Caenorhabditis elegans essential gene eif-3.F, encoding eukaryotic Initiation Factor.
TABLE OF CONTENTS / OPEN CLOSE ALL PARAGRAPHS
SUMMARY back to top
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Wormbase predicts one model
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AceView summary
According to AceView, this gene is expressed at high level, 2.1 times the average gene in this release, at all stages of development [Kohara cDNAs]. The sequence of this gene is defined by 28 cDNA clones.
The gene contains 3 distinct gt-ag introns. Transcription produces one mRNA. There are 3 validated alternative polyadenylation sites (see the diagram).
The spliced mRNA putatively encodes a good protein, containing Mov34/MPN/PAD-1 domain [Pfam], a coiled coil stretch [Psort2].
Function:. This essential gene is associated to a phenotype (DumPY : shorter than wild-type, Embryonic Lethal, Larval arrest, STerile Progeny, various morphological defects, shared oogenic and spermatogenic protein copurified with chromatin).

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_II, links to other databases and other names back to top ?
Map: This essential gene eif-3.F maps on chomosome II at position +1.36 (interpolated). In AceView, it covers 2.33 kb, from 9331566 to 9333891 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 2J623, in Wormbase by its cosmid.number name D2013.7, in NextDB, the Nematode expression pattern database, as CEYK1718.
Closest AceView homologs in other species back to top ?
The closest human genes, according to BlastP, are the AceView genes EIF3S5 (e=2 10^-44), hCG_15200 (e=2 10^-44).
The closest mouse gene, according to BlastP, is the AceView gene Eif3s5 (e=9 10^-45).
The closest A.thaliana gene, according to BlastP, is the AceView gene EIF2 (e=2 10^-22)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_II back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Merci !