Summary
[Wormbase] hlh-3 encodes a basic helix-loop-helix transcription factor homologous to Drosophila Achaete-scute; in vitro, HLH-3 can heterodimerize, and bind an E-box-containing probe, with HLH-2, the C. elegans E/daughterless ortholog with which it is coexpressed in the nuclei of embryonic neuronal precursors
.
Wormbase predicts one model.
AceView summary
According to AceView, this gene is
moderately expressed, only 30.4% of the average gene in this release. The
sequence of this gene is defined by
4 cDNA clones.
The gene contains
1 gt-ag intron. Transcription produces one mRNA.
The spliced mRNA putatively encodes
a good protein, altogether
2 different isoforms (1 complete, 1 COOH complete), containing Basic helix-loop-helix dimerisation region bHLH
domain [Pfam].
Function: There are
2 articles specifically referring to this gene in PubMed. In addition we point
below to 5 abstracts. This gene is associated to a
phenotype. Functionally, the gene has been proposed to participate in a
process (regulation of transcription). Proteins are expected to have molecular
function (transcription regulator activity) and to
localize in various compartments (mitochondrion, nucleus).
Please quote:
AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map: This gene hlh-3 maps on chomosome II at position +1.18 (interpolated). In AceView, it covers
1.31 kb, from 9086528 to 9087841 (WS190), on the direct strand.
Links to: WormBase,
RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 2J377, in Wormbase by its cosmid.number name T24B8.6.
The closest human genes, according to BlastP, are the AceView genes
ASCL4 (e=5 10^-07),
ASCL3 (e=2 10^-06),
PAH (e=6 10^-06),
ASCL1 (e=8 10^-06).
The closest mouse genes, according to BlastP, are the AceView genes
Ascl3 (e=10^-06),
Ascl1 (e=3 10^-06),
Ascl2 (e=5 10^-05),
Bhlhb8 (e=7 10^-05).
The closest A.thaliana gene, according to BlastP, is the AceView gene
UNE10 (e=2 10^-04)
Legend
Introns are depicted by broken lines; the height of the top of each intron reflects the relative number of clones supporting this intron.
]^[ A pink broken line denotes an intron with standard boundaries (gt-ag or gc-ag) that is exactly supported (i.e. a cDNA sequence exactly matches the genome over 16 bp, 8 on both sides of the intron).
] ^ ] A blue broken line denotes non-standard introns, exactly supported, but with non-standard at-ac or any other boundaries.
]-[ Pink and
] - ] blue straight lines represent 'fuzzy' introns of the standard and non-standard types respectively, those introns do not follow the 16 bp rule. Black straight lines ]-[denote gaps in the alignments.
Exons: Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). Flags identify validated endings: cap site on the 5' side, polyadenylation site on the 3' side. Filled flags correspond to frequent events while empty flags have lesser supporting cDNAs (yet all are validated); at the 3' side, black flags are associated to the main AATAAA signal,
blue flags to any single letter variant of the main . More explanations are given in the
gene help file
