Summary
[Wormbase] deg-1 encodes a putative ion channel for which altered function induces necrotic cell death of neurons required for mechanosensory behavior; expressed in the ASH, IL1, AVD, AVG, and PVC neurons in addition to some muscle cells
.
Wormbase predicts one model.
AceView summary
According to AceView, this gene is
moderately expressed, only 30.4% of the average gene in this release, in L3, L4 larvae and in adult [Kohara and Riddle cDNAs]. The
sequence of this gene is defined by
4 cDNA clones. We annotate
structural defects or features in 2 cDNA clones.
The gene contains
15 distinct gt-ag introns. Transcription produces one mRNA. 54 bp of this gene
are antisense to spliced gene mec-7, raising the possibility of regulated alternate expression.
The spliced mRNA putatively encodes
a good protein, containing Na+ channel, amiloride-sensitive
domain [Pfam], some transmembrane domains, a coiled coil stretch
[Psort2].
Function: There are
14 articles specifically referring to this gene in PubMed. In addition we point
below to 47 abstracts. This gene is associated to a
phenotype (gain of function leads to DEGeneration of certain neurons). Functionally, the gene has been proposed to participate in a
process (sodium ion transport). Proteins are expected to have molecular
function (sodium channel activity) and to
localize in membrane.
Please quote:
AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map: This gene deg-1 maps on chomosome X at position -1.29 (measured by recombination), -0.98 (interpolated). In AceView, it covers
11.70 kb, from 7763151 to 7774852 (WS190), on the direct strand.
Links to: WormBase,
RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name XI393, in Wormbase by its cosmid.number name C47C12.6.
The closest human genes, according to BlastP, are the AceView genes
SCNN1B (e=8 10^-35),
SCNN1G (e=9 10^-34).
The closest mouse gene, according to BlastP, is the AceView gene
Scnn1g (e=9 10^-37)
Legend
Introns are depicted by broken lines; the height of the top of each intron reflects the relative number of clones supporting this intron.
]^[ A pink broken line denotes an intron with standard boundaries (gt-ag or gc-ag) that is exactly supported (i.e. a cDNA sequence exactly matches the genome over 16 bp, 8 on both sides of the intron).
] ^ ] A blue broken line denotes non-standard introns, exactly supported, but with non-standard at-ac or any other boundaries.
]-[ Pink and
] - ] blue straight lines represent 'fuzzy' introns of the standard and non-standard types respectively, those introns do not follow the 16 bp rule. Black straight lines ]-[denote gaps in the alignments.
Exons: Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). Flags identify validated endings: cap site on the 5' side, polyadenylation site on the 3' side. Filled flags correspond to frequent events while empty flags have lesser supporting cDNAs (yet all are validated); at the 3' side, black flags are associated to the main AATAAA signal,
blue flags to any single letter variant of the main . More explanations are given in the
gene help file
