Caenorhabditis elegans essential gene ced-3, encoding cell death protein, Caspase, ICE-like apoptotic protease, CEll Death abnormality.
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SUMMARY back to top
Summary
[Wormbase] The ced-3 gene encodes a protease required for apoptosis.
Wormbase predicts one model.

AceView summary
According to AceView, this gene is well expressed, 0.6 times the average gene in this release, in embryos [Kohara cDNAs]. The sequence of this gene is defined by 8 cDNA clones.
The gene contains 7 distinct gt-ag introns. Transcription produces one mRNA. There are 4 validated alternative polyadenylation sites (see the diagram).
The spliced mRNA putatively encodes a good protein, containing domains Caspase Recruitment, Peptidase C14, caspase catalytic [Pfam].
Function: There are 179 articles specifically referring to this gene in PubMed. In addition we point below to 166 abstracts. This essential gene is associated to a phenotype (CEll Death abnormality, Sterile adult). Functionally, the gene has been proposed to participate in processes (proteolysis and peptidolysis, regulation of apoptosis). Proteins are expected to have molecular functions (cysteine-type endopeptidase activity, protein binding activity) and to localize in intracellular.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_IV, links to other databases and other names back to top ?
Map: This essential gene ced-3 maps on chomosome IV at position +8.46 (interpolated). In AceView, it covers 5.85 kb, from 13204098 to 13198245 (WS190), on the reverse strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 4N964, in Wormbase by its cosmid.number name C48D1.2, in NextDB, the Nematode expression pattern database, as CEYK4316.
Closest AceView homologs in other species back to top ?
The closest human genes, according to BlastP, are the AceView genes CASP3 (e=6 10^-33), CASP7 (e=6 10^-33), TMEM139andCASP2 (e=10^-30), PLA2G12AandCASP6 (e=3 10^-30).
The closest mouse genes, according to BlastP, are the AceView genes Casp7 (e=7 10^-34), Casp2 (e=10^-30), Casp3 (e=10^-30), Casp6 (e=2 10^-28)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_IV back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes DCI

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Merci !