Summary
[Wormbase] The dpy-30 gene encodes an essential nuclear protein required for hermaphrodite dosage compensation as well as normal male development; DPY-30 is expressed ubiquitously throughout development and can be detected in two different multiprotein complexes: the SDC complex involved in dosage compensation and a second complex containing NOX-1 (a WD repeat-containing protein) and ASH-2 (a trithorax-related protein) that is homologous to the yeast Set1p complex involved in epigenetic regulation of transcription
.
Wormbase predicts one model.
AceView summary
According to AceView, this gene is
expressed at high level, 3.3 times the average gene in this release, mostly in embryos, and some at all stages of development [Kohara cDNAs]. The
sequence of this gene is defined by
44 cDNA clones. We annotate
structural defects or features in 4 cDNA clones.
The gene contains
1 gt-ag intron. Transcription produces one mRNA. There are 2 validated
alternative polyadenylation sites (see the
diagram).
The spliced mRNA putatively encodes
a good protein, containing Dpy-30, conserved site
domain [Pfam].
Function: There are
7 articles specifically referring to this gene in PubMed. In addition we point
below to 17 abstracts. This essential gene is associated to a
phenotype (DumPY : shorter than wild-type, uncoordinated locomotion, sluggish, shared oogenic and spermatogenic protein copurified with chromatin).
Please quote:
AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map: This essential gene dpy-30 maps on chomosome V at position +3.85 (interpolated). In AceView, it covers
0.67 kb, from 12191496 to 12192161 (WS190), on the direct strand.
Links to: WormBase,
NextDB,
RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 5M671, in Wormbase by its cosmid.number name ZK863.6, in NextDB, the Nematode expression pattern database, as CEYK2336.
The closest human gene, according to BlastP, is the AceView gene
MEMO1 (e=9 10^-13).
The closest mouse gene, according to BlastP, is the AceView gene
2810410M20Rik (e=5 10^-13)
Legend
Introns are depicted by broken lines; the height of the top of each intron reflects the relative number of clones supporting this intron.
]^[ A pink broken line denotes an intron with standard boundaries (gt-ag or gc-ag) that is exactly supported (i.e. a cDNA sequence exactly matches the genome over 16 bp, 8 on both sides of the intron).
] ^ ] A blue broken line denotes non-standard introns, exactly supported, but with non-standard at-ac or any other boundaries.
]-[ Pink and
] - ] blue straight lines represent 'fuzzy' introns of the standard and non-standard types respectively, those introns do not follow the 16 bp rule. Black straight lines ]-[denote gaps in the alignments.
Exons: Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). Flags identify validated endings: cap site on the 5' side, polyadenylation site on the 3' side. Filled flags correspond to frequent events while empty flags have lesser supporting cDNAs (yet all are validated); at the 3' side, black flags are associated to the main AATAAA signal,
blue flags to any single letter variant of the main . More explanations are given in the
gene help file
