Caenorhabditis elegans gene gdi-1, encoding rab GDP Dissociation Inhibitor.
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SUMMARY back to top
Summary
[Wormbase] gdi-1 encodes a member of the Rab GDP dissociation inhibitor (GDI) family with high similarity to Drosophila Gdi; expressed around the pharyngeal, vulval, and tail regions.
Wormbase predicts 2 models.

AceView summary
Expression: According to AceView, this gene is expressed at very high level, 15.9 times the average gene in this release, at all stages of development [Kohara cDNAs]. The sequence of this gene is defined by 209 cDNA clones, some from whole animal (seen 15 times). We annotate structural defects or features in 12 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 3 distinct gt-ag introns. Transcription produces 2 alternatively spliced mRNAs. There are 7 validated alternative polyadenylation sites (see the diagram). 44 bp of this gene are antisense to spliced gene 4P555, raising the possibility of regulated alternate expression.
Protein coding potential: The 2 spliced mRNAs putatively encode good proteins, altogether 2 different isoforms (2 complete, 2 COOH complete), some containing Rab GTPase activator domain [Pfam].
Function: There is 0 article specifically referring to this gene in PubMed. In addition we point below to 2 abstracts. This gene is associated to a phenotype (oogenic protein copurified with chromatin). Functionally, the gene has been proposed to participate in a process (regulation of GTPase activity). Proteins are expected to localize in cytoplasm.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_IV, links to other databases and other names back to top ?
Map: This gene gdi-1 maps on chomosome IV at position +12.91 (interpolated). In AceView, it covers 2.08 kb, from 14792846 to 14790765 (WS190), on the reverse strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 4P556, in Wormbase by its cosmid.number name Y57G11C.10, in NextDB, the Nematode expression pattern database, as CEYK73.
Closest AceView homologs in other species back to top ?
The closest human genes, according to BlastP, are the AceView genes GDI2 (e= 10^-128), GDI1 (e= 10^-127).
The closest mouse genes, according to BlastP, are the AceView genes Gdi1 (e= 10^-159), Gdi2 (e= 10^-158).
The closest A.thaliana genes, according to BlastP, are the AceView genes AT5G09550 (e= 10^-132), ATGDI2 (e= 10^-128), ATGDI1 (e= 10^-127)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNA clones supporting each intron. Superimposed introns of the same color are identical, of different colors are different.
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. Details on tissue of origin for each intron and exon is available from the intron and exons table. Good predicted proteins are in pink, yellow proteins may be partial or unconvincing, green are uORFs. Proteins supported by a single continuous GenBank accession lead to underlining the name/ending of the variant. Names not underlined result from cDNA concatenation in the coding region and should be experimentally checked.
More legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_IV back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA:.a, .b Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function and related genes DC

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare all variants, their summarized annotations, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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