Summary
[Wormbase] dpy-26 encodes a novel, acidic protein that is highly conserved in other Caenorhabditis species; during development, dpy-26 activity is required for both dosage compensation and meiotic chromosome segregation; DPY-26 localizes to all meiotic chromosomes in the germline and to the hermaphrodite X chromosomes in somatic cells; SDC-1, SDC-2, and SDC-3 proteins form a complex and these three proteins, in turn, colocalize with DPY-26, DPY-27, and MIX-1 proteins both on the X chromosome and on a transgenic her-1(+) array
.
Wormbase predicts one model.
AceView summary
According to AceView, this gene is
expressed at high level, 1.4 times the average gene in this release, at all stages of development [Kohara cDNAs]. The
sequence of this gene is defined by
19 cDNA clones. We annotate
structural defects or features in 2 cDNA clones.
The gene contains
9 distinct gt-ag introns. Transcription produces one mRNA. There are 3 validated
alternative polyadenylation sites (see the
diagram).
The spliced mRNA putatively encodes
a good protein, containing a vacuolar domain, a coiled coil stretch
[Psort2].
Function: There are
7 articles specifically referring to this gene in PubMed. In addition we point
below to 50 abstracts. This essential gene is associated to a
phenotype (DumPY : shorter than wild-type, increased meiotic non disjunction, maternal effect daughterless, X chromosome dosage compensation defect, embryonic and early larval arrest, shared oogenic and spermatogenic protein copurified with chromatin).
Please quote:
AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map: This essential gene dpy-26 maps on chomosome IV at position +6.68 (interpolated). In AceView, it covers
5.33 kb, from 12451266 to 12445935 (WS190), on the reverse strand.
Links to: WormBase,
NextDB,
RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 4N212, in Wormbase by its cosmid.number name C25G4.5, in NextDB, the Nematode expression pattern database, as CEYK136.
Legend
Introns are depicted by broken lines; the height of the top of each intron reflects the relative number of clones supporting this intron.
]^[ A pink broken line denotes an intron with standard boundaries (gt-ag or gc-ag) that is exactly supported (i.e. a cDNA sequence exactly matches the genome over 16 bp, 8 on both sides of the intron).
] ^ ] A blue broken line denotes non-standard introns, exactly supported, but with non-standard at-ac or any other boundaries.
]-[ Pink and
] - ] blue straight lines represent 'fuzzy' introns of the standard and non-standard types respectively, those introns do not follow the 16 bp rule. Black straight lines ]-[denote gaps in the alignments.
Exons: Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). Flags identify validated endings: cap site on the 5' side, polyadenylation site on the 3' side. Filled flags correspond to frequent events while empty flags have lesser supporting cDNAs (yet all are validated); at the 3' side, black flags are associated to the main AATAAA signal,
blue flags to any single letter variant of the main . More explanations are given in the
gene help file
