, 5.29188869e-01, 6.77879412e-01,
00115   8.90272071e-01, 5.32316397e-01, 3.32707189e+00, 5.53563636e-01,
00116   7.37955763e-01, 1.11877807e+00, 7.81202774e-01, 1.33004839e+00,
00117   1.94261316e+00, 8.89937552e-01, 8.84562104e-01, 5.91651856e-01,
00118   5.61572955e-01, 7.50000000e-01, 7.37107274e-01, 1.29718560e+00,
00119   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.45113795e-01},
00120  {0.00000000e+00, 7.12370041e-01, 4.72210752e-01, 6.72663401e-01,
00121   4.62523949e-01, 5.70784073e-01, 1.30295859e+00, 4.50091586e-01,
00122   6.69868446e-01, 1.59618413e+00, 5.53563636e-01, 2.99708655e+00,
00123   1.73144954e+00, 4.83712850e-01, 4.77913692e-01, 6.42028706e-01,
00124   6.01135200e-01, 5.55659969e-01, 7.80723755e-01, 1.33363845e+00,
00125   6.70858407e-01, 7.50000000e-01, 9.65090110e-01, 5.98002922e-01,
00126   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 2.43995990e+00},
00127  {0.00000000e+00, 8.21348665e-01, 5.80058073e-01, 6.03730225e-01,
00128   4.94422549e-01, 6.14865688e-01, 1.06255416e+00, 5.84692214e-01,
00129   9.18088604e-01, 1.45527106e+00, 7.37955763e-01, 1.73144954e+00,
00130   4.11411354e+00, 6.81741591e-01, 6.43682874e-01, 9.40467390e-01,
00131   7.75906233e-01, 6.60370266e-01, 8.60449567e-01, 1.23582796e+00,
00132   6.34345311e-01, 7.50000000e-01, 1.02316322e+00, 7.39261071e-01,
00133   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 1.62161577e+00},
00134  {0.00000000e+00, 7.89043130e-01, 2.86239890e+00, 6.80232381e-01,
00135   1.50174498e+00, 8.93236200e-01, 5.72439082e-01, 1.05865660e+00,
00136   1.22006964e+00, 5.64240025e-01, 1.11877807e+00, 4.83712850e-01,
00137   6.81741591e-01, 4.47803773e+00, 6.40394172e-01, 1.03246645e+00,
00138   8.97848625e-01, 1.19968790e+00, 1.11473028e+00, 5.51607804e-01,
00139   3.89694095e-01, 7.50000000e-01, 6.05825405e-01, 9.46428796e-01,
00140   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.15737804e-01},
00141  {0.00000000e+00, 7.08569419e-01, 6.85801186e-01, 4.11520916e-01,
00142   7.24041930e-01, 9.10746443e-01, 4.51176385e-01, 7.02165561e-01,
00143   6.61223470e-01, 6.09639867e-01, 7.81202774e-01, 4.77913692e-01,
00144   6.43682874e-01, 6.40394172e-01, 8.81911509e+00, 7.15515810e-01,
00145   5.81631739e-01, 7.49733904e-01, 8.56242933e-01, 5.40037335e-01,
00146   5.25005050e-01, 7.50000000e-01, 4.78832406e-01, 8.36159027e-01,
00147   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.30300041e-01},
00148  {0.00000000e+00, 8.66678731e-01, 9.91862879e-01, 4.86216592e-01,
00149   9.57667486e-01, 1.53097375e+00, 4.43558969e-01, 6.87007231e-01,
00150   1.15049417e+00, 5.77938325e-01, 1.33004839e+00, 6.42028706e-01,
00151   9.40467390e-01, 1.03246645e+00, 7.15515810e-01, 4.40728842e+00,
00152   1.32912854e+00, 1.09183956e+00, 7.80601862e-01, 5.47266398e-01,
00153   6.45177884e-01, 7.50000000e-01, 8.29182983e-01, 2.62986317e+00,
00154   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 6.16540522e-01},
00155  {0.00000000e+00, 6.99695540e-01, 8.29088221e-01, 4.71814444e-01,
00156   7.71179788e-01, 1.01074883e+00, 5.89537777e-01, 5.70228460e-01,
00157   9.73045615e-01, 4.88387978e-01, 1.94261316e+00, 6.01135200e-01,
00158   7.75906233e-01, 8.97848625e-01, 5.81631739e-01, 1.32912854e+00,
00159   4.74702063e+00, 7.99048209e-01, 7.15164318e-01, 5.77699501e-01,
00160   5.80165842e-01, 7.50000000e-01, 8.07446927e-01, 1.13238507e+00,
00161   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.56296615e-01},
00162  {0.00000000e+00, 1.30031418e+00, 1.05297301e+00, 7.96941950e-01,
00163   9.29413105e-01, 9.12113764e-01, 6.09495403e-01, 1.05800656e+00,
00164   8.54331847e-01, 6.18410187e-01, 8.89937552e-01, 5.55659969e-01,
00165   6.60370266e-01, 1.19968790e+00, 7.49733904e-01, 1.09183956e+00,
00166   7.99048209e-01, 2.78188630e+00, 1.47248598e+00, 7.27836330e-01,
00167   4.28363793e-01, 7.50000000e-01, 7.05878947e-01, 9.80777594e-01,
00168   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.80615182e-01},
00169  {0.00000000e+00, 1.00058530e+00, 9.85207016e-01, 8.21766666e-01,
00170   8.76125496e-01, 8.32873235e-01, 7.16103747e-01, 6.92819008e-01,
00171   7.06245757e-01, 8.47505386e-01, 8.84562104e-01, 7.80723755e-01,
00172   8.60449567e-01, 1.11473028e+00, 8.56242933e-01, 7.80601862e-01,
00173   7.15164318e-01, 1.47248598e+00, 3.13871529e+00, 1.04019697e+00,
00174   4.54128072e-01, 7.50000000e-01, 7.43457494e-01, 8.12903077e-01,
00175   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 8.07282226e-01},
00176  {0.00000000e+00, 1.00992663e+00, 5.20111147e-01, 7.14771712e-01,
00177   4.93585385e-01, 5.55160304e-01, 9.52475503e-01, 4.79214700e-01,
00178   4.56693295e-01, 2.17596400e+00, 5.91651856e-01, 1.33363845e+00,
00179   1.23582796e+00, 5.51607804e-01, 5.40037335e-01, 5.47266398e-01,
00180   5.77699501e-01, 7.27836330e-01, 1.04019697e+00, 2.87075890e+00,
00181   4.73320057e-01, 7.50000000e-01, 8.09252575e-01, 5.52144455e-01,
00182   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 1.66862396e+00},
00183  {0.00000000e+00, 5.65442334e-01, 3.80841719e-01, 3.33596922e-01,
00184   3.73386452e-01, 5.19337483e-01, 1.35493791e+00, 5.91296285e-01,
00185   4.51816356e-01, 5.64907506e-01, 5.61572955e-01, 6.70858407e-01,
00186   6.34345311e-01, 3.89694095e-01, 5.25005050e-01, 6.45177884e-01,
00187   5.80165842e-01, 4.28363793e-01, 4.54128072e-01, 4.73320057e-01,
00188   2.97023509e+01, 7.50000000e-01, 1.80096028e+00, 5.67414520e-01,
00189   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 6.28722660e-01},
00190  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00191   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00192   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00193   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00194   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00195   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00196   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 7.50000000e-01},
00197  {0.00000000e+00, 6.38727873e-01, 6.27051284e-01, 4.88896599e-01,
00198   6.44927232e-01, 6.16552718e-01, 2.18456832e+00, 5.49197180e-01,
00199   1.47204221e+00, 9.06458192e-01, 7.37107274e-01, 9.65090110e-01,
00200   1.02316322e+00, 6.05825405e-01, 4.78832406e-01, 8.29182983e-01,
00201   8.07446927e-01, 7.05878947e-01, 7.43457494e-01, 8.09252575e-01,
00202   1.80096028e+00, 7.50000000e-01, 5.75351902e+00, 6.97787623e-01,
00203   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 9.41772708e-01},
00204  {0.00000000e+00, 8.41025176e-01, 1.18227759e+00, 5.22760621e-01,
00205   1.38090402e+00, 2.97840479e+00, 4.77074668e-01, 6.18662539e-01,
00206   1.03383965e+00, 5.20674297e-01, 1.29718560e+00, 5.98002922e-01,
00207   7.39261071e-01, 9.46428796e-01, 8.36159027e-01, 2.62986317e+00,
00208   1.13238507e+00, 9.80777594e-01, 8.12903077e-01, 5.52144455e-01,
00209   5.67414520e-01, 7.50000000e-01, 6.97787623e-01, 2.84524527e+00,
00210   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.67250003e-01},
00211  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00212   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00213   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00214   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00215   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00216   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00217   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 7.50000000e-01},
00218  {0.00000000e+00, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00219   2.90000000e-01, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00220   2.90000000e-01, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00221   2.90000000e-01, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00222   2.90000000e-01, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00223   2.90000000e-01, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00224   2.90000000e-01, 1.33300000e+00, 2.90000000e-01, 2.90000000e-01},
00225  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00226   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00227   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00228   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00229   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00230   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00231   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 7.50000000e-01},
00232  {0.00000000e+00, 7.26064996e-01, 4.82061098e-01, 6.21018471e-01,
00233   4.53699350e-01, 5.36776244e-01, 1.20783008e+00, 4.36669292e-01,
00234   5.83746261e-01, 2.24695958e+00, 5.45113795e-01, 2.43995990e+00,
00235   1.62161577e+00, 5.15737804e-01, 5.30300041e-01, 6.16540522e-01,
00236   5.56296615e-01, 5.80615182e-01, 8.07282226e-01, 1.66862396e+00,
00237   6.28722660e-01, 7.50000000e-01, 9.41772708e-01, 5.67250003e-01,
00238   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 2.36320536e+00}};
00239 
00240 
00241 /** Underlying frequency ratios for BLOSUM50 */
00242 static const double BLOSUM50_FREQRATIOS[BLASTAA_SIZE][BLASTAA_SIZE] =
00243 {{0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00244   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00245   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00246   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00247   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00248   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00249   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00},
00250  {0.00000000e+00, 3.27354473e+00, 6.87168642e-01, 8.87624875e-01,
00251   6.59704230e-01, 7.97359654e-01, 5.46298170e-01, 1.10130683e+00,
00252   6.41220589e-01, 7.15157692e-01, 7.47622201e-01, 6.56954186e-01,
00253   8.53472686e-01, 7.19514908e-01, 7.14770771e-01, 8.19913708e-01,
00254   6.68351460e-01, 1.36359270e+00, 9.67331593e-01, 9.81625416e-01,
00255   4.63560176e-01, 7.50000000e-01, 5.96400452e-01, 8.05980349e-01,
00256   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 6.80310043e-01},
00257  {0.00000000e+00, 6.87168642e-01, 3.67565906e+00, 5.07294595e-01,
00258   4.02052534e+00, 1.31892999e+00, 3.83849184e-01, 8.47577177e-01,
00259   1.11810068e+00, 4.07212168e-01, 9.68440788e-01, 3.91166888e-01,
00260   5.16058658e-01, 3.26949213e+00, 6.61247189e-01, 9.98204754e-01,
00261   7.59007679e-01, 1.06055276e+00, 9.55438618e-01, 4.46192804e-01,
00262   3.38571955e-01, 7.50000000e-01, 5.55905269e-01, 1.19634119e+00,
00263   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 3.97605526e-01},
00264  {0.00000000e+00, 8.87624875e-01, 5.07294595e-01, 1.82308935e+01,
00265   4.27724382e-01, 4.56030174e-01, 5.64985221e-01, 5.24350848e-01,
00266   5.17412429e-01, 5.87186086e-01, 4.59864212e-01, 6.50074165e-01,
00267   6.80946766e-01, 6.01008569e-01, 4.03060607e-01, 4.81296027e-01,
00268   4.27834290e-01, 8.29850973e-01, 8.17890869e-01, 8.08665030e-01,
00269   3.12131245e-01, 7.50000000e-01, 5.38704705e-01, 4.65687383e-01,
00270   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 6.24838486e-01},
00271  {0.00000000e+00, 6.59704230e-01, 4.02052534e+00, 4.27724382e-01,
00272   6.11147890e+00, 1.65784569e+00, 3.37276799e-01, 7.44468416e-01,
00273   8.83789762e-01, 3.70146565e-01, 8.90348134e-01, 3.72923686e-01,
00274   4.35009775e-01, 1.55790069e+00, 7.09628659e-01, 9.66997497e-01,
00275   6.78533894e-01, 9.21480865e-01, 8.25179634e-01, 4.31712984e-01,
00276   3.07050170e-01, 7.50000000e-01, 5.04473723e-01, 1.39378711e+00,
00277   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 3.71809285e-01},
00278  {0.00000000e+00, 7.97359654e-01, 1.31892999e+00, 4.56030174e-01,
00279   1.65784569e+00, 4.43735647e+00, 4.56055858e-01, 5.39909105e-01,
00280   9.11487897e-01, 4.15558851e-01, 1.33108575e+00, 4.78428941e-01,
00281   6.05096970e-01, 9.19771370e-01, 8.38805682e-01, 1.67134451e+00,
00282   9.76357610e-01, 8.82100970e-01, 8.19031320e-01, 4.79075838e-01,
00283   5.48039829e-01, 7.50000000e-01, 6.51686488e-01, 3.38012103e+00,
00284   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 4.53200481e-01},
00285  {0.00000000e+00, 5.46298170e-01, 3.83849184e-01, 5.64985221e-01,
00286   3.37276799e-01, 4.56055858e-01, 6.63625360e+00, 4.13949535e-01,
00287   7.54714659e-01, 9.89742646e-01, 4.44979578e-01, 1.26171801e+00,
00288   1.05158910e+00, 4.38699901e-01, 3.75736079e-01, 4.16967765e-01,
00289   4.61789222e-01, 5.52981315e-01, 5.70349305e-01, 8.59643167e-01,
00290   1.34807169e+00, 7.50000000e-01, 2.42442622e+00, 4.41115461e-01,
00291   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 1.15257995e+00},
00292  {0.00000000e+00, 1.10130683e+00, 8.47577177e-01, 5.24350848e-01,
00293   7.44468416e-01, 5.39909105e-01, 4.13949535e-01, 5.79218671e+00,
00294   6.01271290e-01, 3.70370366e-01, 6.54870319e-01, 3.76903001e-01,
00295   5.19438610e-01, 9.69013722e-01, 6.20168128e-01, 6.41416113e-01,
00296   5.16985831e-01, 9.99248542e-01, 6.36269018e-01, 4.02720033e-01,
00297   5.04888636e-01, 7.50000000e-01, 4.67274430e-01, 5.78707493e-01,
00298   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 3.74281590e-01},
00299  {0.00000000e+00, 6.41220589e-01, 1.11810068e+00, 5.17412429e-01,
00300   8.83789762e-01, 9.11487897e-01, 7.54714659e-01, 6.01271290e-01,
00301   1.04489376e+01, 4.11545408e-01, 9.45545516e-01, 5.47445792e-01,
00302   7.60124356e-01, 1.39406083e+00, 5.81906417e-01, 1.20911332e+00,
00303   9.81604707e-01, 8.22540644e-01, 6.52641826e-01, 4.13620259e-01,
00304   4.75002356e-01, 7.50000000e-01, 1.57000854e+00, 1.02524740e+00,
00305   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 4.92911793e-01},
00306  {0.00000000e+00, 7.15157692e-01, 4.07212168e-01, 5.87186086e-01,
00307   3.70146565e-01, 4.15558851e-01, 9.89742646e-01, 3.70370366e-01,
00308   4.11545408e-01, 3.41093885e+00, 4.68297844e-01, 1.69677965e+00,
00309   1.43810563e+00, 4.50866254e-01, 5.11210841e-01, 5.02656404e-01,
00310   4.35318230e-01, 5.45643330e-01, 8.60722536e-01, 2.31272269e+00,
00311   5.22495607e-01, 7.50000000e-01, 8.26095669e-01, 4.48849604e-01,
00312   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 2.38463611e+00},
00313  {0.00000000e+00, 7.47622201e-01, 9.68440788e-01, 4.59864212e-01,
00314   8.90348134e-01, 1.33108575e+00, 4.44979578e-01, 6.54870319e-01,
00315   9.45545516e-01, 4.68297844e-01, 3.88090096e+00, 4.79194854e-01,
00316   6.85231759e-01, 1.06041456e+00, 7.63679086e-01, 1.41855717e+00,
00317   2.06468049e+00, 8.92977250e-01, 8.44796364e-01, 5.22802406e-01,
00318   4.61593643e-01, 7.50000000e-01, 6.67754286e-01, 1.36451940e+00,
00319   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 4.74822110e-01},
00320  {0.00000000e+00, 6.56954186e-01, 3.91166888e-01, 6.50074165e-01,
00321   3.72923686e-01, 4.78428941e-01, 1.26171801e+00, 3.76903001e-01,
00322   5.47445792e-01, 1.69677965e+00, 4.79194854e-01, 3.32815910e+00,
00323   1.78991633e+00, 4.12652855e-01, 4.43674459e-01, 5.62937315e-01,
00324   5.54029894e-01, 5.10605044e-01, 7.59171671e-01, 1.32427289e+00,
00325   6.01518374e-01, 7.50000000e-01, 8.58373419e-01, 5.10730048e-01,
00326   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 2.67352044e+00},
00327  {0.00000000e+00, 8.53472686e-01, 5.16058658e-01, 6.80946766e-01,
00328   4.35009775e-01, 6.05096970e-01, 1.05158910e+00, 5.19438610e-01,
00329   7.60124356e-01, 1.43810563e+00, 6.85231759e-01, 1.78991633e+00,
00330   4.81561797e+00, 6.11514139e-01, 5.44813932e-01, 9.59915799e-01,
00331   6.78015272e-01, 6.82291911e-01, 8.82308943e-01, 1.21329921e+00,
00332   7.61522900e-01, 7.50000000e-01, 9.17831903e-01, 7.40717150e-01,
00333   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 1.64874201e+00},
00334  {0.00000000e+00, 7.19514908e-01, 3.26949213e+00, 6.01008569e-01,
00335   1.55790069e+00, 9.19771370e-01, 4.38699901e-01, 9.69013722e-01,
00336   1.39406083e+00, 4.50866254e-01, 1.06041456e+00, 4.12652855e-01,
00337   6.11514139e-01, 5.28532229e+00, 6.04265819e-01, 1.03495916e+00,
00338   8.53785837e-01, 1.22434496e+00, 1.10885139e+00, 4.63246441e-01,
00339   3.75696800e-01, 7.50000000e-01, 6.16478872e-01, 9.63798879e-01,
00340   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 4.27987098e-01},
00341  {0.00000000e+00, 7.14770771e-01, 6.61247189e-01, 4.03060607e-01,
00342   7.09628659e-01, 8.38805682e-01, 3.75736079e-01, 6.20168128e-01,
00343   5.81906417e-01, 5.11210841e-01, 7.63679086e-01, 4.43674459e-01,
00344   5.44813932e-01, 6.04265819e-01, 1.02035160e+01, 7.50499600e-01,
00345   5.18638945e-01, 7.59438841e-01, 7.48565360e-01, 5.24438149e-01,
00346   4.20092966e-01, 7.50000000e-01, 4.68173126e-01, 8.05053001e-01,
00347   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 4.70775405e-01},
00348  {0.00000000e+00, 8.19913708e-01, 9.98204754e-01, 4.81296027e-01,
00349   9.66997497e-01, 1.67134451e+00, 4.16967765e-01, 6.41416113e-01,
00350   1.20911332e+00, 5.02656404e-01, 1.41855717e+00, 5.62937315e-01,
00351   9.59915799e-01, 1.03495916e+00, 7.50499600e-01, 4.69722165e+00,
00352   1.35733364e+00, 1.06872445e+00, 8.10316946e-01, 5.57384267e-01,
00353   7.14705591e-01, 7.50000000e-01, 7.42076535e-01, 2.82790659e+00,
00354   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.38747839e-01},
00355  {0.00000000e+00, 6.68351460e-01, 7.59007679e-01, 4.27834290e-01,
00356   6.78533894e-01, 9.76357610e-01, 4.61789222e-01, 5.16985831e-01,
00357   9.81604707e-01, 4.35318230e-01, 2.06468049e+00, 5.54029894e-01,
00358   6.78015272e-01, 8.53785837e-01, 5.18638945e-01, 1.35733364e+00,
00359   5.37787401e+00, 8.04499038e-01, 7.36510915e-01, 5.12488758e-01,
00360   5.28823677e-01, 7.50000000e-01, 7.27125062e-01, 1.12197569e+00,
00361   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.06393371e-01},
00362  {0.00000000e+00, 1.36359270e+00, 1.06055276e+00, 8.29850973e-01,
00363   9.21480865e-01, 8.82100970e-01, 5.52981315e-01, 9.99248542e-01,
00364   8.22540644e-01, 5.45643330e-01, 8.92977250e-01, 5.10605044e-01,
00365   6.82291911e-01, 1.22434496e+00, 7.59438841e-01, 1.06872445e+00,
00366   8.04499038e-01, 3.14298812e+00, 1.49727124e+00, 6.78664919e-01,
00367   3.92328021e-01, 7.50000000e-01, 6.51019697e-01, 9.53432893e-01,
00368   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.24665180e-01},
00369  {0.00000000e+00, 9.67331593e-01, 9.55438618e-01, 8.17890869e-01,
00370   8.25179634e-01, 8.19031320e-01, 5.70349305e-01, 6.36269018e-01,
00371   6.52641826e-01, 8.60722536e-01, 8.44796364e-01, 7.59171671e-01,
00372   8.82308943e-01, 1.10885139e+00, 7.48565360e-01, 8.10316946e-01,
00373   7.36510915e-01, 1.49727124e+00, 3.55307500e+00, 1.05992520e+00,
00374   5.02669810e-01, 7.50000000e-01, 6.90730891e-01, 8.15700480e-01,
00375   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 7.99921922e-01},
00376  {0.00000000e+00, 9.81625416e-01, 4.46192804e-01, 8.08665030e-01,
00377   4.31712984e-01, 4.79075838e-01, 8.59643167e-01, 4.02720033e-01,
00378   4.13620259e-01, 2.31272269e+00, 5.22802406e-01, 1.32427289e+00,
00379   1.21329921e+00, 4.63246441e-01, 5.24438149e-01, 5.57384267e-01,
00380   5.12488758e-01, 6.78664919e-01, 1.05992520e+00, 3.11745700e+00,
00381   4.84839541e-01, 7.50000000e-01, 7.27350506e-01, 5.09007179e-01,
00382   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 1.72091725e+00},
00383  {0.00000000e+00, 4.63560176e-01, 3.38571955e-01, 3.12131245e-01,
00384   3.07050170e-01, 5.48039829e-01, 1.34807169e+00, 5.04888636e-01,
00385   4.75002356e-01, 5.22495607e-01, 4.61593643e-01, 6.01518374e-01,
00386   7.61522900e-01, 3.75696800e-01, 4.20092966e-01, 7.14705591e-01,
00387   5.28823677e-01, 3.92328021e-01, 5.02669810e-01, 4.84839541e-01,
00388   3.13609332e+01, 7.50000000e-01, 1.76515899e+00, 6.11743441e-01,
00389   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 5.69808181e-01},
00390  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00391   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00392   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00393   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00394   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00395   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00396   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 7.50000000e-01},
00397  {0.00000000e+00, 5.96400452e-01, 5.55905269e-01, 5.38704705e-01,
00398   5.04473723e-01, 6.51686488e-01, 2.42442622e+00, 4.67274430e-01,
00399   1.57000854e+00, 8.26095669e-01, 6.67754286e-01, 8.58373419e-01,
00400   9.17831903e-01, 6.16478872e-01, 4.68173126e-01, 7.42076535e-01,
00401   7.27125062e-01, 6.51019697e-01, 6.90730891e-01, 7.27350506e-01,
00402   1.76515899e+00, 7.50000000e-01, 6.89283261e+00, 6.86235710e-01,
00403   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 8.45421029e-01},
00404  {0.00000000e+00, 8.05980349e-01, 1.19634119e+00, 4.65687383e-01,
00405   1.39378711e+00, 3.38012103e+00, 4.41115461e-01, 5.78707493e-01,
00406   1.02524740e+00, 4.48849604e-01, 1.36451940e+00, 5.10730048e-01,
00407   7.40717150e-01, 9.63798879e-01, 8.05053001e-01, 2.82790659e+00,
00408   1.12197569e+00, 9.53432893e-01, 8.15700480e-01, 5.09007179e-01,
00409   6.11743441e-01, 7.50000000e-01, 6.86235710e-01, 3.16905156e+00,
00410   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 4.85898712e-01},
00411  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00412   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00413   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00414   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00415   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00416   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00417   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 7.50000000e-01},
00418  {0.00000000e+00, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00419   2.90000000e-01, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00420   2.90000000e-01, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00421   2.90000000e-01, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00422   2.90000000e-01, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00423   2.90000000e-01, 2.90000000e-01, 2.90000000e-01, 2.90000000e-01,
00424   2.90000000e-01, 1.33300000e+00, 2.90000000e-01, 2.90000000e-01},
00425  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00426   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00427   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00428   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00429   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00430   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00431   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 7.50000000e-01},
00432  {0.00000000e+00, 6.80310043e-01, 3.97605526e-01, 6.24838486e-01,
00433   3.71809285e-01, 4.53200481e-01, 1.15257995e+00, 3.74281590e-01,
00434   4.92911793e-01, 2.38463611e+00, 4.74822110e-01, 2.67352044e+00,
00435   1.64874201e+00, 4.27987098e-01, 4.70775405e-01, 5.38747839e-01,
00436   5.06393371e-01, 5.24665180e-01, 7.99921922e-01, 1.72091725e+00,
00437   5.69808181e-01, 7.50000000e-01, 8.45421029e-01, 4.85898712e-01,
00438   7.50000000e-01, 2.90000000e-01, 7.50000000e-01, 2.55759716e+00}};
00439 
00440 
00441 /** Underlying frequency ratios for BLOSUM62 */
00442 static const double BLOSUM62_FREQRATIOS[BLASTAA_SIZE][BLASTAA_SIZE] =
00443 {{0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00444   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00445   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00446   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00447   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00448   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00449   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00},
00450  {0.00000000e+00, 3.90294070e+00, 5.64459671e-01, 8.67987664e-01,
00451   5.44605275e-01, 7.41264113e-01, 4.64893827e-01, 1.05686961e+00,
00452   5.69364849e-01, 6.32481035e-01, 7.75390239e-01, 6.01945975e-01,
00453   7.23150342e-01, 5.88307640e-01, 7.54121369e-01, 7.56803943e-01,
00454   6.12698600e-01, 1.47210399e+00, 9.84401956e-01, 9.36458396e-01,
00455   4.16548781e-01, 7.50000000e-01, 5.42611869e-01, 7.47274948e-01,
00456   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 6.14377313e-01},
00457  {0.00000000e+00, 5.64459671e-01, 4.43758048e+00, 3.45226274e-01,
00458   4.74290926e+00, 1.33503378e+00, 3.24101420e-01, 7.38524318e-01,
00459   9.25449581e-01, 3.33981361e-01, 8.54849426e-01, 2.97257620e-01,
00460   4.04640322e-01, 4.07083696e+00, 5.53838329e-01, 9.44103648e-01,
00461   7.02873767e-01, 1.05798620e+00, 8.26250098e-01, 3.51280513e-01,
00462   2.52855433e-01, 7.50000000e-01, 4.09444638e-01, 1.18382127e+00,
00463   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 3.12208474e-01},
00464  {0.00000000e+00, 8.67987664e-01, 3.45226274e-01, 1.95765857e+01,
00465   3.01454345e-01, 2.85934574e-01, 4.38990118e-01, 4.20387870e-01,
00466   3.55049505e-01, 6.53458801e-01, 3.49128465e-01, 6.42275633e-01,
00467   6.11354340e-01, 3.97802620e-01, 3.79562691e-01, 3.65781531e-01,
00468   3.08939296e-01, 7.38415701e-01, 7.40551692e-01, 7.55844055e-01,
00469   4.49983903e-01, 7.50000000e-01, 4.34203398e-01, 3.16819526e-01,
00470   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 6.46828489e-01},
00471  {0.00000000e+00, 5.44605275e-01, 4.74290926e+00, 3.01454345e-01,
00472   7.39792738e+00, 1.68781075e+00, 2.98969081e-01, 6.34301019e-01,
00473   6.78558839e-01, 3.39015407e-01, 7.84090406e-01, 2.86613046e-01,
00474   3.46454634e-01, 1.55385281e+00, 5.98716826e-01, 8.97081129e-01,
00475   5.73200024e-01, 9.13504624e-01, 6.94789868e-01, 3.36500142e-01,
00476   2.32102315e-01, 7.50000000e-01, 3.45683565e-01, 1.38195506e+00,
00477   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 3.07946931e-01},
00478  {0.00000000e+00, 7.41264113e-01, 1.33503378e+00, 2.85934574e-01,
00479   1.68781075e+00, 5.46952608e+00, 3.30743991e-01, 4.81267655e-01,
00480   9.60040718e-01, 3.30522558e-01, 1.30827885e+00, 3.72873704e-01,
00481   5.00342289e-01, 9.11298183e-01, 6.79202587e-01, 1.90173784e+00,
00482   9.60797602e-01, 9.50357185e-01, 7.41425610e-01, 4.28943130e-01,
00483   3.74300212e-01, 7.50000000e-01, 4.96467354e-01, 4.08949895e+00,
00484   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 3.55631838e-01},
00485  {0.00000000e+00, 4.64893827e-01, 3.24101420e-01, 4.38990118e-01,
00486   2.98969081e-01, 3.30743991e-01, 8.12879702e+00, 3.40640908e-01,
00487   6.51990521e-01, 9.45769883e-01, 3.44043119e-01, 1.15459749e+00,
00488   1.00437163e+00, 3.54288952e-01, 2.87444758e-01, 3.33972402e-01,
00489   3.80726330e-01, 4.39973597e-01, 4.81693683e-01, 7.45089738e-01,
00490   1.37437942e+00, 7.50000000e-01, 2.76938063e+00, 3.31992746e-01,
00491   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 1.06958025e+00},
00492  {0.00000000e+00, 1.05686961e+00, 7.38524318e-01, 4.20387870e-01,
00493   6.34301019e-01, 4.81267655e-01, 3.40640908e-01, 6.87630691e+00,
00494   4.92966576e-01, 2.75009722e-01, 5.88871736e-01, 2.84504012e-01,
00495   3.95486600e-01, 8.63711406e-01, 4.77385507e-01, 5.38649627e-01,
00496   4.49983999e-01, 9.03596525e-01, 5.79271582e-01, 3.36954912e-01,
00497   4.21690355e-01, 7.50000000e-01, 3.48714366e-01, 5.03463109e-01,
00498   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 2.80638726e-01},
00499  {0.00000000e+00, 5.69364849e-01, 9.25449581e-01, 3.55049505e-01,
00500   6.78558839e-01, 9.60040718e-01, 6.51990521e-01, 4.92966576e-01,
00501   1.35059997e+01, 3.26288125e-01, 7.78887490e-01, 3.80675486e-01,
00502   5.84132623e-01, 1.22200067e+00, 4.72879831e-01, 1.16798104e+00,
00503   9.17048021e-01, 7.36731740e-01, 5.57503254e-01, 3.39447442e-01,
00504   4.44088955e-01, 7.50000000e-01, 1.79790413e+00, 1.04047242e+00,
00505   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 3.58533474e-01},
00506  {0.00000000e+00, 6.32481035e-01, 3.33981361e-01, 6.53458801e-01,
00507   3.39015407e-01, 3.30522558e-01, 9.45769883e-01, 2.75009722e-01,
00508   3.26288125e-01, 3.99792994e+00, 3.96372934e-01, 1.69443475e+00,
00509   1.47774450e+00, 3.27934752e-01, 3.84662860e-01, 3.82937802e-01,
00510   3.54751311e-01, 4.43163582e-01, 7.79816110e-01, 2.41751209e+00,
00511   4.08874390e-01, 7.50000000e-01, 6.30388931e-01, 3.50796872e-01,
00512   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 2.63222650e+00},
00513  {0.00000000e+00, 7.75390239e-01, 8.54849426e-01, 3.49128465e-01,
00514   7.84090406e-01, 1.30827885e+00, 3.44043119e-01, 5.88871736e-01,
00515   7.78887490e-01, 3.96372934e-01, 4.76433717e+00, 4.28270363e-01,
00516   6.25302816e-01, 9.39841129e-01, 7.03774479e-01, 1.55432308e+00,
00517   2.07680867e+00, 9.31919141e-01, 7.92905803e-01, 4.56542720e-01,
00518   3.58930071e-01, 7.50000000e-01, 5.32179333e-01, 1.40344922e+00,
00519   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 4.15284382e-01},
00520  {0.00000000e+00, 6.01945975e-01, 2.97257620e-01, 6.42275633e-01,
00521   2.86613046e-01, 3.72873704e-01, 1.15459749e+00, 2.84504012e-01,
00522   3.80675486e-01, 1.69443475e+00, 4.28270363e-01, 3.79662137e+00,
00523   1.99429557e+00, 3.10043276e-01, 3.71121724e-01, 4.77325586e-01,
00524   4.73919278e-01, 4.28893743e-01, 6.60328975e-01, 1.31423573e+00,
00525   5.68037074e-01, 7.50000000e-01, 6.92059423e-01, 4.13275887e-01,
00526   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 2.94078574e+00},
00527  {0.00000000e+00, 7.23150342e-01, 4.04640322e-01, 6.11354340e-01,
00528   3.46454634e-01, 5.00342289e-01, 1.00437163e+00, 3.95486600e-01,
00529   5.84132623e-01, 1.47774450e+00, 6.25302816e-01, 1.99429557e+00,
00530   6.48145121e+00, 4.74529655e-01, 4.23898024e-01, 8.64250293e-01,
00531   6.22623369e-01, 5.98558924e-01, 7.93801616e-01, 1.26893679e+00,
00532   6.10296214e-01, 7.50000000e-01, 7.08364628e-01, 6.41102583e-01,
00533   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 1.78399892e+00},
00534  {0.00000000e+00, 5.88307640e-01, 4.07083696e+00, 3.97802620e-01,
00535   1.55385281e+00, 9.11298183e-01, 3.54288952e-01, 8.63711406e-01,
00536   1.22200067e+00, 3.27934752e-01, 9.39841129e-01, 3.10043276e-01,
00537   4.74529655e-01, 7.09409488e+00, 4.99932836e-01, 1.00058442e+00,
00538   8.58630478e-01, 1.23152924e+00, 9.84152635e-01, 3.69033853e-01,
00539   2.77782896e-01, 7.50000000e-01, 4.86030806e-01, 9.45834265e-01,
00540   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 3.17327197e-01},
00541  {0.00000000e+00, 7.54121369e-01, 5.53838329e-01, 3.79562691e-01,
00542   5.98716826e-01, 6.79202587e-01, 2.87444758e-01, 4.77385507e-01,
00543   4.72879831e-01, 3.84662860e-01, 7.03774479e-01, 3.71121724e-01,
00544   4.23898024e-01, 4.99932836e-01, 1.28375437e+01, 6.41280589e-01,
00545   4.81534905e-01, 7.55503259e-01, 6.88897122e-01, 4.43082984e-01,
00546   2.81833164e-01, 7.50000000e-01, 3.63521119e-01, 6.64534287e-01,
00547   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 3.76634549e-01},
00548  {0.00000000e+00, 7.56803943e-01, 9.44103648e-01, 3.65781531e-01,
00549   8.97081129e-01, 1.90173784e+00, 3.33972402e-01, 5.38649627e-01,
00550   1.16798104e+00, 3.82937802e-01, 1.55432308e+00, 4.77325586e-01,
00551   8.64250293e-01, 1.00058442e+00, 6.41280589e-01, 6.24442175e+00,
00552   1.40579606e+00, 9.65555228e-01, 7.91320741e-01, 4.66777931e-01,
00553   5.09360272e-01, 7.50000000e-01, 6.11094097e-01, 3.58149606e+00,
00554   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 4.38898727e-01},
00555  {0.00000000e+00, 6.12698600e-01, 7.02873767e-01, 3.08939296e-01,
00556   5.73200024e-01, 9.60797602e-01, 3.80726330e-01, 4.49983999e-01,
00557   9.17048021e-01, 3.54751311e-01, 2.07680867e+00, 4.73919278e-01,
00558   6.22623369e-01, 8.58630478e-01, 4.81534905e-01, 1.40579606e+00,
00559   6.66557707e+00, 7.67165633e-01, 6.77754679e-01, 4.20072316e-01,
00560   3.95102106e-01, 7.50000000e-01, 5.55965425e-01, 1.13292384e+00,
00561   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 4.25403989e-01},
00562  {0.00000000e+00, 1.47210399e+00, 1.05798620e+00, 7.38415701e-01,
00563   9.13504624e-01, 9.50357185e-01, 4.39973597e-01, 9.03596525e-01,
00564   7.36731740e-01, 4.43163582e-01, 9.31919141e-01, 4.28893743e-01,
00565   5.98558924e-01, 1.23152924e+00, 7.55503259e-01, 9.65555228e-01,
00566   7.67165633e-01, 3.84284741e+00, 1.61392097e+00, 5.65223766e-01,
00567   3.85303035e-01, 7.50000000e-01, 5.57520051e-01, 9.56235816e-01,
00568   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 4.34703235e-01},
00569  {0.00000000e+00, 9.84401956e-01, 8.26250098e-01, 7.40551692e-01,
00570   6.94789868e-01, 7.41425610e-01, 4.81693683e-01, 5.79271582e-01,
00571   5.57503254e-01, 7.79816110e-01, 7.92905803e-01, 6.60328975e-01,
00572   7.93801616e-01, 9.84152635e-01, 6.88897122e-01, 7.91320741e-01,
00573   6.77754679e-01, 1.61392097e+00, 4.83210516e+00, 9.80943005e-01,
00574   4.30934144e-01, 7.50000000e-01, 5.73156574e-01, 7.60725140e-01,
00575   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 7.08974203e-01},
00576  {0.00000000e+00, 9.36458396e-01, 3.51280513e-01, 7.55844055e-01,
00577   3.36500142e-01, 4.28943130e-01, 7.45089738e-01, 3.36954912e-01,
00578   3.39447442e-01, 2.41751209e+00, 4.56542720e-01, 1.31423573e+00,
00579   1.26893679e+00, 3.69033853e-01, 4.43082984e-01, 4.66777931e-01,
00580   4.20072316e-01, 5.65223766e-01, 9.80943005e-01, 3.69215640e+00,
00581   3.74456332e-01, 7.50000000e-01, 6.58038693e-01, 4.43577702e-01,
00582   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 1.76339815e+00},
00583  {0.00000000e+00, 4.16548781e-01, 2.52855433e-01, 4.49983903e-01,
00584   2.32102315e-01, 3.74300212e-01, 1.37437942e+00, 4.21690355e-01,
00585   4.44088955e-01, 4.08874390e-01, 3.58930071e-01, 5.68037074e-01,
00586   6.10296214e-01, 2.77782896e-01, 2.81833164e-01, 5.09360272e-01,
00587   3.95102106e-01, 3.85303035e-01, 4.30934144e-01, 3.74456332e-01,
00588   3.81077833e+01, 7.50000000e-01, 2.10980812e+00, 4.26541694e-01,
00589   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 5.03239261e-01},
00590  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00591   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00592   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00593   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00594   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00595   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00596   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 7.50000000e-01},
00597  {0.00000000e+00, 5.42611869e-01, 4.09444638e-01, 4.34203398e-01,
00598   3.45683565e-01, 4.96467354e-01, 2.76938063e+00, 3.48714366e-01,
00599   1.79790413e+00, 6.30388931e-01, 5.32179333e-01, 6.92059423e-01,
00600   7.08364628e-01, 4.86030806e-01, 3.63521119e-01, 6.11094097e-01,
00601   5.55965425e-01, 5.57520051e-01, 5.73156574e-01, 6.58038693e-01,
00602   2.10980812e+00, 7.50000000e-01, 9.83220341e+00, 5.40805192e-01,
00603   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 6.66952325e-01},
00604  {0.00000000e+00, 7.47274948e-01, 1.18382127e+00, 3.16819526e-01,
00605   1.38195506e+00, 4.08949895e+00, 3.31992746e-01, 5.03463109e-01,
00606   1.04047242e+00, 3.50796872e-01, 1.40344922e+00, 4.13275887e-01,
00607   6.41102583e-01, 9.45834265e-01, 6.64534287e-01, 3.58149606e+00,
00608   1.13292384e+00, 9.56235816e-01, 7.60725140e-01, 4.43577702e-01,
00609   4.26541694e-01, 7.50000000e-01, 5.40805192e-01, 3.89300249e+00,
00610   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 3.87839626e-01},
00611  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00612   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00613   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00614   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00615   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00616   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00617   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 7.50000000e-01},
00618  {0.00000000e+00, 2.50000000e-01, 2.50000000e-01, 2.50000000e-01,
00619   2.50000000e-01, 2.50000000e-01, 2.50000000e-01, 2.50000000e-01,
00620   2.50000000e-01, 2.50000000e-01, 2.50000000e-01, 2.50000000e-01,
00621   2.50000000e-01, 2.50000000e-01, 2.50000000e-01, 2.50000000e-01,
00622   2.50000000e-01, 2.50000000e-01, 2.50000000e-01, 2.50000000e-01,
00623   2.50000000e-01, 2.50000000e-01, 2.50000000e-01, 2.50000000e-01,
00624   2.50000000e-01, 1.33300000e+00, 2.50000000e-01, 2.50000000e-01},
00625  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00626   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00627   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00628   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00629   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00630   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00631   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 7.50000000e-01},
00632  {0.00000000e+00, 6.14377313e-01, 3.12208474e-01, 6.46828489e-01,
00633   3.07946931e-01, 3.55631838e-01, 1.06958025e+00, 2.80638726e-01,
00634   3.58533474e-01, 2.63222650e+00, 4.15284382e-01, 2.94078574e+00,
00635   1.78399892e+00, 3.17327197e-01, 3.76634549e-01, 4.38898727e-01,
00636   4.25403989e-01, 4.34703235e-01, 7.08974203e-01, 1.76339815e+00,
00637   5.03239261e-01, 7.50000000e-01, 6.66952325e-01, 3.87839626e-01,
00638   7.50000000e-01, 2.50000000e-01, 7.50000000e-01, 2.81516607e+00}};
00639 
00640 
00641 /** Underlying frequency ratios for BLOSUM80 */
00642 static const double BLOSUM80_FREQRATIOS[BLASTAA_SIZE][BLASTAA_SIZE] =
00643 {{0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00644   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00645   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00646   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00647   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00648   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00649   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00},
00650  {0.00000000e+00, 4.77313697e+00, 4.77250219e-01, 7.31790935e-01,
00651   4.50905428e-01, 7.03141318e-01, 3.96805472e-01, 9.57108118e-01,
00652   5.14428496e-01, 5.43302985e-01, 7.22895459e-01, 5.04576848e-01,
00653   6.25509899e-01, 5.10109254e-01, 7.71095354e-01, 6.95763501e-01,
00654   5.55324683e-01, 1.53463504e+00, 9.79634362e-01, 8.65874830e-01,
00655   3.09281009e-01, 7.50000000e-01, 4.36234494e-01, 7.00327585e-01,
00656   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 5.20181427e-01},
00657  {0.00000000e+00, 4.77250219e-01, 5.36249708e+00, 2.52383415e-01,
00658   5.75921529e+00, 1.26868736e+00, 2.51452613e-01, 6.38679494e-01,
00659   8.30167261e-01, 2.33516284e-01, 7.93249084e-01, 2.20539708e-01,
00660   3.09639510e-01, 4.86768283e+00, 4.28138134e-01, 8.50001386e-01,
00661   6.08526572e-01, 9.48166786e-01, 7.43109762e-01, 2.67977796e-01,
00662   1.78830543e-01, 7.50000000e-01, 3.07187296e-01, 1.10900996e+00,
00663   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 2.25768580e-01},
00664  {0.00000000e+00, 7.31790935e-01, 2.52383415e-01, 2.07020176e+01,
00665   2.13899571e-01, 1.79625278e-01, 3.94756499e-01, 2.72055621e-01,
00666   2.21322329e-01, 5.81174860e-01, 2.41148280e-01, 4.92657548e-01,
00667   4.99414247e-01, 3.00383113e-01, 2.69170214e-01, 2.95117493e-01,
00668   2.32476995e-01, 5.76114817e-01, 6.01733396e-01, 6.34451252e-01,
00669   3.02232769e-01, 7.50000000e-01, 3.07930831e-01, 2.23671408e-01,
00670   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 5.28325329e-01},
00671  {0.00000000e+00, 4.50905428e-01, 5.75921529e+00, 2.13899571e-01,
00672   9.10634223e+00, 1.63552603e+00, 2.34434106e-01, 5.40654444e-01,
00673   5.94384672e-01, 2.14047157e-01, 6.76875328e-01, 1.97166761e-01,
00674   2.51946380e-01, 1.58444827e+00, 4.52407652e-01, 7.63275386e-01,
00675   4.76639455e-01, 7.74041684e-01, 6.10882957e-01, 2.44693975e-01,
00676   1.44774364e-01, 7.50000000e-01, 2.45193294e-01, 1.30286928e+00,
00677   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 2.03968665e-01},
00678  {0.00000000e+00, 7.03141318e-01, 1.26868736e+00, 1.79625278e-01,
00679   1.63552603e+00, 6.99475019e+00, 2.48970812e-01, 3.99359878e-01,
00680   9.01259830e-01, 2.64258683e-01, 1.19492933e+00, 2.75527698e-01,
00681   4.28576433e-01, 8.11140936e-01, 5.81414067e-01, 1.90643780e+00,
00682   8.31863127e-01, 8.45039731e-01, 6.85529376e-01, 3.69379335e-01,
00683   2.40807712e-01, 7.50000000e-01, 3.32874109e-01, 5.05418243e+00,
00684   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 2.70986883e-01},
00685  {0.00000000e+00, 3.96805472e-01, 2.51452613e-01, 3.94756499e-01,
00686   2.34434106e-01, 2.48970812e-01, 9.48547379e+00, 2.48796540e-01,
00687   5.71854758e-01, 8.40573731e-01, 2.82718808e-01, 1.11429351e+00,
00688   8.93330223e-01, 2.72679266e-01, 2.37160811e-01, 2.85158291e-01,
00689   2.87269045e-01, 3.69100895e-01, 4.45199900e-01, 6.48888163e-01,
00690   1.08939386e+00, 7.50000000e-01, 2.78024963e+00, 2.62771902e-01,
00691   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 1.00399896e+00},
00692  {0.00000000e+00, 9.57108118e-01, 6.38679494e-01, 2.72055621e-01,
00693   5.40654444e-01, 3.99359878e-01, 2.48796540e-01, 7.88244144e+00,
00694   3.87151686e-01, 1.84455102e-01, 4.83435068e-01, 2.10542976e-01,
00695   2.86067872e-01, 7.60943081e-01, 3.47300820e-01, 4.24585221e-01,
00696   3.77442786e-01, 7.84315177e-01, 4.92238430e-01, 2.50954947e-01,
00697   2.64396616e-01, 7.50000000e-01, 2.29516029e-01, 4.08980256e-01,
00698   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 2.00030947e-01},
00699  {0.00000000e+00, 5.14428496e-01, 8.30167261e-01, 2.21322329e-01,
00700   5.94384672e-01, 9.01259830e-01, 5.71854758e-01, 3.87151686e-01,
00701   1.60694674e+01, 2.57933576e-01, 7.40110055e-01, 3.14299881e-01,
00702   4.32076355e-01, 1.12425153e+00, 4.19656882e-01, 1.31555625e+00,
00703   9.25536475e-01, 6.61407005e-01, 5.39570743e-01, 2.88933760e-01,
00704   3.90225420e-01, 7.50000000e-01, 1.81930455e+00, 1.05926315e+00,
00705   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 2.91587251e-01},
00706  {0.00000000e+00, 5.43302985e-01, 2.33516284e-01, 5.81174860e-01,
00707   2.14047157e-01, 2.64258683e-01, 8.40573731e-01, 1.84455102e-01,
00708   2.57933576e-01, 4.86762150e+00, 3.13345237e-01, 1.66499837e+00,
00709   1.51247384e+00, 2.57799519e-01, 2.85790430e-01, 3.09071252e-01,
00710   2.99348100e-01, 3.78995471e-01, 7.00511896e-01, 2.49584558e+00,
00711   3.43150987e-01, 7.50000000e-01, 5.39308441e-01, 2.81349188e-01,
00712   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 2.95548558e+00},
00713  {0.00000000e+00, 7.22895459e-01, 7.93249084e-01, 2.41148280e-01,
00714   6.76875328e-01, 1.19492933e+00, 2.82718808e-01, 4.83435068e-01,
00715   7.40110055e-01, 3.13345237e-01, 6.32564527e+00, 3.56851811e-01,
00716   5.34403407e-01, 9.38398440e-01, 5.96694133e-01, 1.52403165e+00,
00717   2.19214139e+00, 8.20193974e-01, 7.35729790e-01, 3.70194033e-01,
00718   2.41427653e-01, 7.50000000e-01, 4.08501941e-01, 1.32044155e+00,
00719   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 3.39320970e-01},
00720  {0.00000000e+00, 5.04576848e-01, 2.20539708e-01, 4.92657548e-01,
00721   1.97166761e-01, 2.75527698e-01, 1.11429351e+00, 2.10542976e-01,
00722   3.14299881e-01, 1.66499837e+00, 3.56851811e-01, 4.46305621e+00,
00723   2.12274889e+00, 2.49692056e-01, 3.03099202e-01, 4.06904090e-01,
00724   3.62830591e-01, 3.68478686e-01, 5.60836408e-01, 1.22050154e+00,
00725   4.38789464e-01, 7.50000000e-01, 5.80503535e-01, 3.25631695e-01,
00726   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 3.33558735e+00},
00727  {0.00000000e+00, 6.25509899e-01, 3.09639510e-01, 4.99414247e-01,
00728   2.51946380e-01, 4.28576433e-01, 8.93330223e-01, 2.86067872e-01,
00729   4.32076355e-01, 1.51247384e+00, 5.34403407e-01, 2.12274889e+00,
00730   8.88346290e+00, 3.81598352e-01, 3.61925345e-01, 8.86557630e-01,
00731   5.05866341e-01, 4.98438721e-01, 7.57959723e-01, 1.22414515e+00,
00732   5.60653516e-01, 7.50000000e-01, 5.49937808e-01, 6.03240148e-01,
00733   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 1.87684042e+00},
00734  {0.00000000e+00, 5.10109254e-01, 4.86768283e+00, 3.00383113e-01,
00735   1.58444827e+00, 8.11140936e-01, 2.72679266e-01, 7.60943081e-01,
00736   1.12425153e+00, 2.57799519e-01, 9.38398440e-01, 2.49692056e-01,
00737   3.81598352e-01, 8.96275887e+00, 3.97867522e-01, 9.58172021e-01,
00738   7.73025258e-01, 1.16534759e+00, 9.08032132e-01, 2.97018980e-01,
00739   2.21307752e-01, 7.50000000e-01, 3.84510481e-01, 8.67215281e-01,
00740   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 2.52958933e-01},
00741  {0.00000000e+00, 7.71095354e-01, 4.28138134e-01, 2.69170214e-01,
00742   4.52407652e-01, 5.81414067e-01, 2.37160811e-01, 3.47300820e-01,
00743   4.19656882e-01, 2.85790430e-01, 5.96694133e-01, 3.03099202e-01,
00744   3.61925345e-01, 3.97867522e-01, 1.51545798e+01, 5.37994539e-01,
00745   4.45589871e-01, 6.51704179e-01, 5.60357280e-01, 3.70233083e-01,
00746   1.78033069e-01, 7.50000000e-01, 2.57545983e-01, 5.64854837e-01,
00747   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 2.96124685e-01},
00748  {0.00000000e+00, 6.95763501e-01, 8.50001386e-01, 2.95117493e-01,
00749   7.63275386e-01, 1.90643780e+00, 2.85158291e-01, 4.24585221e-01,
00750   1.31555625e+00, 3.09071252e-01, 1.52403165e+00, 4.06904090e-01,
00751   8.86557630e-01, 9.58172021e-01, 5.37994539e-01, 8.33990474e+00,
00752   1.39424540e+00, 8.58988713e-01, 7.24369298e-01, 4.10943414e-01,
00753   4.07901262e-01, 7.50000000e-01, 4.61857147e-01, 4.36001721e+00,
00754   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 3.67482647e-01},
00755  {0.00000000e+00, 5.55324683e-01, 6.08526572e-01, 2.32476995e-01,
00756   4.76639455e-01, 8.31863127e-01, 2.87269045e-01, 3.77442786e-01,
00757   9.25536475e-01, 2.99348100e-01, 2.19214139e+00, 3.62830591e-01,
00758   5.05866341e-01, 7.73025258e-01, 4.45589871e-01, 1.39424540e+00,
00759   8.24459589e+00, 6.94509540e-01, 5.98385216e-01, 3.53719047e-01,
00760   2.94245493e-01, 7.50000000e-01, 4.17775411e-01, 1.04634306e+00,
00761   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 3.37250515e-01},
00762  {0.00000000e+00, 1.53463504e+00, 9.48166786e-01, 5.76114817e-01,
00763   7.74041684e-01, 8.45039731e-01, 3.69100895e-01, 7.84315177e-01,
00764   6.61407005e-01, 3.78995471e-01, 8.20193974e-01, 3.68478686e-01,
00765   4.98438721e-01, 1.16534759e+00, 6.51704179e-01, 8.58988713e-01,
00766   6.94509540e-01, 5.10577131e+00, 1.66260189e+00, 4.93679246e-01,
00767   2.70773669e-01, 7.50000000e-01, 4.62005069e-01, 8.50359559e-01,
00768   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 3.72716393e-01},
00769  {0.00000000e+00, 9.79634362e-01, 7.43109762e-01, 6.01733396e-01,
00770   6.10882957e-01, 6.85529376e-01, 4.45199900e-01, 4.92238430e-01,
00771   5.39570743e-01, 7.00511896e-01, 7.35729790e-01, 5.60836408e-01,
00772   7.57959723e-01, 9.08032132e-01, 5.60357280e-01, 7.24369298e-01,
00773   5.98385216e-01, 1.66260189e+00, 6.20547751e+00, 8.91492247e-01,
00774   2.85084781e-01, 7.50000000e-01, 4.74451641e-01, 7.00342047e-01,
00775   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 6.17118219e-01},
00776  {0.00000000e+00, 8.65874830e-01, 2.67977796e-01, 6.34451252e-01,
00777   2.44693975e-01, 3.69379335e-01, 6.48888163e-01, 2.50954947e-01,
00778   2.88933760e-01, 2.49584558e+00, 3.70194033e-01, 1.22050154e+00,
00779   1.22414515e+00, 2.97018980e-01, 3.70233083e-01, 4.10943414e-01,
00780   3.53719047e-01, 4.93679246e-01, 8.91492247e-01, 4.58356287e+00,
00781   3.42175943e-01, 7.50000000e-01, 4.89223745e-01, 3.85230939e-01,
00782   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 1.73439753e+00},
00783  {0.00000000e+00, 3.09281009e-01, 1.78830543e-01, 3.02232769e-01,
00784   1.44774364e-01, 2.40807712e-01, 1.08939386e+00, 2.64396616e-01,
00785   3.90225420e-01, 3.43150987e-01, 2.41427653e-01, 4.38789464e-01,
00786   5.60653516e-01, 2.21307752e-01, 1.78033069e-01, 4.07901262e-01,
00787   2.94245493e-01, 2.70773669e-01, 2.85084781e-01, 3.42175943e-01,
00788   4.15522183e+01, 7.50000000e-01, 2.03605072e+00, 3.04533429e-01,
00789   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 4.00252232e-01},
00790  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00791   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00792   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00793   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00794   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00795   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00796   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 7.50000000e-01},
00797  {0.00000000e+00, 4.36234494e-01, 3.07187296e-01, 3.07930831e-01,
00798   2.45193294e-01, 3.32874109e-01, 2.78024963e+00, 2.29516029e-01,
00799   1.81930455e+00, 5.39308441e-01, 4.08501941e-01, 5.80503535e-01,
00800   5.49937808e-01, 3.84510481e-01, 2.57545983e-01, 4.61857147e-01,
00801   4.17775411e-01, 4.62005069e-01, 4.74451641e-01, 4.89223745e-01,
00802   2.03605072e+00, 7.50000000e-01, 1.21940332e+01, 3.82065335e-01,
00803   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 5.63904098e-01},
00804  {0.00000000e+00, 7.00327585e-01, 1.10900996e+00, 2.23671408e-01,
00805   1.30286928e+00, 5.05418243e+00, 2.62771902e-01, 4.08980256e-01,
00806   1.05926315e+00, 2.81349188e-01, 1.32044155e+00, 3.25631695e-01,
00807   6.03240148e-01, 8.67215281e-01, 5.64854837e-01, 4.36001721e+00,
00808   1.04634306e+00, 8.50359559e-01, 7.00342047e-01, 3.85230939e-01,
00809   3.04533429e-01, 7.50000000e-01, 3.82065335e-01, 4.78944345e+00,
00810   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 3.07788194e-01},
00811  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00812   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00813   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00814   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00815   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00816   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00817   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 7.50000000e-01},
00818  {0.00000000e+00, 1.40000000e-01, 1.40000000e-01, 1.40000000e-01,
00819   1.40000000e-01, 1.40000000e-01, 1.40000000e-01, 1.40000000e-01,
00820   1.40000000e-01, 1.40000000e-01, 1.40000000e-01, 1.40000000e-01,
00821   1.40000000e-01, 1.40000000e-01, 1.40000000e-01, 1.40000000e-01,
00822   1.40000000e-01, 1.40000000e-01, 1.40000000e-01, 1.40000000e-01,
00823   1.40000000e-01, 1.40000000e-01, 1.40000000e-01, 1.40000000e-01,
00824   1.40000000e-01, 1.33300000e+00, 1.40000000e-01, 1.40000000e-01},
00825  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00826   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00827   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00828   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00829   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00830   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00831   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 7.50000000e-01},
00832  {0.00000000e+00, 5.20181427e-01, 2.25768580e-01, 5.28325329e-01,
00833   2.03968665e-01, 2.70986883e-01, 1.00399896e+00, 2.00030947e-01,
00834   2.91587251e-01, 2.95548558e+00, 3.39320970e-01, 3.33558735e+00,
00835   1.87684042e+00, 2.52958933e-01, 2.96124685e-01, 3.67482647e-01,
00836   3.37250515e-01, 3.72716393e-01, 6.17118219e-01, 1.73439753e+00,
00837   4.00252232e-01, 7.50000000e-01, 5.63904098e-01, 3.07788194e-01,
00838   7.50000000e-01, 1.40000000e-01, 7.50000000e-01, 3.18242650e+00}};
00839 
00840 
00841 /** Underlying frequency ratios for BLOSUM90 */
00842 static const double BLOSUM90_FREQRATIOS[BLASTAA_SIZE][BLASTAA_SIZE] =
00843 {{0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00844   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00845   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00846   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00847   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00848   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
00849   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00},
00850  {0.00000000e+00, 5.49812903e+00, 4.38682591e-01, 6.69393543e-01,
00851   4.10593787e-01, 6.67362415e-01, 3.46907686e-01, 8.55253386e-01,
00852   4.61993747e-01, 4.75838329e-01, 6.64089300e-01, 4.46304927e-01,
00853   5.48948177e-01, 4.75350260e-01, 7.12075051e-01, 6.37043670e-01,
00854   5.31189855e-01, 1.45279278e+00, 9.34706358e-01, 7.93712275e-01,
00855   2.83637106e-01, 7.50000000e-01, 3.70274337e-01, 6.55892238e-01,
00856   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 4.58271706e-01},
00857  {0.00000000e+00, 4.38682591e-01, 5.85593083e+00, 2.24322103e-01,
00858   6.24911512e+00, 1.23816514e+00, 2.14608760e-01, 5.64122407e-01,
00859   7.82997018e-01, 1.96621553e-01, 7.38810616e-01, 1.94127812e-01,
00860   2.69937418e-01, 5.34266045e+00, 3.78549747e-01, 7.81147613e-01,
00861   5.45762328e-01, 8.70271567e-01, 6.66528685e-01, 2.28904046e-01,
00862   1.42810925e-01, 7.50000000e-01, 2.77062678e-01, 1.06526643e+00,
00863   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 1.95138263e-01},
00864  {0.00000000e+00, 6.69393543e-01, 2.24322103e-01, 2.16370056e+01,
00865   1.76054992e-01, 1.47039970e-01, 3.92579579e-01, 2.18182122e-01,
00866   1.93552170e-01, 5.20896357e-01, 2.15679622e-01, 4.25126435e-01,
00867   4.27104871e-01, 2.87330927e-01, 2.30151009e-01, 2.42068607e-01,
00868   2.06242089e-01, 5.23756471e-01, 5.48342086e-01, 5.88014943e-01,
00869   2.50594014e-01, 7.50000000e-01, 2.92512133e-01, 1.82991170e-01,
00870   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 4.63931905e-01},
00871  {0.00000000e+00, 4.10593787e-01, 6.24911512e+00, 1.76054992e-01,
00872   9.87094836e+00, 1.61092322e+00, 1.97472144e-01, 4.84699282e-01,
00873   5.46208942e-01, 1.71646922e-01, 6.20942905e-01, 1.71021465e-01,
00874   2.15937410e-01, 1.52110375e+00, 3.99848977e-01, 6.86343892e-01,
00875   4.17577647e-01, 6.96691332e-01, 5.29001708e-01, 2.06199101e-01,
00876   1.15609648e-01, 7.50000000e-01, 2.13739536e-01, 1.26113669e+00,
00877   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 1.71274897e-01},
00878  {0.00000000e+00, 6.67362415e-01, 1.23816514e+00, 1.47039970e-01,
00879   1.61092322e+00, 7.91072600e+00, 2.04920324e-01, 3.47008914e-01,
00880   7.72534981e-01, 2.37473636e-01, 1.07737256e+00, 2.37238651e-01,
00881   3.61519510e-01, 7.51559518e-01, 5.28989676e-01, 1.83144568e+00,
00882   7.31811567e-01, 7.59912485e-01, 6.13331345e-01, 3.33942314e-01,
00883   2.02669731e-01, 7.50000000e-01, 2.73296982e-01, 5.61081481e+00,
00884   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 2.37333866e-01},
00885  {0.00000000e+00, 3.46907686e-01, 2.14608760e-01, 3.92579579e-01,
00886   1.97472144e-01, 2.04920324e-01, 1.05190688e+01, 1.97046381e-01,
00887   5.10867985e-01, 7.73236776e-01, 2.73932585e-01, 1.05058955e+00,
00888   8.11125795e-01, 2.36979230e-01, 2.12448013e-01, 2.80742738e-01,
00889   2.62210098e-01, 3.33306129e-01, 3.90547453e-01, 5.77272331e-01,
00890   9.82154073e-01, 7.50000000e-01, 2.77172979e+00, 2.33605433e-01,
00891   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 9.38207661e-01},
00892  {0.00000000e+00, 8.55253386e-01, 5.64122407e-01, 2.18182122e-01,
00893   4.84699282e-01, 3.47008914e-01, 1.97046381e-01, 8.29576319e+00,
00894   3.35169505e-01, 1.51428808e-01, 4.27685370e-01, 1.83265898e-01,
00895   2.37360208e-01, 6.67802895e-01, 2.98989408e-01, 3.80871171e-01,
00896   3.28608745e-01, 7.00460225e-01, 4.00474342e-01, 2.02269779e-01,
00897   2.34021877e-01, 7.50000000e-01, 1.88904853e-01, 3.59819671e-01,
00898   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 1.70365676e-01},
00899  {0.00000000e+00, 4.61993747e-01, 7.82997018e-01, 1.93552170e-01,
00900   5.46208942e-01, 7.72534981e-01, 5.10867985e-01, 3.35169505e-01,
00901   1.85636930e+01, 2.32236241e-01, 6.80230209e-01, 2.89296785e-01,
00902   4.06641319e-01, 1.09210477e+00, 3.99528365e-01, 1.24778653e+00,
00903   8.70382542e-01, 5.94270003e-01, 4.71855284e-01, 2.49881715e-01,
00904   3.84396440e-01, 7.50000000e-01, 1.62620965e+00, 9.52331980e-01,
00905   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 2.66176152e-01},
00906  {0.00000000e+00, 4.75838329e-01, 1.96621553e-01, 5.20896357e-01,
00907   1.71646922e-01, 2.37473636e-01, 7.73236776e-01, 1.51428808e-01,
00908   2.32236241e-01, 5.62471003e+00, 2.84042165e-01, 1.59032509e+00,
00909   1.47982983e+00, 2.29223921e-01, 2.60766373e-01, 2.80218761e-01,
00910   2.69951432e-01, 3.32350183e-01, 6.20404233e-01, 2.47466358e+00,
00911   2.84494454e-01, 7.50000000e-01, 4.78737209e-01, 2.53644956e-01,
00912   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 3.22503669e+00},
00913  {0.00000000e+00, 6.64089300e-01, 7.38810616e-01, 2.15679622e-01,
00914   6.20942905e-01, 1.07737256e+00, 2.73932585e-01, 4.27685370e-01,
00915   6.80230209e-01, 2.84042165e-01, 7.40971353e+00, 3.18645229e-01,
00916   5.03980900e-01, 8.92677413e-01, 5.54085013e-01, 1.48494120e+00,
00917   2.15988586e+00, 7.31921781e-01, 6.80549543e-01, 3.28415139e-01,
00918   1.74946435e-01, 7.50000000e-01, 3.46172886e-01, 1.23156378e+00,
00919   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 3.04624249e-01},
00920  {0.00000000e+00, 4.46304927e-01, 1.94127812e-01, 4.25126435e-01,
00921   1.71021465e-01, 2.37238651e-01, 1.05058955e+00, 1.83265898e-01,
00922   2.89296785e-01, 1.59032509e+00, 3.18645229e-01, 5.03145573e+00,
00923   2.07702392e+00, 2.24291285e-01, 2.72188366e-01, 3.74709469e-01,
00924   3.26170372e-01, 3.38914311e-01, 5.07385737e-01, 1.13293282e+00,
00925   3.72830750e-01, 7.50000000e-01, 5.08794972e-01, 2.89246563e-01,
00926   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 3.63712766e+00},
00927  {0.00000000e+00, 5.48948177e-01, 2.69937418e-01, 4.27104871e-01,
00928   2.15937410e-01, 3.61519510e-01, 8.11125795e-01, 2.37360208e-01,
00929   4.06641319e-01, 1.47982983e+00, 5.03980900e-01, 2.07702392e+00,
00930   1.13394084e+01, 3.40430076e-01, 3.16108504e-01, 8.49621832e-01,
00931   4.63059321e-01, 4.39100157e-01, 6.79030953e-01, 1.13727027e+00,
00932   4.92730381e-01, 7.50000000e-01, 4.80316866e-01, 5.46178209e-01,
00933   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 1.83504401e+00},
00934  {0.00000000e+00, 4.75350260e-01, 5.34266045e+00, 2.87330927e-01,
00935   1.52110375e+00, 7.51559518e-01, 2.36979230e-01, 6.67802895e-01,
00936   1.09210477e+00, 2.29223921e-01, 8.92677413e-01, 2.24291285e-01,
00937   3.40430076e-01, 1.03313947e+01, 3.50745318e-01, 9.04906229e-01,
00938   7.13097098e-01, 1.09686657e+00, 8.46059068e-01, 2.58543521e-01,
00939   1.78320001e-01, 7.50000000e-01, 3.59725936e-01, 8.09573592e-01,
00940   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 2.26289963e-01},
00941  {0.00000000e+00, 7.12075051e-01, 3.78549747e-01, 2.30151009e-01,
00942   3.99848977e-01, 5.28989676e-01, 2.12448013e-01, 2.98989408e-01,
00943   3.99528365e-01, 2.60766373e-01, 5.54085013e-01, 2.72188366e-01,
00944   3.16108504e-01, 3.50745318e-01, 1.60877707e+01, 4.86643270e-01,
00945   4.09306303e-01, 5.93677872e-01, 4.80576271e-01, 3.23032809e-01,
00946   1.74477792e-01, 7.50000000e-01, 2.13074361e-01, 5.12969199e-01,
00947   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 2.67560235e-01},
00948  {0.00000000e+00, 6.37043670e-01, 7.81147613e-01, 2.42068607e-01,
00949   6.86343892e-01, 1.83144568e+00, 2.80742738e-01, 3.80871171e-01,
00950   1.24778653e+00, 2.80218761e-01, 1.48494120e+00, 3.74709469e-01,
00951   8.49621832e-01, 9.04906229e-01, 4.86643270e-01, 9.98642121e+00,
00952   1.25897253e+00, 7.86784913e-01, 6.71486014e-01, 3.48766905e-01,
00953   3.51106744e-01, 7.50000000e-01, 4.01714365e-01, 4.91663315e+00,
00954   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 3.36422330e-01},
00955  {0.00000000e+00, 5.31189855e-01, 5.45762328e-01, 2.06242089e-01,
00956   4.17577647e-01, 7.31811567e-01, 2.62210098e-01, 3.28608745e-01,
00957   8.70382542e-01, 2.69951432e-01, 2.15988586e+00, 3.26170372e-01,
00958   4.63059321e-01, 7.13097098e-01, 4.09306303e-01, 1.25897253e+00,
00959   9.45518393e+00, 6.27094667e-01, 5.25362150e-01, 3.16415957e-01,
00960   2.48889195e-01, 7.50000000e-01, 3.62347797e-01, 9.31246918e-01,
00961   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 3.03390753e-01},
00962  {0.00000000e+00, 1.45279278e+00, 8.70271567e-01, 5.23756471e-01,
00963   6.96691332e-01, 7.59912485e-01, 3.33306129e-01, 7.00460225e-01,
00964   5.94270003e-01, 3.32350183e-01, 7.31921781e-01, 3.38914311e-01,
00965   4.39100157e-01, 1.09686657e+00, 5.93677872e-01, 7.86784913e-01,
00966   6.27094667e-01, 5.99164849e+00, 1.62868240e+00, 4.49399804e-01,
00967   2.30316670e-01, 7.50000000e-01, 4.11583504e-01, 7.70078852e-01,
00968   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 3.36254561e-01},
00969  {0.00000000e+00, 9.34706358e-01, 6.66528685e-01, 5.48342086e-01,
00970   5.29001708e-01, 6.13331345e-01, 3.90547453e-01, 4.00474342e-01,
00971   4.71855284e-01, 6.20404233e-01, 6.80549543e-01, 5.07385737e-01,
00972   6.79030953e-01, 8.46059068e-01, 4.80576271e-01, 6.71486014e-01,
00973   5.25362150e-01, 1.62868240e+00, 7.25868130e+00, 8.04058132e-01,
00974   2.27083637e-01, 7.50000000e-01, 4.20544390e-01, 6.35332398e-01,
00975   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 5.53180238e-01},
00976  {0.00000000e+00, 7.93712275e-01, 2.28904046e-01, 5.88014943e-01,
00977   2.06199101e-01, 3.33942314e-01, 5.77272331e-01, 2.02269779e-01,
00978   2.49881715e-01, 2.47466358e+00, 3.28415139e-01, 1.13293282e+00,
00979   1.13727027e+00, 2.58543521e-01, 3.23032809e-01, 3.48766905e-01,
00980   3.16415957e-01, 4.49399804e-01, 8.04058132e-01, 5.31607752e+00,
00981   2.99756311e-01, 7.50000000e-01, 4.04621372e-01, 3.39550748e-01,
00982   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 1.67659508e+00},
00983  {0.00000000e+00, 2.83637106e-01, 1.42810925e-01, 2.50594014e-01,
00984   1.15609648e-01, 2.02669731e-01, 9.82154073e-01, 2.34021877e-01,
00985   3.84396440e-01, 2.84494454e-01, 1.74946435e-01, 3.72830750e-01,
00986   4.92730381e-01, 1.78320001e-01, 1.74477792e-01, 3.51106744e-01,
00987   2.48889195e-01, 2.30316670e-01, 2.27083637e-01, 2.99756311e-01,
00988   4.26750567e+01, 7.50000000e-01, 1.77446682e+00, 2.58826370e-01,
00989   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 3.37037347e-01},
00990  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00991   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00992   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00993   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00994   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00995   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
00996   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 7.50000000e-01},
00997  {0.00000000e+00, 3.70274337e-01, 2.77062678e-01, 2.92512133e-01,
00998   2.13739536e-01, 2.73296982e-01, 2.77172979e+00, 1.88904853e-01,
00999   1.62620965e+00, 4.78737209e-01, 3.46172886e-01, 5.08794972e-01,
01000   4.80316866e-01, 3.59725936e-01, 2.13074361e-01, 4.01714365e-01,
01001   3.62347797e-01, 4.11583504e-01, 4.20544390e-01, 4.04621372e-01,
01002   1.77446682e+00, 7.50000000e-01, 1.36090374e+01, 3.21879801e-01,
01003   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 4.96615724e-01},
01004  {0.00000000e+00, 6.55892238e-01, 1.06526643e+00, 1.82991170e-01,
01005   1.26113669e+00, 5.61081481e+00, 2.33605433e-01, 3.59819671e-01,
01006   9.52331980e-01, 2.53644956e-01, 1.23156378e+00, 2.89246563e-01,
01007   5.46178209e-01, 8.09573592e-01, 5.12969199e-01, 4.91663315e+00,
01008   9.31246918e-01, 7.70078852e-01, 6.35332398e-01, 3.39550748e-01,
01009   2.58826370e-01, 7.50000000e-01, 3.21879801e-01, 5.34819225e+00,
01010   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 2.74820979e-01},
01011  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01012   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01013   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01014   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01015   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01016   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01017   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 7.50000000e-01},
01018  {0.00000000e+00, 1.20000000e-01, 1.20000000e-01, 1.20000000e-01,
01019   1.20000000e-01, 1.20000000e-01, 1.20000000e-01, 1.20000000e-01,
01020   1.20000000e-01, 1.20000000e-01, 1.20000000e-01, 1.20000000e-01,
01021   1.20000000e-01, 1.20000000e-01, 1.20000000e-01, 1.20000000e-01,
01022   1.20000000e-01, 1.20000000e-01, 1.20000000e-01, 1.20000000e-01,
01023   1.20000000e-01, 1.20000000e-01, 1.20000000e-01, 1.20000000e-01,
01024   1.20000000e-01, 1.33300000e+00, 1.20000000e-01, 1.20000000e-01},
01025  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01026   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01027   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01028   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01029   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01030   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01031   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 7.50000000e-01},
01032  {0.00000000e+00, 4.58271706e-01, 1.95138263e-01, 4.63931905e-01,
01033   1.71274897e-01, 2.37333866e-01, 9.38207661e-01, 1.70365676e-01,
01034   2.66176152e-01, 3.22503669e+00, 3.04624249e-01, 3.63712766e+00,
01035   1.83504401e+00, 2.26289963e-01, 2.67560235e-01, 3.36422330e-01,
01036   3.03390753e-01, 3.36254561e-01, 5.53180238e-01, 1.67659508e+00,
01037   3.37037347e-01, 7.50000000e-01, 4.96615724e-01, 2.74820979e-01,
01038   7.50000000e-01, 1.20000000e-01, 7.50000000e-01, 3.47015056e+00}};
01039 
01040 
01041 /** Underlying frequency ratios for PAM30 */
01042 static const double PAM30_FREQRATIOS[BLASTAA_SIZE][BLASTAA_SIZE] =
01043 {{0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01044   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01045   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01046   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01047   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01048   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01049   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00},
01050  {0.00000000e+00, 7.78912912e+00, 3.02026381e-01, 1.07971742e-01,
01051   3.16807704e-01, 4.53014491e-01, 5.67768414e-02, 5.75744366e-01,
01052   8.33329143e-02, 1.98631007e-01, 9.54324770e-02, 1.15281887e-01,
01053   1.89338526e-01, 2.84890839e-01, 5.93402017e-01, 2.35344432e-01,
01054   9.10275603e-02, 8.75340369e-01, 8.27084092e-01, 4.77504036e-01,
01055   9.76867708e-03, 7.50000000e-01, 6.99222384e-02, 3.58158006e-01,
01056   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 1.40431646e-01},
01057  {0.00000000e+00, 3.02026381e-01, 8.11766307e+00, 1.52757717e-02,
01058   8.45582330e+00, 1.47233532e+00, 2.69459344e-02, 3.37867839e-01,
01059   6.63755159e-01, 1.25827363e-01, 4.40914175e-01, 4.89221062e-02,
01060   3.39137767e-02, 7.72564409e+00, 1.02509984e-01, 3.67813095e-01,
01061   8.23817770e-02, 6.03773710e-01, 3.53305100e-01, 6.71234492e-02,
01062   3.23783774e-02, 7.50000000e-01, 1.13742904e-01, 9.91005473e-01,
01063   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 7.21274943e-02},
01064  {0.00000000e+00, 1.07971742e-01, 1.52757717e-02, 2.75882699e+01,
01065   7.71413760e-03, 7.86819951e-03, 1.16056875e-02, 4.15734061e-02,
01066   7.76695875e-02, 1.19064797e-01, 7.78302876e-03, 6.02160155e-03,
01067   9.46008155e-03, 2.40417467e-02, 6.32617140e-02, 8.13944094e-03,
01068   6.80179741e-02, 3.79110970e-01, 6.77518036e-02, 1.32369559e-01,
01069   4.67559620e-03, 7.50000000e-01, 2.57579768e-01, 7.98640138e-03,
01070   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 4.01312493e-02},
01071  {0.00000000e+00, 3.16807704e-01, 8.45582330e+00, 7.71413760e-03,
01072   1.42349183e+01, 2.34246282e+00, 6.53544516e-03, 3.26331184e-01,
01073   2.71287596e-01, 7.98669838e-02, 2.19798242e-01, 1.38483017e-02,
01074   2.29035955e-02, 1.75629226e+00, 6.80928461e-02, 4.27289142e-01,
01075   2.95026156e-02, 2.86012439e-01, 1.99709663e-01, 6.47860871e-02,
01076   5.42804139e-03, 7.50000000e-01, 1.97046510e-02, 1.50786644e+00,
01077   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 3.37687752e-02},
01078  {0.00000000e+00, 4.53014491e-01, 1.47233532e+00, 7.86819951e-03,
01079   2.34246282e+00, 1.36624533e+01, 7.86638136e-03, 2.31589040e-01,
01080   1.81505594e-01, 1.49736909e-01, 2.26119978e-01, 4.27891596e-02,
01081   9.24578171e-02, 4.63622671e-01, 1.53529752e-01, 1.50713628e+00,
01082   4.28627549e-02, 2.25474962e-01, 1.30340902e-01, 1.09854687e-01,
01083   3.23568839e-03, 7.50000000e-01, 5.65446816e-02, 8.36539662e+00,
01084   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 7.50595678e-02},
01085  {0.00000000e+00, 5.67768414e-02, 2.69459344e-02, 1.16056875e-02,
01086   6.53544516e-03, 7.86638136e-03, 2.14068164e+01, 4.44753676e-02,
01087   1.31584637e-01, 4.73011553e-01, 8.55473177e-03, 4.15676862e-01,
01088   2.49857403e-01, 5.06072009e-02, 3.56716332e-02, 1.12390799e-02,
01089   4.18628794e-02, 1.13897780e-01, 5.14073961e-02, 6.66400959e-02,
01090   2.13219283e-01, 7.50000000e-01, 1.78617980e+00, 9.33613946e-03,
01091   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 4.32977029e-01},
01092  {0.00000000e+00, 5.75744366e-01, 3.37867839e-01, 4.15734061e-02,
01093   3.26331184e-01, 2.31589040e-01, 4.44753676e-02, 9.31368857e+00,
01094   4.78871557e-02, 2.41395424e-02, 8.59403011e-02, 2.78096704e-02,
01095   5.67940501e-02, 3.51241937e-01, 1.21951553e-01, 9.44408638e-02,
01096   3.97493058e-02, 5.52895766e-01, 1.35075690e-01, 1.48994667e-01,
01097   5.68401675e-03, 7.50000000e-01, 9.25861867e-03, 1.71822465e-01,
01098   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 2.67022462e-02},
01099  {0.00000000e+00, 8.33329143e-02, 6.63755159e-01, 7.76695875e-02,
01100   2.71287596e-01, 1.81505594e-01, 1.31584637e-01, 4.78871557e-02,
01101   2.29276353e+01, 4.36863126e-02, 1.19631443e-01, 1.23251186e-01,
01102   2.78547216e-02, 1.11873100e+00, 2.47982049e-01, 1.35964891e+00,
01103   5.86952720e-01, 1.31501535e-01, 8.61653901e-02, 1.14978024e-01,
01104   8.12035191e-02, 7.50000000e-01, 3.23746871e-01, 6.94918113e-01,
01105   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 9.92432853e-02},
01106  {0.00000000e+00, 1.98631007e-01, 1.25827363e-01, 1.19064797e-01,
01107   7.98669838e-02, 1.49736909e-01, 4.73011553e-01, 2.41395424e-02,
01108   4.36863126e-02, 1.86346064e+01, 1.27210180e-01, 6.43409762e-01,
01109   7.92524183e-01, 1.79107849e-01, 5.32543187e-02, 7.03383168e-02,
01110   1.58533228e-01, 9.68805230e-02, 4.44355269e-01, 1.93788392e+00,
01111   9.23811792e-03, 7.50000000e-01, 1.18573178e-01, 1.15136508e-01,
01112   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 6.07207247e+00},
01113  {0.00000000e+00, 9.54324770e-02, 4.40914175e-01, 7.78302876e-03,
01114   2.19798242e-01, 2.26119978e-01, 8.55473177e-03, 8.59403011e-02,
01115   1.19631443e-01, 1.27210180e-01, 9.98780825e+00, 6.07412260e-02,
01116   5.62560724e-01, 6.97247226e-01, 1.06485246e-01, 3.84266618e-01,
01117   1.11121735e+00, 2.59857530e-01, 3.36316040e-01, 4.62631009e-02,
01118   1.75142268e-02, 7.50000000e-01, 4.16645387e-02, 2.95037286e-01,
01119   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 8.07975645e-02},
01120  {0.00000000e+00, 1.15281887e-01, 4.89221062e-02, 6.02160155e-03,
01121   1.38483017e-02, 4.27891596e-02, 4.15676862e-01, 2.78096704e-02,
01122   1.23251186e-01, 6.43409762e-01, 6.07412260e-02, 1.00194105e+01,
01123   1.24218990e+00, 8.95821132e-02, 9.04970355e-02, 1.84988987e-01,
01124   5.31753716e-02, 5.83025512e-02, 1.02884887e-01, 4.62744892e-01,
01125   1.27405990e-01, 7.50000000e-01, 9.50388211e-02, 1.04757148e-01,
01126   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 7.19029657e+00},
01127  {0.00000000e+00, 1.89338526e-01, 3.39137767e-02, 9.46008155e-03,
01128   2.29035955e-02, 9.24578171e-02, 2.49857403e-01, 5.67940501e-02,
01129   2.78547216e-02, 7.92524183e-01, 5.62560724e-01, 1.24218990e+00,
01130   4.65953079e+01, 4.66775487e-02, 6.48026667e-02, 2.71732304e-01,
01131   2.43002286e-01, 1.60899996e-01, 2.62669188e-01, 6.30878126e-01,
01132   1.29243603e-02, 7.50000000e-01, 2.12719960e-02, 1.70582240e-01,
01133   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 1.10650779e+00},
01134  {0.00000000e+00, 2.84890839e-01, 7.72564409e+00, 2.40417467e-02,
01135   1.75629226e+00, 4.63622671e-01, 5.06072009e-02, 3.51241937e-01,
01136   1.11873100e+00, 1.79107849e-01, 6.97247226e-01, 8.95821132e-02,
01137   4.66775487e-02, 1.46457342e+01, 1.42408737e-01, 2.98864303e-01,
01138   1.43682999e-01, 9.72144796e-01, 5.31363673e-01, 6.98330827e-02,
01139   6.36210916e-02, 7.50000000e-01, 2.22758622e-01, 3.91824098e-01,
01140   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 1.16595604e-01},
01141  {0.00000000e+00, 5.93402017e-01, 1.02509984e-01, 6.32617140e-02,
01142   6.80928461e-02, 1.53529752e-01, 3.56716332e-02, 1.21951553e-01,
01143   2.47982049e-01, 5.32543187e-02, 1.06485246e-01, 9.04970355e-02,
01144   6.48026667e-02, 1.42408737e-01, 1.58088136e+01, 3.76066261e-01,
01145   2.69813309e-01, 5.70573606e-01, 2.40194503e-01, 1.40453450e-01,
01146   9.02230244e-03, 7.50000000e-01, 9.80486654e-03, 2.50506944e-01,
01147   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 7.92594202e-02},
01148  {0.00000000e+00, 2.35344432e-01, 3.67813095e-01, 8.13944094e-03,
01149   4.27289142e-01, 1.50713628e+00, 1.12390799e-02, 9.44408638e-02,
01150   1.35964891e+00, 7.03383168e-02, 3.84266618e-01, 1.84988987e-01,
01151   2.71732304e-01, 2.98864303e-01, 3.76066261e-01, 1.81380436e+01,
01152   5.84920778e-01, 1.67743101e-01, 1.50331260e-01, 1.02742037e-01,
01153   1.20726953e-02, 7.50000000e-01, 1.69239569e-02, 8.75457039e+00,
01154   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 1.50394300e-01},
01155  {0.00000000e+00, 9.10275603e-02, 8.23817770e-02, 6.80179741e-02,
01156   2.95026156e-02, 4.28627549e-02, 4.18628794e-02, 3.97493058e-02,
01157   5.86952720e-01, 1.58533228e-01, 1.11121735e+00, 5.31753716e-02,
01158   2.43002286e-01, 1.43682999e-01, 2.69813309e-01, 5.84920778e-01,
01159   1.89240175e+01, 3.54610075e-01, 1.06409795e-01, 7.42726505e-02,
01160   5.17051285e-01, 7.50000000e-01, 3.01584225e-02, 2.79081365e-01,
01161   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 8.49660454e-02},
01162  {0.00000000e+00, 8.75340369e-01, 6.03773710e-01, 3.79110970e-01,
01163   2.86012439e-01, 2.25474962e-01, 1.13897780e-01, 5.52895766e-01,
01164   1.31501535e-01, 9.68805230e-02, 2.59857530e-01, 5.83025512e-02,
01165   1.60899996e-01, 9.72144796e-01, 5.70573606e-01, 1.67743101e-01,
01166   3.54610075e-01, 9.02800848e+00, 1.14463515e+00, 1.17807053e-01,
01167   1.79210510e-01, 7.50000000e-01, 9.65415148e-02, 2.00316511e-01,
01168   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 6.99430663e-02},
01169  {0.00000000e+00, 8.27084092e-01, 3.53305100e-01, 6.77518036e-02,
01170   1.99709663e-01, 1.30340902e-01, 5.14073961e-02, 1.35075690e-01,
01171   8.61653901e-02, 4.44355269e-01, 3.36316040e-01, 1.02884887e-01,
01172   2.62669188e-01, 5.31363673e-01, 2.40194503e-01, 1.50331260e-01,
01173   1.06409795e-01, 1.14463515e+00, 1.16950751e+01, 3.90871695e-01,
01174   1.25703039e-02, 7.50000000e-01, 1.11995399e-01, 1.39052321e-01,
01175   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 2.05920141e-01},
01176  {0.00000000e+00, 4.77504036e-01, 6.71234492e-02, 1.32369559e-01,
01177   6.47860871e-02, 1.09854687e-01, 6.66400959e-02, 1.48994667e-01,
01178   1.14978024e-01, 1.93788392e+00, 4.62631009e-02, 4.62744892e-01,
01179   6.30878126e-01, 6.98330827e-02, 1.40453450e-01, 1.02742037e-01,
01180   7.42726505e-02, 1.17807053e-01, 3.90871695e-01, 1.16090589e+01,
01181   5.05672115e-03, 7.50000000e-01, 8.04763342e-02, 1.06755129e-01,
01182   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 9.07853260e-01},
01183  {0.00000000e+00, 9.76867708e-03, 3.23783774e-02, 4.67559620e-03,
01184   5.42804139e-03, 3.23568839e-03, 2.13219283e-01, 5.68401675e-03,
01185   8.12035191e-02, 9.23811792e-03, 1.75142268e-02, 1.27405990e-01,
01186   1.29243603e-02, 6.36210916e-02, 9.02230244e-03, 1.20726953e-02,
01187   5.17051285e-01, 1.79210510e-01, 1.25703039e-02, 5.05672115e-03,
01188   8.86903633e+01, 7.50000000e-01, 1.73378233e-01, 7.08668846e-03,
01189   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 9.17500230e-02},
01190  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01191   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01192   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01193   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01194   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01195   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01196   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 7.50000000e-01},
01197  {0.00000000e+00, 6.99222384e-02, 1.13742904e-01, 2.57579768e-01,
01198   1.97046510e-02, 5.65446816e-02, 1.78617980e+00, 9.25861867e-03,
01199   3.23746871e-01, 1.18573178e-01, 4.16645387e-02, 9.50388211e-02,
01200   2.12719960e-02, 2.22758622e-01, 9.80486654e-03, 1.69239569e-02,
01201   3.01584225e-02, 9.65415148e-02, 1.11995399e-01, 8.04763342e-02,
01202   1.73378233e-01, 7.50000000e-01, 2.84454162e+01, 3.92787209e-02,
01203   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 1.02140077e-01},
01204  {0.00000000e+00, 3.58158006e-01, 9.91005473e-01, 7.98640138e-03,
01205   1.50786644e+00, 8.36539662e+00, 9.33613946e-03, 1.71822465e-01,
01206   6.94918113e-01, 1.15136508e-01, 2.95037286e-01, 1.04757148e-01,
01207   1.70582240e-01, 3.91824098e-01, 2.50506944e-01, 8.75457039e+00,
01208   2.79081365e-01, 2.00316511e-01, 1.39052321e-01, 1.06755129e-01,
01209   7.08668846e-03, 7.50000000e-01, 3.92787209e-02, 8.53499117e+00,
01210   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 1.07889016e-01},
01211  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01212   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01213   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01214   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01215   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01216   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01217   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 7.50000000e-01},
01218  {0.00000000e+00, 3.00000000e-03, 3.00000000e-03, 3.00000000e-03,
01219   3.00000000e-03, 3.00000000e-03, 3.00000000e-03, 3.00000000e-03,
01220   3.00000000e-03, 3.00000000e-03, 3.00000000e-03, 3.00000000e-03,
01221   3.00000000e-03, 3.00000000e-03, 3.00000000e-03, 3.00000000e-03,
01222   3.00000000e-03, 3.00000000e-03, 3.00000000e-03, 3.00000000e-03,
01223   3.00000000e-03, 3.00000000e-03, 3.00000000e-03, 3.00000000e-03,
01224   3.00000000e-03, 1.33300000e+00, 3.00000000e-03, 3.00000000e-03},
01225  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01226   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01227   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01228   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01229   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01230   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01231   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 7.50000000e-01},
01232  {0.00000000e+00, 1.40431646e-01, 7.21274943e-02, 4.01312493e-02,
01233   3.37687752e-02, 7.50595678e-02, 4.32977029e-01, 2.67022462e-02,
01234   9.92432853e-02, 6.07207247e+00, 8.07975645e-02, 7.19029657e+00,
01235   1.10650779e+00, 1.16595604e-01, 7.92594202e-02, 1.50394300e-01,
01236   8.49660454e-02, 6.99430663e-02, 2.05920141e-01, 9.07853260e-01,
01237   9.17500230e-02, 7.50000000e-01, 1.02140077e-01, 1.07889016e-01,
01238   7.50000000e-01, 3.00000000e-03, 7.50000000e-01, 6.85288369e+00}};
01239 
01240 
01241 /** Underlying frequency ratios for PAM70 */
01242 static const double PAM70_FREQRATIOS[BLASTAA_SIZE][BLASTAA_SIZE] =
01243 {{0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01244   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01245   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01246   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01247   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01248   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01249   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00},
01250  {0.00000000e+00, 4.89972946e+00, 6.04638890e-01, 2.42067963e-01,
01251   6.18433760e-01, 7.71213936e-01, 1.34833512e-01, 1.01498720e+00,
01252   2.21390981e-01, 4.34566961e-01, 2.49319770e-01, 2.49736666e-01,
01253   3.75829845e-01, 5.88646912e-01, 1.03045017e+00, 4.65602795e-01,
01254   2.26934456e-01, 1.34964157e+00, 1.32707297e+00, 8.08640731e-01,
01255   4.32618091e-02, 7.50000000e-01, 1.54222102e-01, 6.38034395e-01,
01256   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 3.05507349e-01},
01257  {0.00000000e+00, 6.04638890e-01, 5.42142610e+00, 6.60540784e-02,
01258   5.88929014e+00, 2.24885858e+00, 7.88958522e-02, 6.48829213e-01,
01259   1.09845328e+00, 2.52789787e-01, 7.77906911e-01, 1.19715714e-01,
01260   1.39730820e-01, 4.87904539e+00, 2.73736473e-01, 7.90138593e-01,
01261   2.53425041e-01, 9.54703234e-01, 6.53688648e-01, 1.85063408e-01,
01262   7.80441148e-02, 7.50000000e-01, 2.23329473e-01, 1.61317606e+00,
01263   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 1.59869478e-01},
01264  {0.00000000e+00, 2.42067963e-01, 6.60540784e-02, 2.48333286e+01,
01265   3.97130183e-02, 3.87120726e-02, 5.48382532e-02, 1.15679023e-01,
01266   1.64834856e-01, 2.46442788e-01, 3.83065039e-02, 3.01944614e-02,
01267   4.42379868e-02, 9.65904773e-02, 1.58823055e-01, 3.93861754e-02,
01268   1.51302811e-01, 6.65193229e-01, 1.86417892e-01, 2.74442219e-01,
01269   2.22251459e-02, 7.50000000e-01, 5.23320532e-01, 3.90058338e-02,
01270   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 9.54452197e-02},
01271  {0.00000000e+00, 6.18433760e-01, 5.88929014e+00, 3.97130183e-02,
01272   8.89965209e+00, 3.35659301e+00, 3.36340414e-02, 6.39387415e-01,
01273   5.99746161e-01, 1.93031482e-01, 4.83846284e-01, 6.35580693e-02,
01274   1.03502951e-01, 2.39946804e+00, 2.12686642e-01, 9.22524100e-01,
01275   1.38560979e-01, 5.99713481e-01, 4.42110174e-01, 1.72922381e-01,
01276   2.64171458e-02, 7.50000000e-01, 7.98817496e-02, 2.29587193e+00,
01277   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 1.02625370e-01},
01278  {0.00000000e+00, 7.71213936e-01, 2.24885858e+00, 3.87120726e-02,
01279   3.35659301e+00, 8.65385421e+00, 3.82398528e-02, 4.91841782e-01,
01280   4.80150693e-01, 2.83623924e-01, 4.66181910e-01, 1.17487568e-01,
01281   2.12426533e-01, 9.64695360e-01, 3.47480663e-01, 2.25815498e+00,
01282   1.78914910e-01, 4.78627630e-01, 3.38114944e-01, 2.46972907e-01,
01283   1.89756038e-02, 7.50000000e-01, 1.19141830e-01, 5.86672974e+00,
01284   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 1.67617543e-01},
01285  {0.00000000e+00, 1.34833512e-01, 7.88958522e-02, 5.48382532e-02,
01286   3.36340414e-02, 3.82398528e-02, 1.74546228e+01, 1.00136016e-01,
01287   2.76577280e-01, 8.45971180e-01, 4.12894272e-02, 8.23804865e-01,
01288   5.08442478e-01, 1.31366508e-01, 8.91727264e-02, 5.25046736e-02,
01289   9.93639027e-02, 2.15603624e-01, 1.37600314e-01, 2.07856659e-01,
01290   4.52242030e-01, 7.50000000e-01, 3.37849562e+00, 4.44561913e-02,
01291   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 8.30493328e-01},
01292  {0.00000000e+00, 1.01498720e+00, 6.48829213e-01, 1.15679023e-01,
01293   6.39387415e-01, 4.91841782e-01, 1.00136016e-01, 7.30864335e+00,
01294   1.45138751e-01, 1.07004308e-01, 2.09861286e-01, 8.09786598e-02,
01295   1.44276056e-01, 6.59774806e-01, 3.08399509e-01, 2.37177521e-01,
01296   1.22086776e-01, 9.64187863e-01, 3.70424893e-01, 3.12986176e-01,
01297   2.68996967e-02, 7.50000000e-01, 4.37757319e-02, 3.80863925e-01,
01298   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 8.88316375e-02},
01299  {0.00000000e+00, 2.21390981e-01, 1.09845328e+00, 1.64834856e-01,
01300   5.99746161e-01, 4.80150693e-01, 2.76577280e-01, 1.45138751e-01,
01301   1.64223829e+01, 1.39752446e-01, 3.35085062e-01, 2.59072609e-01,
01302   1.22395235e-01, 1.67658945e+00, 4.92867985e-01, 2.18832010e+00,
01303   1.05779530e+00, 3.26721114e-01, 2.30266854e-01, 2.33270842e-01,
01304   1.86063506e-01, 7.50000000e-01, 6.11386658e-01, 1.22453853e+00,
01305   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 2.23068949e-01},
01306  {0.00000000e+00, 4.34566961e-01, 2.52789787e-01, 2.46442788e-01,
01307   1.93031482e-01, 2.83623924e-01, 8.45971180e-01, 1.07004308e-01,
01308   1.39752446e-01, 1.17505537e+01, 2.66278255e-01, 1.19239531e+00,
01309   1.36908981e+00, 3.22065793e-01, 1.59577365e-01, 1.89299534e-01,
01310   3.01479599e-01, 2.53646367e-01, 7.61111058e-01, 3.00374358e+00,
01311   4.36969076e-02, 7.50000000e-01, 2.80489781e-01, 2.42519143e-01,
01312   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 4.37821344e+00},
01313  {0.00000000e+00, 2.49319770e-01, 7.77906911e-01, 3.83065039e-02,
01314   4.83846284e-01, 4.66181910e-01, 4.12894272e-02, 2.09861286e-01,
01315   3.35085062e-01, 2.66278255e-01, 7.61026217e+00, 1.52754534e-01,
01316   9.47937549e-01, 1.11880255e+00, 2.56118662e-01, 7.21669881e-01,
01317   1.93666556e+00, 5.20459614e-01, 6.20196625e-01, 1.38845936e-01,
01318   7.91911207e-02, 7.50000000e-01, 1.00771644e-01, 5.77518724e-01,
01319   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 1.87009175e-01},
01320  {0.00000000e+00, 2.49736666e-01, 1.19715714e-01, 3.01944614e-02,
01321   6.35580693e-02, 1.17487568e-01, 8.23804865e-01, 8.09786598e-02,
01322   2.59072609e-01, 1.19239531e+00, 1.52754534e-01, 8.22843955e+00,
01323   2.12939550e+00, 1.84817584e-01, 1.98778178e-01, 3.50784854e-01,
01324   1.37359422e-01, 1.48574310e-01, 2.40326213e-01, 9.08401895e-01,
01325   2.67168548e-01, 7.50000000e-01, 2.38980900e-01, 2.19154102e-01,
01326   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 6.10538395e+00},
01327  {0.00000000e+00, 3.75829845e-01, 1.39730820e-01, 4.42379868e-02,
01328   1.03502951e-01, 2.12426533e-01, 5.08442478e-01, 1.44276056e-01,
01329   1.22395235e-01, 1.36908981e+00, 9.47937549e-01, 2.12939550e+00,
01330   2.85861616e+01, 1.81728699e-01, 1.75926195e-01, 4.86044449e-01,
01331   4.88080973e-01, 3.18976045e-01, 4.97701201e-01, 1.13284160e+00,
01332   5.97810639e-02, 7.50000000e-01, 9.73038916e-02, 3.31664034e-01,
01333   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 1.89998090e+00},
01334  {0.00000000e+00, 5.88646912e-01, 4.87904539e+00, 9.65904773e-02,
01335   2.39946804e+00, 9.64695360e-01, 1.31366508e-01, 6.59774806e-01,
01336   1.67658945e+00, 3.22065793e-01, 1.11880255e+00, 1.84817584e-01,
01337   1.81728699e-01, 7.75354485e+00, 3.44509706e-01, 6.36668056e-01,
01338   3.86583495e-01, 1.36623218e+00, 8.98965212e-01, 1.99138136e-01,
01339   1.37893708e-01, 7.50000000e-01, 3.89624106e-01, 8.21747280e-01,
01340   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 2.26230851e-01},
01341  {0.00000000e+00, 1.03045017e+00, 2.73736473e-01, 1.58823055e-01,
01342   2.12686642e-01, 3.47480663e-01, 8.91727264e-02, 3.08399509e-01,
01343   4.92867985e-01, 1.59577365e-01, 2.56118662e-01, 1.98778178e-01,
01344   1.75926195e-01, 3.44509706e-01, 1.18714088e+01, 6.84263791e-01,
01345   5.26778639e-01, 9.79291808e-01, 5.30644206e-01, 3.07279290e-01,
01346   4.18182164e-02, 7.50000000e-01, 4.66910129e-02, 4.94244365e-01,
01347   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 1.86949727e-01},
01348  {0.00000000e+00, 4.65602795e-01, 7.90138593e-01, 3.93861754e-02,
01349   9.22524100e-01, 2.25815498e+00, 5.25046736e-02, 2.37177521e-01,
01350   2.18832010e+00, 1.89299534e-01, 7.21669881e-01, 3.50784854e-01,
01351   4.86044449e-01, 6.36668056e-01, 6.84263791e-01, 1.14706864e+01,
01352   1.02361055e+00, 3.73519396e-01, 3.29322200e-01, 2.32053434e-01,
01353   5.49721446e-02, 7.50000000e-01, 7.38645866e-02, 6.27280154e+00,
01354   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 3.02058283e-01},
01355  {0.00000000e+00, 2.26934456e-01, 2.53425041e-01, 1.51302811e-01,
01356   1.38560979e-01, 1.78914910e-01, 9.93639027e-02, 1.22086776e-01,
01357   1.05779530e+00, 3.01479599e-01, 1.93666556e+00, 1.37359422e-01,
01358   4.88080973e-01, 3.86583495e-01, 5.26778639e-01, 1.02361055e+00,
01359   1.36584013e+01, 6.10010848e-01, 2.83658630e-01, 1.75829089e-01,
01360   9.90780192e-01, 7.50000000e-01, 8.59463892e-02, 5.47017256e-01,
01361   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 1.86881035e-01},
01362  {0.00000000e+00, 1.34964157e+00, 9.54703234e-01, 6.65193229e-01,
01363   5.99713481e-01, 4.78627630e-01, 2.15603624e-01, 9.64187863e-01,
01364   3.26721114e-01, 2.53646367e-01, 5.20459614e-01, 1.48574310e-01,
01365   3.18976045e-01, 1.36623218e+00, 9.79291808e-01, 3.73519396e-01,
01366   6.10010848e-01, 5.20445832e+00, 1.69490837e+00, 3.03324606e-01,
01367   3.23868004e-01, 7.50000000e-01, 2.08076540e-01, 4.32823454e-01,
01368   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 1.80278747e-01},
01369  {0.00000000e+00, 1.32707297e+00, 6.53688648e-01, 1.86417892e-01,
01370   4.42110174e-01, 3.38114944e-01, 1.37600314e-01, 3.70424893e-01,
01371   2.30266854e-01, 7.61111058e-01, 6.20196625e-01, 2.40326213e-01,
01372   4.97701201e-01, 8.98965212e-01, 5.30644206e-01, 3.29322200e-01,
01373   2.83658630e-01, 1.69490837e+00, 7.33707214e+00, 7.18561720e-01,
01374   5.45397612e-02, 7.50000000e-01, 2.27833757e-01, 3.34283233e-01,
01375   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 3.97467804e-01},
01376  {0.00000000e+00, 8.08640731e-01, 1.85063408e-01, 2.74442219e-01,
01377   1.72922381e-01, 2.46972907e-01, 2.07856659e-01, 3.12986176e-01,
01378   2.33270842e-01, 3.00374358e+00, 1.38845936e-01, 9.08401895e-01,
01379   1.13284160e+00, 1.99138136e-01, 3.07279290e-01, 2.32053434e-01,
01380   1.75829089e-01, 3.03324606e-01, 7.18561720e-01, 8.21110545e+00,
01381   2.66588959e-02, 7.50000000e-01, 1.80843519e-01, 2.40471284e-01,
01382   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 1.54065018e+00},
01383  {0.00000000e+00, 4.32618091e-02, 7.80441148e-02, 2.22251459e-02,
01384   2.64171458e-02, 1.89756038e-02, 4.52242030e-01, 2.68996967e-02,
01385   1.86063506e-01, 4.36969076e-02, 7.91911207e-02, 2.67168548e-01,
01386   5.97810639e-02, 1.37893708e-01, 4.18182164e-02, 5.49721446e-02,
01387   9.90780192e-01, 3.23868004e-01, 5.45397612e-02, 2.66588959e-02,
01388   8.06167129e+01, 7.50000000e-01, 3.76692625e-01, 3.46622138e-02,
01389   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 1.99738227e-01},
01390  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01391   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01392   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01393   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01394   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01395   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01396   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 7.50000000e-01},
01397  {0.00000000e+00, 1.54222102e-01, 2.23329473e-01, 5.23320532e-01,
01398   7.98817496e-02, 1.19141830e-01, 3.37849562e+00, 4.37757319e-02,
01399   6.11386658e-01, 2.80489781e-01, 1.00771644e-01, 2.38980900e-01,
01400   9.73038916e-02, 3.89624106e-01, 4.66910129e-02, 7.38645866e-02,
01401   8.59463892e-02, 2.08076540e-01, 2.27833757e-01, 1.80843519e-01,
01402   3.76692625e-01, 7.50000000e-01, 2.31438270e+01, 9.94108657e-02,
01403   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 2.51505787e-01},
01404  {0.00000000e+00, 6.38034395e-01, 1.61317606e+00, 3.90058338e-02,
01405   2.29587193e+00, 5.86672974e+00, 4.44561913e-02, 3.80863925e-01,
01406   1.22453853e+00, 2.42519143e-01, 5.77518724e-01, 2.19154102e-01,
01407   3.31664034e-01, 8.21747280e-01, 4.94244365e-01, 6.27280154e+00,
01408   5.47017256e-01, 4.32823454e-01, 3.34283233e-01, 2.40471284e-01,
01409   3.46622138e-02, 7.50000000e-01, 9.94108657e-02, 6.04368813e+00,
01410   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 2.26204268e-01},
01411  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01412   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01413   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01414   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01415   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01416   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01417   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 7.50000000e-01},
01418  {0.00000000e+00, 2.00000000e-02, 2.00000000e-02, 2.00000000e-02,
01419   2.00000000e-02, 2.00000000e-02, 2.00000000e-02, 2.00000000e-02,
01420   2.00000000e-02, 2.00000000e-02, 2.00000000e-02, 2.00000000e-02,
01421   2.00000000e-02, 2.00000000e-02, 2.00000000e-02, 2.00000000e-02,
01422   2.00000000e-02, 2.00000000e-02, 2.00000000e-02, 2.00000000e-02,
01423   2.00000000e-02, 2.00000000e-02, 2.00000000e-02, 2.00000000e-02,
01424   2.00000000e-02, 1.33300000e+00, 2.00000000e-02, 2.00000000e-02},
01425  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01426   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01427   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01428   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01429   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01430   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01431   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 7.50000000e-01},
01432  {0.00000000e+00, 3.05507349e-01, 1.59869478e-01, 9.54452197e-02,
01433   1.02625370e-01, 1.67617543e-01, 8.30493328e-01, 8.88316375e-02,
01434   2.23068949e-01, 4.37821344e+00, 1.87009175e-01, 6.10538395e+00,
01435   1.89998090e+00, 2.26230851e-01, 1.86949727e-01, 3.02058283e-01,
01436   1.86881035e-01, 1.80278747e-01, 3.97467804e-01, 1.54065018e+00,
01437   1.99738227e-01, 7.50000000e-01, 2.51505787e-01, 2.26204268e-01,
01438   7.50000000e-01, 2.00000000e-02, 7.50000000e-01, 5.58422761e+00}};
01439 
01440 
01441 /** Underlying frequency ratios for PAM250 */
01442 static const double PAM250_FREQRATIOS[BLASTAA_SIZE][BLASTAA_SIZE] =
01443 {{0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01444   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01445   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01446   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01447   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01448   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00,
01449   0.00000000e+00, 0.00000000e+00, 0.00000000e+00, 0.00000000e+00},
01450  {0.00000000e+00, 1.51578006e+00, 1.05606466e+00, 6.26687137e-01,
01451   1.07002228e+00, 1.07474947e+00, 4.46290560e-01, 1.33923306e+00,
01452   7.32178470e-01, 8.88728816e-01, 7.66227814e-01, 6.46341735e-01,
01453   7.70359541e-01, 1.03988401e+00, 1.29408826e+00, 9.03456780e-01,
01454   7.00798809e-01, 1.28966428e+00, 1.31725380e+00, 1.04499203e+00,
01455   2.63609841e-01, 7.50000000e-01, 4.49686798e-01, 1.00010336e+00,
01456   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 7.19479599e-01},
01457  {0.00000000e+00, 1.05606466e+00, 1.84257846e+00, 3.65113184e-01,
01458   2.05195422e+00, 1.82470118e+00, 3.54071966e-01, 1.11918465e+00,
01459   1.29683470e+00, 6.16970770e-01, 1.13010166e+00, 4.52559218e-01,
01460   6.04775077e-01, 1.59985542e+00, 8.46142888e-01, 1.33890747e+00,
01461   8.61808201e-01, 1.11706882e+00, 1.03197349e+00, 6.37811920e-01,
01462   2.96793416e-01, 7.50000000e-01, 4.85608019e-01, 1.61300149e+00,
01463   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 5.02168751e-01},
01464  {0.00000000e+00, 6.26687137e-01, 3.65113184e-01, 1.56285624e+01,
01465   3.06772262e-01, 2.94964746e-01, 3.70976416e-01, 4.59297624e-01,
01466   4.51836855e-01, 5.87603719e-01, 2.86099293e-01, 2.47791243e-01,
01467   2.99408166e-01, 4.32746060e-01, 5.27421501e-01, 2.89534285e-01,
01468   4.30504374e-01, 9.89678273e-01, 6.01385571e-01, 6.38902701e-01,
01469   1.68818010e-01, 7.50000000e-01, 1.07830459e+00, 2.92598254e-01,
01470   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 3.50326241e-01},
01471  {0.00000000e+00, 1.07002228e+00, 2.05195422e+00, 3.06772262e-01,
01472   2.43292288e+00, 2.19715052e+00, 2.73911818e-01, 1.14726861e+00,
01473   1.17343465e+00, 5.79909835e-01, 1.01987501e+00, 3.98183329e-01,
01474   5.48083233e-01, 1.61030872e+00, 8.05577240e-01, 1.46152937e+00,
01475   7.42874842e-01, 1.06886174e+00, 9.67471640e-01, 6.11601820e-01,
01476   2.12712296e-01, 7.50000000e-01, 3.69025897e-01, 1.87658077e+00,
01477   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 4.53017475e-01},
01478  {0.00000000e+00, 1.07474947e+00, 1.82470118e+00, 2.94964746e-01,
01479   2.19715052e+00, 2.41404373e+00, 2.87098831e-01, 1.04389169e+00,
01480   1.16525001e+00, 6.26339428e-01, 9.87756703e-01, 4.63568053e-01,
01481   6.13603630e-01, 1.39293185e+00, 8.79669521e-01, 1.77158803e+00,
01482   7.82149443e-01, 9.98597151e-01, 9.13853001e-01, 6.60440693e-01,
01483   2.00637717e-01, 7.50000000e-01, 3.71943861e-01, 2.13407372e+00,
01484   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 5.12682678e-01},
01485  {0.00000000e+00, 4.46290560e-01, 3.54071966e-01, 3.70976416e-01,
01486   2.73911818e-01, 2.87098831e-01, 8.02764197e+00, 3.32339414e-01,
01487   6.59545216e-01, 1.26203255e+00, 2.98137999e-01, 1.51752623e+00,
01488   1.04274830e+00, 4.46999215e-01, 3.50828021e-01, 3.43119584e-01,
01489   3.58749728e-01, 4.78353203e-01, 4.88459165e-01, 7.66309017e-01,
01490   1.07668873e+00, 7.50000000e-01, 4.97590308e+00, 3.11511613e-01,
01491   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 1.44043358e+00},
01492  {0.00000000e+00, 1.33923306e+00, 1.11918465e+00, 4.59297624e-01,
01493   1.14726861e+00, 1.04389169e+00, 3.32339414e-01, 2.99056680e+00,
01494   6.15552047e-01, 5.57103314e-01, 6.78509416e-01, 3.94686522e-01,
01495   5.25369171e-01, 1.08662777e+00, 8.94077901e-01, 7.57447784e-01,
01496   5.54986868e-01, 1.27845679e+00, 9.98770702e-01, 7.34634729e-01,
01497   2.00363838e-01, 7.50000000e-01, 2.99613619e-01, 9.19064864e-01,
01498   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 4.43694156e-01},
01499  {0.00000000e+00, 7.32178470e-01, 1.29683470e+00, 4.51836855e-01,
01500   1.17343465e+00, 1.16525001e+00, 6.59545216e-01, 6.15552047e-01,
01501   4.47513035e+00, 5.70614299e-01, 9.90160946e-01, 6.20055020e-01,
01502   6.09441413e-01, 1.43988866e+00, 9.46471632e-01, 1.96194975e+00,
01503   1.43036819e+00, 8.30226277e-01, 7.40733381e-01, 5.96692220e-01,
01504   5.44285116e-01, 7.50000000e-01, 9.78877039e-01, 1.51243666e+00,
01505   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 6.05136779e-01},
01506  {0.00000000e+00, 8.88728816e-01, 6.16970770e-01, 5.87603719e-01,
01507   5.79909835e-01, 6.26339428e-01, 1.26203255e+00, 5.57103314e-01,
01508   5.70614299e-01, 2.83022396e+00, 6.40800116e-01, 1.74919442e+00,
01509   1.64986005e+00, 6.59934398e-01, 6.27243837e-01, 6.25316723e-01,
01510   6.29014923e-01, 7.22513707e-01, 1.01665478e+00, 2.33821719e+00,
01511   3.02670201e-01, 7.50000000e-01, 7.99863687e-01, 6.25893752e-01,
01512   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 2.07538421e+00},
01513  {0.00000000e+00, 7.66227814e-01, 1.13010166e+00, 2.86099293e-01,
01514   1.01987501e+00, 9.87756703e-01, 2.98137999e-01, 6.78509416e-01,
01515   9.90160946e-01, 6.40800116e-01, 2.92620120e+00, 5.18814877e-01,
01516   1.09961986e+00, 1.25788411e+00, 7.70516817e-01, 1.18387275e+00,
01517   2.18168472e+00, 9.61645918e-01, 9.95647751e-01, 5.70096500e-01,
01518   4.50323287e-01, 7.50000000e-01, 3.59829368e-01, 1.07322036e+00,
01519   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 5.55622697e-01},
01520  {0.00000000e+00, 6.46341735e-01, 4.52559218e-01, 2.47791243e-01,
01521   3.98183329e-01, 4.63568053e-01, 1.51752623e+00, 3.94686522e-01,
01522   6.20055020e-01, 1.74919442e+00, 5.18814877e-01, 3.92994485e+00,
01523   2.33771776e+00, 5.15595552e-01, 5.56038228e-01, 6.65507525e-01,
01524   5.01008003e-01, 5.24107036e-01, 6.77040993e-01, 1.53178711e+00,
01525   6.46886104e-01, 7.50000000e-01, 8.14904569e-01, 5.51569446e-01,
01526   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 3.27192533e+00},
01527  {0.00000000e+00, 7.70359541e-01, 6.04775077e-01, 2.99408166e-01,
01528   5.48083233e-01, 6.13603630e-01, 1.04274830e+00, 5.25369171e-01,
01529   6.09441413e-01, 1.64986005e+00, 1.09961986e+00, 2.33771776e+00,
01530   4.40351686e+00, 6.70496227e-01, 6.21012433e-01, 7.95710012e-01,
01531   9.04471250e-01, 6.98581457e-01, 8.73067477e-01, 1.51039751e+00,
01532   3.74941590e-01, 7.50000000e-01, 5.67675865e-01, 6.92962139e-01,
01533   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 2.13016362e+00},
01534  {0.00000000e+00, 1.03988401e+00, 1.59985542e+00, 4.32746060e-01,
01535   1.61030872e+00, 1.39293185e+00, 4.46999215e-01, 1.08662777e+00,
01536   1.43988866e+00, 6.59934398e-01, 1.25788411e+00, 5.15595552e-01,
01537   6.70496227e-01, 1.58773724e+00, 8.93169424e-01, 1.19675558e+00,
01538   9.99684066e-01, 1.17295383e+00, 1.10674855e+00, 6.68196499e-01,
01539   3.94266130e-01, 7.50000000e-01, 6.20758168e-01, 1.30744195e+00,
01540   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 5.59148347e-01},
01541  {0.00000000e+00, 1.29408826e+00, 8.46142888e-01, 5.27421501e-01,
01542   8.05577240e-01, 8.79669521e-01, 3.50828021e-01, 8.94077901e-01,
01543   9.46471632e-01, 6.27243837e-01, 7.70516817e-01, 5.56038228e-01,
01544   6.21012433e-01, 8.93169424e-01, 3.84141803e+00, 1.05550534e+00,
01545   9.60208581e-01, 1.24349521e+00, 1.07552180e+00, 7.58279920e-01,
01546   2.75343404e-01, 7.50000000e-01, 3.20901839e-01, 9.56295438e-01,
01547   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 5.77523805e-01},
01548  {0.00000000e+00, 9.03456780e-01, 1.33890747e+00, 2.89534285e-01,
01549   1.46152937e+00, 1.77158803e+00, 3.43119584e-01, 7.57447784e-01,
01550   1.96194975e+00, 6.25316723e-01, 1.18387275e+00, 6.65507525e-01,
01551   7.95710012e-01, 1.19675558e+00, 1.05550534e+00, 2.54088209e+00,
01552   1.33504131e+00, 8.89983529e-01, 8.32948914e-01, 6.49448913e-01,
01553   3.35176014e-01, 7.50000000e-01, 3.94549334e-01, 2.10683180e+00,
01554   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 6.53380354e-01},
01555  {0.00000000e+00, 7.00798809e-01, 8.61808201e-01, 4.30504374e-01,
01556   7.42874842e-01, 7.82149443e-01, 3.58749728e-01, 5.54986868e-01,
01557   1.43036819e+00, 6.29014923e-01, 2.18168472e+00, 5.01008003e-01,
01558   9.04471250e-01, 9.99684066e-01, 9.60208581e-01, 1.33504131e+00,
01559   4.07760419e+00, 9.28286966e-01, 8.20208528e-01, 5.61449723e-01,
01560   1.65111328e+00, 7.50000000e-01, 3.78768704e-01, 1.02308924e+00,
01561   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 5.39632804e-01},
01562  {0.00000000e+00, 1.28966428e+00, 1.11706882e+00, 9.89678273e-01,
01563   1.06886174e+00, 9.98597151e-01, 4.78353203e-01, 1.27845679e+00,
01564   8.30226277e-01, 7.22513707e-01, 9.61645918e-01, 5.24107036e-01,
01565   6.98581457e-01, 1.17295383e+00, 1.24349521e+00, 8.89983529e-01,
01566   9.28286966e-01, 1.44062735e+00, 1.36207698e+00, 7.99071364e-01,
01567   5.65535441e-01, 7.50000000e-01, 5.19882078e-01, 9.51265394e-01,
01568   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 5.83974254e-01},
01569  {0.00000000e+00, 1.31725380e+00, 1.03197349e+00, 6.01385571e-01,
01570   9.67471640e-01, 9.13853001e-01, 4.88459165e-01, 9.98770702e-01,
01571   7.40733381e-01, 1.01665478e+00, 9.95647751e-01, 6.77040993e-01,
01572   8.73067477e-01, 1.10674855e+00, 1.07552180e+00, 8.32948914e-01,
01573   8.20208528e-01, 1.36207698e+00, 1.80640078e+00, 1.06764169e+00,
01574   3.05841935e-01, 7.50000000e-01, 5.30232118e-01, 8.78596534e-01,
01575   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 7.79516037e-01},
01576  {0.00000000e+00, 1.04499203e+00, 6.37811920e-01, 6.38902701e-01,
01577   6.11601820e-01, 6.60440693e-01, 7.66309017e-01, 7.34634729e-01,
01578   5.96692220e-01, 2.33821719e+00, 5.70096500e-01, 1.53178711e+00,
01579   1.51039751e+00, 6.68196499e-01, 7.58279920e-01, 6.49448913e-01,
01580   5.61449723e-01, 7.99071364e-01, 1.06764169e+00, 2.69825619e+00,
01581   2.36794202e-01, 7.50000000e-01, 5.65836205e-01, 6.55650683e-01,
01582   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 1.77511928e+00},
01583  {0.00000000e+00, 2.63609841e-01, 2.96793416e-01, 1.68818010e-01,
01584   2.12712296e-01, 2.00637717e-01, 1.07668873e+00, 2.00363838e-01,
01585   5.44285116e-01, 3.02670201e-01, 4.50323287e-01, 6.46886104e-01,
01586   3.74941590e-01, 3.94266130e-01, 2.75343404e-01, 3.35176014e-01,
01587   1.65111328e+00, 5.65535441e-01, 3.05841935e-01, 2.36794202e-01,
01588   5.26606678e+01, 7.50000000e-01, 9.69642510e-01, 2.59266956e-01,
01589   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 5.43022417e-01},
01590  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01591   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01592   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01593   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01594   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01595   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01596   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 7.50000000e-01},
01597  {0.00000000e+00, 4.49686798e-01, 4.85608019e-01, 1.07830459e+00,
01598   3.69025897e-01, 3.71943861e-01, 4.97590308e+00, 2.99613619e-01,
01599   9.78877039e-01, 7.99863687e-01, 3.59829368e-01, 8.14904569e-01,
01600   5.67675865e-01, 6.20758168e-01, 3.20901839e-01, 3.94549334e-01,
01601   3.78768704e-01, 5.19882078e-01, 5.30232118e-01, 5.65836205e-01,
01602   9.69642510e-01, 7.50000000e-01, 1.03387565e+01, 3.81794898e-01,
01603   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 8.10366134e-01},
01604  {0.00000000e+00, 1.00010336e+00, 1.61300149e+00, 2.92598254e-01,
01605   1.87658077e+00, 2.13407372e+00, 3.11511613e-01, 9.19064864e-01,
01606   1.51243666e+00, 6.25893752e-01, 1.07322036e+00, 5.51569446e-01,
01607   6.92962139e-01, 1.30744195e+00, 9.56295438e-01, 2.10683180e+00,
01608   1.02308924e+00, 9.51265394e-01, 8.78596534e-01, 6.55650683e-01,
01609   2.59266956e-01, 7.50000000e-01, 3.81794898e-01, 2.12220220e+00,
01610   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 5.73996058e-01},
01611  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01612   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01613   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01614   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01615   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01616   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01617   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 7.50000000e-01},
01618  {0.00000000e+00, 1.70000000e-01, 1.70000000e-01, 1.70000000e-01,
01619   1.70000000e-01, 1.70000000e-01, 1.70000000e-01, 1.70000000e-01,
01620   1.70000000e-01, 1.70000000e-01, 1.70000000e-01, 1.70000000e-01,
01621   1.70000000e-01, 1.70000000e-01, 1.70000000e-01, 1.70000000e-01,
01622   1.70000000e-01, 1.70000000e-01, 1.70000000e-01, 1.70000000e-01,
01623   1.70000000e-01, 1.70000000e-01, 1.70000000e-01, 1.70000000e-01,
01624   1.70000000e-01, 1.33300000e+00, 1.70000000e-01, 1.70000000e-01},
01625  {0.00000000e+00, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01626   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01627   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01628   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01629   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01630   7.50000000e-01, 7.50000000e-01, 7.50000000e-01, 7.50000000e-01,
01631   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 7.50000000e-01},
01632  {0.00000000e+00, 7.19479599e-01, 5.02168751e-01, 3.50326241e-01,
01633   4.53017475e-01, 5.12682678e-01, 1.44043358e+00, 4.43694156e-01,
01634   6.05136779e-01, 2.07538421e+00, 5.55622697e-01, 3.27192533e+00,
01635   2.13016362e+00, 5.59148347e-01, 5.77523805e-01, 6.53380354e-01,
01636   5.39632804e-01, 5.83974254e-01, 7.79516037e-01, 1.77511928e+00,
01637   5.43022417e-01, 7.50000000e-01, 8.10366134e-01, 5.73996058e-01,
01638   7.50000000e-01, 1.70000000e-01, 7.50000000e-01, 2.91088108e+00}};
01639 
01640 
01641 /** Additional bit scale multiplier for BLOSUM62_20A matrix */
01642 #define BLOSUM62_20A_SCALE_MULTIPLIER 0.9666
01643 /** Additional bit scale multiplier for BLOSUM62_20B matrix */
01644 #define BLOSUM62_20B_SCALE_MULTIPLIER 0.9344
01645 
01646 SFreqRatios*
01647 _PSIMatrixFrequencyRatiosNew(const char* matrix_name)
01648 {
01649     unsigned int i, j;          /* loop indices */
01650     SFreqRatios* retval = NULL; /* the return value */
01651 
01652     ASSERT(matrix_name);
01653 
01654     retval = (SFreqRatios*) malloc(sizeof(SFreqRatios));
01655     if ( !retval ) {
01656         return NULL;
01657     }
01658 
01659     retval->data = (double**) _PSIAllocateMatrix(BLASTAA_SIZE, BLASTAA_SIZE, 
01660                                                  sizeof(double));
01661     if ( !retval->data ) {
01662         return _PSIMatrixFrequencyRatiosFree(retval);
01663     }
01664 
01665     if ( !strcmp(matrix_name, "BLOSUM62") ||
01666          !strcmp(matrix_name, "BLOSUM62_20")) {
01667         for (i = 0; i < BLASTAA_SIZE; i++) {
01668             for (j = 0; j < BLASTAA_SIZE; j++) {
01669                 retval->data[i][j] = BLOSUM62_FREQRATIOS[i][j];
01670             }
01671         }
01672         retval->bit_scale_factor = 2;
01673     } else if ( !strcmp(matrix_name, "BLOSUM62_20A")) {
01674         for (i = 0; i < BLASTAA_SIZE; i++) {
01675             for (j = 0; j < BLASTAA_SIZE; j++) {
01676                 retval->data[i][j] = 
01677                     BLOSUM62_20A_SCALE_MULTIPLIER * BLOSUM62_FREQRATIOS[i][j];
01678             }
01679         }
01680         retval->bit_scale_factor = 2;
01681     } else if ( !strcmp(matrix_name, "BLOSUM62_20B")) {
01682         for (i = 0; i < BLASTAA_SIZE; i++) {
01683             for (j = 0; j < BLASTAA_SIZE; j++) {
01684                 retval->data[i][j] =
01685                     BLOSUM62_20B_SCALE_MULTIPLIER * BLOSUM62_FREQRATIOS[i][j];
01686             }
01687         }
01688         retval->bit_scale_factor = 2;
01689     } else if ( !strcmp(matrix_name, "BLOSUM45") ) {
01690         for (i = 0; i < BLASTAA_SIZE; i++) {
01691             for (j = 0; j < BLASTAA_SIZE; j++) {
01692                 retval->data[i][j] = BLOSUM45_FREQRATIOS[i][j];
01693             }
01694         }
01695         retval->bit_scale_factor = 3;
01696     } else if ( !strcmp(matrix_name, "BLOSUM80") ) {
01697         for (i = 0; i < BLASTAA_SIZE; i++) {
01698             for (j = 0; j < BLASTAA_SIZE; j++) {
01699                 retval->data[i][j] = BLOSUM80_FREQRATIOS[i][j];
01700             }
01701         }
01702         retval->bit_scale_factor = 2;
01703     } else if ( !strcmp(matrix_name, "BLOSUM50") ) {
01704         for (i = 0; i < BLASTAA_SIZE; i++) {
01705             for (j = 0; j < BLASTAA_SIZE; j++) {
01706                 retval->data[i][j] = BLOSUM50_FREQRATIOS[i][j];
01707             }
01708         }
01709         retval->bit_scale_factor = 2;
01710     } else if ( !strcmp(matrix_name, "BLOSUM90") ) {
01711         for (i = 0; i < BLASTAA_SIZE; i++) {
01712             for (j = 0; j < BLASTAA_SIZE; j++) {
01713                 retval->data[i][j] = BLOSUM90_FREQRATIOS[i][j];
01714             }
01715         }
01716         retval->bit_scale_factor = 2;
01717     } else if ( !strcmp(matrix_name, "PAM30") ) {
01718         for (i = 0; i < BLASTAA_SIZE; i++) {
01719             for (j = 0; j < BLASTAA_SIZE; j++) {
01720                 retval->data[i][j] = PAM30_FREQRATIOS[i][j];
01721             }
01722         }
01723         retval->bit_scale_factor = 2;
01724     } else if ( !strcmp(matrix_name, "PAM70") ) {
01725         for (i = 0; i < BLASTAA_SIZE; i++) {
01726             for (j = 0; j < BLASTAA_SIZE; j++) {
01727                 retval->data[i][j] = PAM70_FREQRATIOS[i][j];
01728             }
01729         }
01730         retval->bit_scale_factor = 2;
01731     } else if ( !strcmp(matrix_name, "PAM250") ) {
01732         for (i = 0; i < BLASTAA_SIZE; i++) {
01733             for (j = 0; j < BLASTAA_SIZE; j++) {
01734                 retval->data[i][j] = PAM250_FREQRATIOS[i][j];
01735             }
01736         }
01737         retval->bit_scale_factor = 2;
01738     } else {
01739         retval = _PSIMatrixFrequencyRatiosFree(retval);
01740     }
01741 
01742     return retval;
01743 }
01744 
01745 SFreqRatios*
01746 _PSIMatrixFrequencyRatiosFree(SFreqRatios* freq_ratios)
01747 {
01748     if ( !freq_ratios )
01749         return NULL;
01750 
01751     if (freq_ratios->data) {
01752         _PSIDeallocateMatrix((void**) freq_ratios->data, BLASTAA_SIZE);
01753     }
01754 
01755     sfree(freq_ratios);
01756     return NULL;
01757 }
01758 
01759 

Generated on Sun Dec 6 22:17:25 2009 for NCBI C++ ToolKit by  doxygen 1.4.6
Modified on Mon Dec 07 16:20:51 2009 by modify_doxy.py rev. 173732