Caenorhabditis elegans gene cpr-4, encoding cysteine PRotease related.
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SUMMARY back to top
Summary
[Wormbase] cpr-4 encodes a cathepsin B-like cysteine protease expressed at all life stages.
Wormbase predicts one model
.

AceView summary
According to AceView, this gene is expressed at high level, 3.8 times the average gene in this release, mostly from L1 larvae to adult [Kohara cDNAs]. The sequence of this gene is defined by 50 cDNA clones, some from whole animal (seen 2 times). We annotate structural defects or features in 7 cDNA clones.
The gene contains 1 gt-ag intron. Transcription produces one mRNA. There are 2 validated alternative polyadenylation sites (see the diagram).
The spliced mRNA putatively encodes a good protein, containing peptidase C1A, papain C-terminal domain [Pfam]; the complete protein appears to be secreted.
Function: There are 2 articles specifically referring to this gene in PubMed. In addition we point below to 2 abstracts. Functionally, the gene has been proposed to participate in a process (proteolysis and peptidolysis). Proteins are expected to have molecular function (cysteine-type peptidase activity) and to localize in extracellular space.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_V, links to other databases and other names back to top ?
Map: This gene cpr-4 maps on chomosome V at position +0.13 (interpolated). In AceView, it covers 1.18 kb, from 6614658 to 6615836 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 5H95, in Wormbase by its cosmid.number name F44C4.3, in NextDB, the Nematode expression pattern database, as CEYK2094.
Closest AceView homologs in other species back to top ?
The closest human gene, according to BlastP, is the AceView gene CTSB (e=6 10^-81).
The closest mouse gene, according to BlastP, is the AceView gene Ctsb (e=10^-80).
The closest A.thaliana genes, according to BlastP, are the AceView genes AT4G01610 (e=7 10^-61), AT1G02300 (e=10^-57), AT1G02305 (e=2 10^-57)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_V back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes C

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Merci !