Summary
[Wormbase] gop-2 encodes a member of the conserved hypothetical ATP binding protein family that affects embryonic viability, growth, and fertility
.
Wormbase predicts one model.
AceView summary
According to AceView, this gene is
well expressed, 1.0 times the average gene in this release, mostly from L1 larvae to adult [Kohara cDNAs]. The
sequence of this gene is defined by
13 cDNA clones, some from whole animal (seen once).
The gene contains
4 distinct gt-ag introns. Transcription produces one mRNA. There are 2 validated
alternative polyadenylation sites (see the
diagram).
The spliced mRNA putatively encodes
a good protein, containing Protein of unknown function, ATP binding
domain [Pfam], a coiled coil stretch
[Psort2].
Function: There is
one article specifically referring to this gene in PubMed. In addition we point
below to one abstract. This essential gene is associated to a
phenotype (abnormal CyToplasmic Appearance, Embryonic Lethal, Gro-1 OPeron gene, Larval arrest, SLow growth, STerile Progeny, large cytoplasmic granules in early embryos). Proteins are expected to have molecular
function (nucleotide binding activity) and to
localize in cytoplasm.
Please quote:
AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map: This essential gene gop-2 maps on chomosome III at position -1.90 (interpolated). In AceView, it covers
1.49 kb, from 5258982 to 5260469 (WS190), on the direct strand.
Links to: WormBase,
NextDB,
RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 3G349, in Wormbase by its cosmid.number name C34E10.2, in NextDB, the Nematode expression pattern database, as CEYK8443.
The closest human gene, according to BlastP, is the AceView gene
XAB1 (e=10^-93).
The closest mouse gene, according to BlastP, is the AceView gene
Xab1 (e=3 10^-93).
The closest A.thaliana gene, according to BlastP, is the AceView gene
QQT2 (e=9 10^-80)
Legend
Introns are depicted by broken lines; the height of the top of each intron reflects the relative number of clones supporting this intron.
]^[ A pink broken line denotes an intron with standard boundaries (gt-ag or gc-ag) that is exactly supported (i.e. a cDNA sequence exactly matches the genome over 16 bp, 8 on both sides of the intron).
] ^ ] A blue broken line denotes non-standard introns, exactly supported, but with non-standard at-ac or any other boundaries.
]-[ Pink and
] - ] blue straight lines represent 'fuzzy' introns of the standard and non-standard types respectively, those introns do not follow the 16 bp rule. Black straight lines ]-[denote gaps in the alignments.
Exons: Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). Flags identify validated endings: cap site on the 5' side, polyadenylation site on the 3' side. Filled flags correspond to frequent events while empty flags have lesser supporting cDNAs (yet all are validated); at the 3' side, black flags are associated to the main AATAAA signal,
blue flags to any single letter variant of the main . More explanations are given in the
gene help file
