Caenorhabditis elegans gene dhs-22, encoding DeHydrogenase, Short chain.
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SUMMARY back to top
Summary
[Wormbase] dhs-22 encodes a short-chain dehydrogenase predicted to be mitochondrial.
Wormbase predicts one model
.

AceView summary
According to AceView, this gene is well expressed, 1.1 times the average gene in this release, at all stages of development [Kohara cDNAs]. The sequence of this gene is defined by 15 cDNA clones, some from whole animal (seen once). We annotate structural defects or features in one cDNA clone.
The gene contains 3 distinct gt-ag introns. Transcription produces one mRNA. 83 bp of this gene are antisense to spliced gene set-31, raising the possibility of regulated alternate expression.
The spliced mRNA putatively encodes a good protein, containing Short-chain dehydrogenase/reductase SDR domain [Pfam].
Function: There is one article specifically referring to this gene in PubMed. Functionally, the gene has been proposed to participate in a process (metabolism). Proteins are expected to have molecular function (oxidoreductase activity).

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_V, links to other databases and other names back to top ?
Map: This gene dhs-22 maps on chomosome V at position +6.23 (interpolated). In AceView, it covers 1.38 kb, from 14421418 to 14420040 (WS190), on the reverse strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 5O900, in Wormbase by its cosmid.number name C15H11.4, in NextDB, the Nematode expression pattern database, as CEYK3514.
Closest AceView homologs in other species back to top ?
The closest human genes, according to BlastP, are the AceView genes RDH12 (e=5 10^-43), NT5C1BandRDH14 (e=9 10^-41), RDH13 (e=10^-38), DHRS13 (e=3 10^-37).
The closest mouse genes, according to BlastP, are the AceView genes Rdh12 (e=4 10^-41), Rdh14 (e=5 10^-41), Rdh13 (e=9 10^-38), Dhrs13andFlot2 (e=6 10^-37), Rdh11 (e=3 10^-36).
The closest A.thaliana genes, according to BlastP, are the AceView genes AT4G23430 (e=6 10^-48), AT2G37540 (e=6 10^-45), AT4G23420 (e=10^-43)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_V back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes C

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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