Summary
[Wormbase] gpi-1 encodes two isoforms of a putative glucose 6-phosphate isomerase orthologous to human GPI (OMIM:172400, mutated in chronic hemolytic anemia); gpi-1 is required both for embryonic viability and (paradoxically) for normally short lifespan; gpi-1 is expressed in neurons and intestine.
Wormbase predicts 2 models, but Caenorhabditis elegans cDNA sequences in GenBank, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 4 spliced variants.

AceView summary
Expression: According to AceView, this gene is expressed at very high level, 6.2 times the average gene in this release, at all stages of development [Kohara cDNAs], in most tissues, including intestine, gonad and nervous system [Kohara in situ hybridisation to RNA, see NextDB]. The sequence of this gene is defined by 81 cDNA clones, some from whole animal (seen 6 times), whole worm (once). We annotate structural defects or features in 6 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 6 distinct introns (5 gt-ag, 1 other). Transcription produces 4 alternatively spliced mRNAs. There are 3 probable alternative promotors and 5 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by by truncation of the 5' end, overlapping exons with different boundaries.
Protein coding potential: The 4 spliced mRNAs putatively encode good proteins, altogether 3 different isoforms (3 complete, 2 COOH complete), some containing Phosphoglucose isomerase (PGI) domain [Pfam], a second peroximal domain [Psort2].
Function: There are 3 articles specifically referring to this gene in PubMed. This essential gene is associated to a phenotype (extends adult lifespan, abnormal DAuer Formation, Embryonic Lethal). Functionally, the gene has been proposed to participate in processes (gluconeogenesis, glycolysis). Proteins are expected to have molecular function (glucose-6-phosphate isomerase activity).

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Map: This essential gene gpi-1 maps on chomosome I at position +19.18 (interpolated). In AceView, it covers 5.35 kb, from 13576234 to 13581581 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 1O173, in Wormbase by its cosmid.number name Y87G2A.8, in NextDB, the Nematode expression pattern database, as CEYK3744.

The closest human gene, according to BlastP, is the AceView gene GPIandPDCD2L (e=10^-39).
The closest mouse genes, according to BlastP, are the AceView genes Gpi1 (e=6 10^-40), LOC669429 (e=10^-39).
The closest A.thaliana gene, according to BlastP, is the AceView gene AT5G42740 (e=2 10^-15)

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNA clones supporting each intron. Superimposed introns of the same color are identical, of different colors are different.
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. Details on tissue of origin for each intron and exon is available from the intron and exons table. Good predicted proteins are in pink, yellow proteins may be partial or unconvincing, green are uORFs. Proteins supported by a single continuous GenBank accession lead to underlining the name/ending of the variant. Names not underlined result from cDNA concatenation in the coding region and should be experimentally checked.
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