Summary
[Wormbase] cps-6 encodes an ortholog of human mitochondrial endonuclease G (EndoG) that promotes apoptosis, and is required to degrade nicked (TUNEL-positive) DNA in apoptotic cells; transgenic CPS-6 is localized to mitochondria, but transgenic CPS-6 lacking a mitochondrial localization sequence is found in nuclei, and nuclei may be the in vivo target of CPS-6 after its activation by CED-3; CPS-6 has magnesium-dependent nuclease activity in vitro; cps-6(sm116) and cps-6(RNAi) animals have delayed CED-3-induced apoptosis, and cps-6(sm116) suppresses a constitutively active ced-3 transgene; cps-6(sm116) can be transgenically rescued by mouse EndoG; CPS-6 binds WAH-1 (an apoptosis-inducing factor ortholog) in vitro, WAH-1 binding enhances CPS-6's endonuclease activity, and constitutive transgenic coexpression of cps-6 with wah-1 induces cell death not seen with constitutive expression of either cps-6 or wah-1 alone; CPS-6 binds CRN-1 (a flap endonuclease ortholog) in vitro, and may form a large complex in vivo with CRN-1, CRN-4, CRN-5, CYP-13, and WAH-1; CRN-1 enhances CPS-6's endonuclease activity in vitro, CPS-6 enhances CRN-1's gap-dependent endonuclease and 5'-3' exonuclease activities, and cps-6 is required for excess cell deaths induced by a crn-1 transgene.
Wormbase predicts one model.

AceView summary
According to AceView, this gene is well expressed, 0.5 times the average gene in this release, from L1 larvae to adult [Kohara cDNAs]. The sequence of this gene is defined by 7 cDNA clones, some from whole animal (seen once).
The gene contains 4 distinct gt-ag introns. Transcription produces one mRNA.
The spliced mRNA putatively encodes a good protein, containing DNA/RNA non-specific endonuclease domain [Pfam], a vacuolar domain [Psort2].
Function: There are 5 articles specifically referring to this gene in PubMed. In addition we point below to 3 abstracts. This gene is associated to a phenotype (CED-3 Protease Suppressor). Functionally, the gene has been proposed to participate in a process (DNA degradation in apoptosis). Proteins are expected to have molecular functions (endonuclease activity, nucleic acid binding activity) and to localize in cytoplasm.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Map: This gene cps-6 maps on chomosome I at position -1.30 (interpolated). In AceView, it covers 1.88 kb, from 4448462 to 4446586 (WS190), on the reverse strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 1F14, in Wormbase by its cosmid.number name C41D11.8, in NextDB, the Nematode expression pattern database, as CEYK9485.

The closest human gene, according to BlastP, is the AceView gene ENDOG (e=8 10^-62).
The closest mouse gene, according to BlastP, is the AceView gene Endog (e=9 10^-64).
The closest A.thaliana genes, according to BlastP, are the AceView genes AT3G51990 (e=0.35), AT3G47840 (e=0.68)

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