Caenorhabditis elegans gene cyn-12, encoding CYclophiliN, peptidyl-prolyl cis-trans isomerase.
TABLE OF CONTENTS / OPEN CLOSE ALL PARAGRAPHS
SUMMARY back to top
Summary
[Wormbase] cyn-12 encodes a member of the cyclophilin family that is related to human PPIL1 (CGI-124); based upon its sequence similarity, CYN-12 is predicted to be a cytoplasmic protein potentially involved in a wide range of signal transduction pathways.
Wormbase predicts one model
.

AceView summary
According to AceView, this gene is moderately expressed, only 30.4% of the average gene in this release. The sequence of this gene is defined by 4 cDNA clones, some from whole animal (seen once).
The gene contains 2 distinct gt-ag introns. Transcription produces one mRNA.
The spliced mRNA putatively encodes a good protein, containing Peptidyl-prolyl cis-trans isomerase, cyclophilin-type domain [Pfam]. No phenotype has yet been reported to our knowledge: this gene's in vivo function is yet unknown.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_IV, links to other databases and other names back to top ?
Map: This gene cyn-12 maps on chomosome IV at position +3.71 (interpolated). In AceView, it covers 1.09 kb, from 7133196 to 7132111 (WS190), on the reverse strand.
Links to: WormBase, RNAiDB.
as Other names: The gene is also known cyp-12, in Wormgenes/AceView by its positional name 4H894, in Wormbase by its cosmid.number name C34D4.12.
EC number: This gene encodes protein number: EC 5.2.1.8.
Closest AceView homologs in other species back to top ?
The closest human gene, according to BlastP, is the AceView gene PPIL1 (e=4 10^-54).
The closest mouse gene, according to BlastP, is the AceView gene Ppil1 (e=10^-54).
The closest A.thaliana gene, according to BlastP, is the AceView gene AT2G36130 (e=10^-51)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_IV back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes CI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Merci !