Summary
[Wormbase] dpy-28 encodes a non-SMC condensin subunit homolog, similar to XCAP-D2 in Xenopus, Cnd1 in S. pombe, and Ycs4p in S. cerevisiae, that is required for negative, chromosome-wide regulation of X-chromosomal genes in XX but not XO animals (dosage compensation), and for some undetermined aspect of body morphogenesis; DPY-28 is part of a multiprotein 'dosage compensation' complex with DPY-26, DPY-27 and MIX-1
.
Wormbase predicts one model.
AceView summary
According to AceView, this gene is
expressed at high level, 1.8 times the average gene in this release, at all stages of development [Kohara cDNAs]. The
sequence of this gene is defined by
24 cDNA clones. We annotate
structural defects or features in 9 cDNA clones.
The gene contains
15 distinct gt-ag introns. Transcription produces one mRNA. There are 2 validated
alternative polyadenylation sites (see the
diagram).
The spliced mRNA putatively encodes
a good protein, containing a coiled coil stretch
[Psort2].
Function: There are
6 articles specifically referring to this gene in PubMed. In addition we point
below to 48 abstracts. This essential gene is associated to a
phenotype (DumPY : shorter than wild-type, Embryonic Lethal, UNCoordinated locomotion, oogenic protein copurified with chromatin).
Please quote:
AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map: This essential gene dpy-28 maps on chomosome III at position +4.13 (interpolated). In AceView, it covers
14.21 kb, from 10763029 to 10777240 (WS190), on the direct strand.
Links to: WormBase,
NextDB,
RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 3L865, in Wormbase by its cosmid.number name Y39A1B.3, in NextDB, the Nematode expression pattern database, as CEYK1117.
The closest human gene, according to BlastP, is the AceView gene
NCAPD2 (e=4 10^-19).
The closest mouse gene, according to BlastP, is the AceView gene
Ncapd2 (e=4 10^-25).
The closest A.thaliana gene, according to BlastP, is the AceView gene
AT3G57060 (e=2 10^-20)
Legend
Introns are depicted by broken lines; the height of the top of each intron reflects the relative number of clones supporting this intron.
]^[ A pink broken line denotes an intron with standard boundaries (gt-ag or gc-ag) that is exactly supported (i.e. a cDNA sequence exactly matches the genome over 16 bp, 8 on both sides of the intron).
] ^ ] A blue broken line denotes non-standard introns, exactly supported, but with non-standard at-ac or any other boundaries.
]-[ Pink and
] - ] blue straight lines represent 'fuzzy' introns of the standard and non-standard types respectively, those introns do not follow the 16 bp rule. Black straight lines ]-[denote gaps in the alignments.
Exons: Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). Flags identify validated endings: cap site on the 5' side, polyadenylation site on the 3' side. Filled flags correspond to frequent events while empty flags have lesser supporting cDNAs (yet all are validated); at the 3' side, black flags are associated to the main AATAAA signal,
blue flags to any single letter variant of the main . More explanations are given in the
gene help file
