Caenorhabditis elegans gene cyn-9, encoding CYclophiliN, peptidyl-prolyl cis-trans isomerase.
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SUMMARY back to top
Summary
[Wormbase] cyn-9 encodes a peptidyl prolyl cis-trans isomerase most similar to human cyclophilin G (OMIM:606093); CYN-9 likely functions as a catalyst in the folding and modification of cuticle collagens; a cyn-9::lacZ reporter is expressed in the syncytial hypodermis from early larval through adult stages; cyn-9 mRNA is expressed most strongly at the mid-L3 and mid-L4 larval stages, the intermoult period when collagens are synthesized.
Wormbase predicts one model
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AceView summary
According to AceView, this gene is well expressed, 0.5 times the average gene in this release, in embryos, L3 and L4 larvae, and adult [Kohara cDNAs]. The sequence of this gene is defined by 6 cDNA clones.
The gene contains 5 distinct gt-ag introns. Transcription produces one mRNA.
The spliced mRNA putatively encodes a good protein, containing Peptidyl-prolyl cis-trans isomerase, cyclophilin-type domain [Pfam].
Function: There are 3 articles specifically referring to this gene in PubMed. In addition we point below to 2 abstracts. No phenotype has yet been reported to our knowledge: this gene's in vivo function is yet unknown.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_III, links to other databases and other names back to top ?
Map: This gene cyn-9 maps on chomosome III at position -5.67 (interpolated). In AceView, it covers 1.81 kb, from 3699612 to 3697799 (WS190), on the reverse strand.
Links to: WormBase, NextDB, RNAiDB.
as Other names: The gene is also known cyp-9, in Wormgenes/AceView by its positional name 3E788, in Wormbase by its cosmid.number name T27D1.1, in NextDB, the Nematode expression pattern database, as CEYK6623.
EC number: This gene encodes protein number: EC 5.2.1.8.
Closest AceView homologs in other species back to top ?
The closest human genes, according to BlastP, are the AceView genes PPIG (e=10^-45), NKTR (e=9 10^-42), PPID (e=3 10^-41).
The closest mouse genes, according to BlastP, are the AceView genes Ppig (e=8 10^-46), Ppid (e=4 10^-43), Nktr (e=2 10^-42).
The closest A.thaliana gene, according to BlastP, is the AceView gene SQN (e=10^-46)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_III back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes C

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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