Summary
[Wormbase] ceh-21 encodes a a ONECUT class CUT homeobox protein with a single N-terminal cut domain and an OCAM domain; the cut domain may be a compact DNA-binding domain composed of alpha helices; the OCAM domain is a nematode-specific motif conserved between CEH-21, CEH-41, and T02B5.2; ceh-21 is one of three nematode-specific ONECUT genes in a cluster with ceh-39 and ceh-41; CEH-21 may be required for muscle formation and differentiation, and is expressed in muscle precursor cells and differentiated gut cells; ceh-21 has no obvious function in mass RNAi assays.
Wormbase predicts one model, but Caenorhabditis elegans cDNA sequences in GenBank, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 2 spliced variants.

AceView summary
Expression: According to AceView, this gene is well expressed, 1.4 times the average gene in this release, mostly in embryos, and some at all stages of development [Kohara cDNAs]. The sequence of this gene is defined by 18 cDNA clones, some from whole animal (seen once).
Alternative mRNA variants and regulation: The gene contains 6 distinct gt-ag introns. Transcription produces 2 alternatively spliced mRNAs. There are 2 non overlapping alternative last exons and 3 validated alternative polyadenylation sites (see the diagram).
Protein coding potential: The 2 spliced mRNAs putatively encode the same good protein, some containing domains Homeodomain protein CUT, homeobox [Pfam], a second peroximal domain [Psort2].
Function: There are 3 articles specifically referring to this gene in PubMed. In addition we point below to 8 abstracts. Functionally, the gene has been proposed to participate in a process (regulation of transcription, DNA-dependent). Proteins are expected to have molecular functions (DNA binding activity, transcription factor activity) and to localize in nucleus.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Map: This gene ceh-21 maps on chomosome X at position -16.65 (interpolated). In AceView, it covers 3.97 kb, from 1852738 to 1848772 (WS190), on the reverse strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name XC468, in Wormbase by its cosmid.number name T26C11.6, in NextDB, the Nematode expression pattern database, as CEYK4791.

The closest human genes, according to BlastP, are the AceView genes ONECUT1 (e=10^-28), ONECUT2 (e=6 10^-28), ONECUT3 (e=6 10^-27).
The closest mouse genes, according to BlastP, are the AceView genes Onecut1 (e=6 10^-29), Onecut2 (e=3 10^-28), Onecut3 (e=2 10^-27)

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNA clones supporting each intron. Superimposed introns of the same color are identical, of different colors are different.
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. Details on tissue of origin for each intron and exon is available from the intron and exons table. Good predicted proteins are in pink, yellow proteins may be partial or unconvincing, green are uORFs. Proteins supported by a single continuous GenBank accession lead to underlining the name/ending of the variant. Names not underlined result from cDNA concatenation in the coding region and should be experimentally checked.
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