Summary
[Wormbase] ard-1 encodes a homolog of mammalian 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD) that is predicted to be mitochondrial
.
Wormbase predicts one model.
AceView summary
According to AceView, this gene is
expressed at high level, 2.1 times the average gene in this release, mostly in embryos, and some at all stages of development [Kohara cDNAs]. The
sequence of this gene is defined by
27 cDNA clones, some from whole animal (seen once). We annotate
structural defects or features in 2 cDNA clones.
The gene contains
5 distinct gt-ag introns. Transcription produces one mRNA.
The spliced mRNA putatively encodes
a good protein, containing
domains Short-chain dehydrogenase/reductase SDR, NAD-dependent epimerase/dehydratase, Polyketide synthase, KR [Pfam].
Function: There is
one article specifically referring to this gene in PubMed. This gene is associated to a
phenotype (shared oogenic and spermatogenic protein copurified with chromatin). Functionally, the gene has been proposed to participate in a
process (metabolism). Proteins are expected to have molecular
functions (coenzyme binding, enzyme activity, oxidoreductase activity) and to
localize in cytoplasm.
Please quote:
AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map: This gene ard-1 maps on chomosome IV at position +5.08 (interpolated). In AceView, it covers
2.52 kb, from 11131251 to 11133767 (WS190), on the direct strand.
Links to: WormBase,
NextDB,
RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 4L897, in Wormbase by its cosmid.number name F01G4.2, in NextDB, the Nematode expression pattern database, as CEYK5057.
The closest human gene, according to BlastP, is the AceView gene
HSD17B10 (e=6 10^-81).
The closest mouse gene, according to BlastP, is the AceView gene
Hsd17b10 (e=2 10^-81).
The closest A.thaliana genes, according to BlastP, are the AceView genes
AT3G26770 (e=3 10^-23),
AT3G26760 (e=9 10^-22),
AT2G47120 (e=2 10^-20),
AT3G51680 (e=3 10^-20),
AT3G29250 (e=4 10^-20),
AT2G47130 (e=6 10^-20),
AT1G54870 (e=2 10^-19)
Legend
Introns are depicted by broken lines; the height of the top of each intron reflects the relative number of clones supporting this intron.
]^[ A pink broken line denotes an intron with standard boundaries (gt-ag or gc-ag) that is exactly supported (i.e. a cDNA sequence exactly matches the genome over 16 bp, 8 on both sides of the intron).
] ^ ] A blue broken line denotes non-standard introns, exactly supported, but with non-standard at-ac or any other boundaries.
]-[ Pink and
] - ] blue straight lines represent 'fuzzy' introns of the standard and non-standard types respectively, those introns do not follow the 16 bp rule. Black straight lines ]-[denote gaps in the alignments.
Exons: Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). Flags identify validated endings: cap site on the 5' side, polyadenylation site on the 3' side. Filled flags correspond to frequent events while empty flags have lesser supporting cDNAs (yet all are validated); at the 3' side, black flags are associated to the main AATAAA signal,
blue flags to any single letter variant of the main . More explanations are given in the
gene help file
