Caenorhabditis elegans essential gene frh-1, encoding FRataxin Homolog, loss of function increases sensitivity to oxidative stress, impairs respiration, reduces lifespan, and causes lethality in a mitochondrial complex II mutant.
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SUMMARY back to top
Summary
[Wormbase] frh-1 encodes the C. elegans frataxin ortholog; by homology, FRH-1 is predicted to be a mitochondrial protein required for biogenesis of iron-sulfur clusters, co-factors necessary for proper function of electron transport chain proteins; in C. elegans, loss of frh-1 activity via RNAi results in small body size, pale coloration, reduced egg-laying and fertility, altered responses to oxidative stress, and a significant lifespan extension.
Wormbase predicts one model.

AceView summary
According to AceView, this gene is well expressed, 0.5 times the average gene in this release. The sequence of this gene is defined by 7 cDNA clones, some from whole animal (seen once).
The gene contains 2 distinct gt-ag introns. Transcription produces one mRNA. There are 2 validated alternative polyadenylation sites (see the diagram).
The spliced mRNA putatively encodes a good protein, containing Frataxin-like domain [Pfam].
Function: There are 3 articles specifically referring to this gene in PubMed. In addition we point below to 2 abstracts. This essential gene is associated to a phenotype (embryonic lethal, partial, SLow growth, UNCoordinated locomotion, EGg Laying defective, EATing: abnormal pharyngeal pumping, abnormal oxidative stress response, shortens adult lifespan). Proteins are expected to localize in mitochondrion.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_II, links to other databases and other names back to top ?
Map: This essential gene frh-1 maps on chomosome II at position -0.67 (interpolated). In AceView, it covers 0.90 kb, from 5917388 to 5918285 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 2G207, in Wormbase by its cosmid.number name F59G1.7, in NextDB, the Nematode expression pattern database, as CEYK9540.
Closest AceView homologs in other species back to top ?
The closest human gene, according to BlastP, is the AceView gene FXN (e=9 10^-24).
The closest mouse gene, according to BlastP, is the AceView gene Fxn (e=10^-24).
The closest A.thaliana gene, according to BlastP, is the AceView gene ATFH\/FH (e=2 10^-12)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_II back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Merci !