Caenorhabditis elegans gene cpr-5, encoding cysteine PRotease cathepsin B-like.
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SUMMARY back to top
Summary
[Wormbase] cpr-5 encodes a cysteine protease.
Wormbase predicts one model, but Caenorhabditis elegans cDNA sequences in GenBank, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 2 spliced variants.

AceView summary
Expression: According to AceView, this gene is expressed at very high level, 13.9 times the average gene in this release, mostly from L1 larvae to adult [Kohara cDNAs]. The sequence of this gene is defined by 183 cDNA clones, some from whole animal (seen once). We annotate structural defects or features in 6 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 2 distinct gt-ag introns. Transcription produces 2 alternatively spliced mRNAs. The mRNAs appear to differ by by overlapping exons with different boundaries.
Protein coding potential: The 2 spliced mRNAs putatively encode good proteins, altogether 2 different isoforms (1 complete, 1 COOH complete, 1 partial), some containing peptidase C1A, papain C-terminal domain [Pfam]; the complete protein appears to be secreted.
Function: There are 3 articles specifically referring to this gene in PubMed. In addition we point below to 3 abstracts. Functionally, the gene has been proposed to participate in a process (proteolysis and peptidolysis). Proteins are expected to have molecular function (cysteine-type peptidase activity) and to localize in extracellular space.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_V, links to other databases and other names back to top ?
Map: This gene cpr-5 maps on chomosome V at position -20.18 (interpolated). In AceView, it covers 1.38 kb, from 1133974 to 1132592 (WS190), on the reverse strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 5B612, in Wormbase by its cosmid.number name W07B8.5, in NextDB, the Nematode expression pattern database, as CEYK1544.
Closest AceView homologs in other species back to top ?
The closest human gene, according to BlastP, is the AceView gene CTSB (e=6 10^-46).
The closest mouse gene, according to BlastP, is the AceView gene Ctsb (e=9 10^-45).
The closest A.thaliana genes, according to BlastP, are the AceView genes AT4G01610 (e=2 10^-25), AT1G02300 (e=2 10^-21)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNA clones supporting each intron. Superimposed introns of the same color are identical, of different colors are different.
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. Details on tissue of origin for each intron and exon is available from the intron and exons table. Good predicted proteins are in pink, yellow proteins may be partial or unconvincing, green are uORFs. Proteins supported by a single continuous GenBank accession lead to underlining the name/ending of the variant. Names not underlined result from cDNA concatenation in the coding region and should be experimentally checked.
More legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_V back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA:.a, .b Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function and related genes CI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare all variants, their summarized annotations, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Merci !