Caenorhabditis elegans essential gene hmp-2, encoding embryonic body elongation factor, Armadillo-like beta-catenin, HuMPback, dorsal lumps, defective body elongation in embryos, MAternal effect Dumpy mad-1.
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SUMMARY back to top
Summary
[Wormbase] hmp-2 encodes a beta-catenin; HMP-2 activity is required during embryonic development for cell adhesion at adherens junctions, cell migration, and body morphogenesis; as a beta-catenin, HMP-2 likely functions solely as part of a cadherin-catenin complex, as in yeast two-hybrid assays, HMP-2 is the only C. elegans beta-catenin that binds HMP-1/alpha-catenin and HMR-1/cadherin; additionally, in the embryo, HMP-2 co-localizes to sites of epithelial cell contacts with HMP-1 and HMR-1/cadherin; however, despite its normal role in embryonic cell adhesion, HMP-2 can activate transcription and when overexpressed in vivo, can partially rescue vulval defects produced by loss of BAR-1/beta-catenin, suggesting that HMP-2 has retained the ability to interact with the Wnt signaling pathway.
Wormbase predicts one model from 2 genes.

AceView summary
According to AceView, this gene is expressed at high level, 2.3 times the average gene in this release, at all stages of development [Kohara cDNAs]. The sequence of this gene is defined by 30 cDNA clones.
The gene contains 4 distinct gt-ag introns. Transcription produces one mRNA. There are 2 validated alternative polyadenylation sites (see the diagram).
The spliced mRNA putatively encodes a good protein, containing Armadillo domain [Pfam].
Function: There are 10 articles specifically referring to this gene in PubMed. In addition we point below to 19 abstracts. This essential gene is associated to a phenotype (Embryonic Lethal, MAternal effect Dumpy, DumPY : shorter than wild-type, exaggerated pseudocleavage, fragile animal, may explode at vulva, HuMPback, dorsal lumps, defective body elongation in embryos, multiple cavities or vesicles during early embryogenesis, slow embryonic cell division, UNCoordinated locomotion, aberrant spindle orientation in anterior or posterior cell in 2-cell embryos, EMS embryonic blastomere fails to extend anteriorly, division axis of ABa or ABp aberrant). Functionally, the gene has been proposed to participate in a process (pseudocleavage (sensu Nematoda)).

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_I, links to other databases and other names back to top ?
Map: This essential gene hmp-2 maps on chomosome I at position +26.30 (interpolated). In AceView, it covers 3.11 kb, from 14739556 to 14742668 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
as Other names: The gene is also known mad-1, in Wormgenes/AceView by its positional name 1P333, in Wormbase by its cosmid.number name K05C4.6, in NextDB, the Nematode expression pattern database, as CEYK2322.
Closest AceView homologs in other species back to top ?
The closest human genes, according to BlastP, are the AceView genes JUP (e=2 10^-77), CTNNB1 (e=10^-76).
The closest mouse genes, according to BlastP, are the AceView genes Jup (e=4 10^-77), Ctnnb1 (e=8 10^-77).
The closest A.thaliana genes, according to BlastP, are the AceView genes AT1G08315 (e=3 10^-04), AT1G08310 (e=3 10^-04)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_I back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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