Summary
[Wormbase] cdk-1 encodes a cyclin-dependent kinase, orthologous to and functionally interchangeable with CDC28 from S. cerevisiae; CDK-1 is required for cell-cycle progression through M phase in both meiosis and mitosis.
Wormbase predicts one model, but Caenorhabditis elegans cDNA sequences in GenBank, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 2 spliced variants.

AceView summary
Expression: According to AceView, this gene is expressed at high level, 2.0 times the average gene in this release, at all stages of development [Kohara cDNAs]. The sequence of this gene is defined by 26 cDNA clones. We annotate structural defects or features in one cDNA clone.
Alternative mRNA variants and regulation: The gene contains 4 distinct gt-ag introns. Transcription produces 2 alternatively spliced mRNAs. There are 3 validated alternative polyadenylation sites (see the diagram).
Protein coding potential: The 2 spliced mRNAs putatively encode the same good protein, some containing domains Serine/threonine protein kinase-related, tyrosine protein kinase [Pfam].
Function: There are 8 articles specifically referring to this gene in PubMed. In addition we point below to 18 abstracts. This essential gene is associated to a phenotype (abnormal pseudocleavage, catastrophic one cell arrest, Embryonic Lethal, Nematode Cell Cycle associated, osmotic or pressure sensitive, Progress through meiotic divisions, required for M phase in meiotic and mitotic cell divisions, shape of one cell embryos abnormal, Sterile adult, STerile and Uncoordinated, STerile Progeny, UNCoordinated locomotion, oogenic protein copurified with chromatin, polar bodies (female meiosis products) abnormal, slow cell cycle). Functionally, the gene has been proposed to participate in processes (osmoregulation, pseudocleavage (sensu Nematoda), protein amino acid phosphorylation). Proteins are expected to have molecular functions (ATP binding activity, protein kinase activity, protein tyrosine kinase activity) and to localize in cytoplasm.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Map: This essential gene cdk-1 maps on chomosome III at position +0.79 (interpolated). In AceView, it covers 1.43 kb, from 9747332 to 9748756 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
as Other names: The gene is also known ncc-1, in Wormgenes/AceView by its positional name 3K837, in Wormbase by its cosmid.number name T05G5.3, in NextDB, the Nematode expression pattern database, as CEYK2952.

The closest human genes, according to BlastP, are the AceView genes CDC2 (e= 10^-115), CDK3 (e= 10^-106), CDK2 (e= 10^-104).
The closest mouse genes, according to BlastP, are the AceView genes Cdc2a (e= 10^-114), Cdk2 (e= 10^-105)

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNA clones supporting each intron. Superimposed introns of the same color are identical, of different colors are different.
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. Details on tissue of origin for each intron and exon is available from the intron and exons table. Good predicted proteins are in pink, yellow proteins may be partial or unconvincing, green are uORFs. Proteins supported by a single continuous GenBank accession lead to underlining the name/ending of the variant. Names not underlined result from cDNA concatenation in the coding region and should be experimentally checked.
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