Summary
[Wormbase] her-1 generates two transcripts, the larger of which encodes a small, secreted, cysteine-rich protein (HER-1A) required for normal sex determination in wild-type XO male animals, while being dispensable for sex determination in XX hermaphrodites; transcription of her-1 in XX animals is repressed by SDC-2; HER-1A protein has two all-helical domains, with fourteen conserved cysteine residues forming seven disulfide bonds, at least eight of which residues are critical for function in vivo; HER-1A has no known homologs except in other nematodes (e.g., Brugia malayi), and does not structurally resemble other well-known secreted proteins; HER-1A inhibits the receptor TRA-2A in vivo, and binds it in vitro; HER-1A functions nonautonomously and requires a signal sequence for biological activity; the her-1(n695gf) mutation alters a site in the her-1 promoter bound by SDC-2, partially transforms XX animals into phenotypic males, and requires sup-26 and sup-27 to do so.
Wormbase predicts 2 models.

AceView summary
According to AceView, this gene is moderately expressed, only 38.0% of the average gene in this release. The sequence of this gene is defined by 5 cDNA clones.
The gene contains 3 distinct gt-ag introns. Transcription produces one mRNA.
The spliced mRNA putatively encodes a good protein, altogether 2 different isoforms (2 COOH complete), some containing Protein of unknown function Her-1 domain [Pfam].
Function: There are 25 articles specifically referring to this gene in PubMed. In addition we point below to 107 abstracts. This gene is associated to a phenotype (HERmaphrodization of XO animals).

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Map: This gene her-1 maps on chomosome V at position +2.03 (interpolated). In AceView, it covers 4.43 kb, from 9697101 to 9701529 (WS190), on the direct strand.
Links to: WormBase, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 5K181, in Wormbase by its cosmid.number name ZK287.8.

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