Summary
[Wormbase] coq-2 encodes a putative para-hydroxybenzoate-polyprenyl transferase (UbiA prenyltransferase), orthologous to S. cerevisiae COQ2; COQ-2 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; coq-2 mutants have slowed pharyngeal pumping, and eventually arrest as paralysed larvae before dying; coq-2(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans; coq-2 mutants are not rescued by dietary coenzyme Q.
Wormbase predicts 5 models.

AceView summary
Expression: According to AceView, this gene is well expressed, 0.8 times the average gene in this release, at all stages of development [Kohara cDNAs]. The sequence of this gene is defined by 11 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 11 distinct gt-ag introns. Transcription produces 4 alternatively spliced mRNAs. There are 2 probable alternative promotors and 3 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by by truncation of the 5' end, presence or absence of 3 cassette exons, overlapping exons with different boundaries, splicing versus retention of one intron. 180 bp of this gene are antisense to spliced gene 3I26, raising the possibility of regulated alternate expression.
2 variants were isolated in vivo, despite the fact that they are predicted targets of nonsense mediated mRNA decay (NMD).
Protein coding potential: The 4 spliced mRNAs putatively encode good proteins, altogether 8 different isoforms (3 complete, 6 COOH complete), some containing UbiA prenyltransferase domain [Pfam], some transmembrane domains [Psort2].
Function: There is one article specifically referring to this gene in PubMed. Proteins are expected to have molecular function (prenyltransferase activity) and to localize in various compartments (endoplasmic reticulum membrane, integral to membrane). No phenotype has yet been reported to our knowledge: this gene's in vivo function is yet unknown.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Map: This gene coq-2 maps on chomosome III at position -0.92 (interpolated). In AceView, it covers 4.18 kb, from 6935903 to 6940081 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 3I27, in Wormbase by its cosmid.number name F57B9.4, in NextDB, the Nematode expression pattern database, as CEYK6809.

The closest human gene, according to BlastP, is the AceView gene COQ2 (e=7 10^-54).
The closest mouse gene, according to BlastP, is the AceView gene Coq2 (e=10^-55).
The closest A.thaliana gene, according to BlastP, is the AceView gene ATPPT1 (e=2 10^-47)

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNA clones supporting each intron. Superimposed introns of the same color are identical, of different colors are different.
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. Details on tissue of origin for each intron and exon is available from the intron and exons table. Good predicted proteins are in pink, yellow proteins may be partial or unconvincing, green are uORFs. Proteins supported by a single continuous GenBank accession lead to underlining the name/ending of the variant. Names not underlined result from cDNA concatenation in the coding region and should be experimentally checked.
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