Summary
[Wormbase] cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates.
Wormbase predicts 3 models.

AceView summary
Expression: According to AceView, this gene is expressed at high level, 2.1 times the average gene in this release, at all stages of development [Kohara cDNAs]. The sequence of this gene is defined by 27 cDNA clones, some from whole animal (seen once). We annotate structural defects or features in 7 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 13 distinct gt-ag introns. Transcription produces 3 different mRNAs, 2 alternatively spliced variants and 1 unspliced form. There are 2 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by by overlapping exons with different boundaries.
Protein coding potential: The 2 spliced and the unspliced mRNAs putatively encode good proteins, altogether 6 different isoforms (1 complete, 4 COOH complete, 1 partial), some containing domains Bromodomain, Protein of unknown function DUF902, CREBbp, Transcriptional coactivation, Coactivator CBP, KIX, Zinc finger, TAZ-type, Zinc finger, ZZ-type [Pfam], a coiled coil stretch [Psort2].
Function: There are 9 articles specifically referring to this gene in PubMed. In addition we point below to 15 abstracts. This essential gene is associated to a phenotype (cell determination and differentiation, Defect in cell division, Embryonic Lethal (zygotic), Sterile adult, unhealthy). Functionally, the gene has been proposed to participate in processes (regulation of transcription, regulation of transcription, DNA-dependent). Proteins are expected to have molecular functions (histone acetyltransferase activity, protein binding activity, transcription co-activator activity, transcription cofactor activity, zinc ion binding activity) and to localize in nucleus.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Map: This essential gene cbp-1 maps on chomosome III at position +0.83 (interpolated). In AceView, it covers 8.31 kb, from 9766415 to 9774724 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 3K863, in Wormbase by its cosmid.number name R10E11.1, in NextDB, the Nematode expression pattern database, as CEYK1421.

The closest human genes, according to BlastP, are the AceView genes EP300 (e=0.0), CREBBP (e=0.0).
The closest mouse genes, according to BlastP, are the AceView genes Ep300 (e=0.0), Crebbp (e=0.0).
The closest A.thaliana genes, according to BlastP, are the AceView genes HAC1 (e=4 10^-63), ATHPCAT4\/HAC5 (e=2 10^-62), HAC12 (e=2 10^-62)

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNA clones supporting each intron. Superimposed introns of the same color are identical, of different colors are different.
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. Details on tissue of origin for each intron and exon is available from the intron and exons table. Good predicted proteins are in pink, yellow proteins may be partial or unconvincing, green are uORFs. Proteins supported by a single continuous GenBank accession lead to underlining the name/ending of the variant. Names not underlined result from cDNA concatenation in the coding region and should be experimentally checked.
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