Caenorhabditis elegans essential gene apn-1, encoding endonuclease IV, has intrinsic apurinic/apyrimidinic endonuclease and 3'-diesterase activities; affects base excision repair.
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SUMMARY back to top
Summary
[Wormbase] apn-1 encodes a member of the AP (apurinic or apyrimidinic) endonuclease family.
Wormbase predicts one model
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AceView summary
According to AceView, this gene is well expressed, 0.6 times the average gene in this release, from L1 larvae to adult [Kohara cDNAs]. The sequence of this gene is defined by 8 cDNA clones. We annotate structural defects or features in one cDNA clone.
The gene contains 2 distinct gt-ag introns. Transcription produces one mRNA. There are 2 validated alternative polyadenylation sites (see the diagram). 90 bp of this gene are antisense to spliced gene 2I340, raising the possibility of regulated alternate expression.
The spliced mRNA putatively encodes a good protein, containing Xylose isomerase-type TIM barrel domain [Pfam].
Function: There are 3 articles specifically referring to this gene in PubMed. In addition we point below to one abstract. This essential gene is associated to a phenotype (affects base excision repair, embryonic lethal, partial).

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_II, links to other databases and other names back to top ?
Map: This essential gene apn-1 maps on chomosome II at position +0.57 (interpolated). In AceView, it covers 1.54 kb, from 8047494 to 8049035 (WS190), on the direct strand.
Links to: WormBase, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 2I339, in Wormbase by its cosmid.number name T05H10.2.
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_II back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes DC

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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