Caenorhabditis elegans gene dom-6, encoding cyclin-dependent kinase regulatory subunit, downstream Of Mes-6, in same operon.
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SUMMARY back to top
Summary
[Wormbase] A homolog of Cks/Suc1, a highly conserved member of the eukaryotic cell cycle machinery that affects both meiosis and mitosis and has a role in the inactivation of the M-phase promoting factor (MPF) during early embryogenesis.
Wormbase predicts one model
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AceView summary
According to AceView, this gene is well expressed, 0.5 times the average gene in this release. The sequence of this gene is defined by 7 cDNA clones.
The gene contains 1 gt-ag intron. Transcription produces one mRNA.
The spliced mRNA putatively encodes a good protein, containing Cyclin-dependent kinase, regulatory subunit domain [Pfam].
Function: There are 2 articles specifically referring to this gene in PubMed. In addition we point below to 4 abstracts. Functionally, the gene has been proposed to participate in a process (cell cycle).

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_IV, links to other databases and other names back to top ?
Map: This gene dom-6 maps on chomosome IV at position +4.46 (interpolated). In AceView, it covers 0.81 kb, from 8513903 to 8514712 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
as Other names: The gene is also known cks-1, in Wormgenes/AceView by its positional name 4J279, in Wormbase by its cosmid.number name C09G4.3, in NextDB, the Nematode expression pattern database, as CEYK6245.
Closest AceView homologs in other species back to top ?
The closest human genes, according to BlastP, are the AceView genes CKS1BP3 (e=2 10^-25), CKS1B (e=2 10^-25), LOC652904 (e=3 10^-25), CKS1BP2 (e=3 10^-25), CKS1A (e=2 10^-22), CKS2 (e=2 10^-23).
The closest mouse genes, according to BlastP, are the AceView genes EG624855 (e=2 10^-24), Cks1b (e=5 10^-23), Cks2 (e=8 10^-23), EG622657 (e=2 10^-20).
The closest A.thaliana genes, according to BlastP, are the AceView genes CKS2 (e=2 10^-23), CKS1\/CKS1AT (e=2 10^-22)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_IV back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes CI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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