Caenorhabditis elegans gene aex-5, aboc, EXpulsion defective, encoding kex-2 Proprotein Convertase.
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SUMMARY back to top
Summary
[Wormbase] an ortholog of calcium-dependent serine endoproteinases, the kex2/subtilisin-like proprotein convertase that affects defecation cycle and anterior body contractions; and is expressed in all muscle cells except pharyngeal muscles.
Wormbase predicts one model.

AceView summary
According to AceView, this gene is well expressed, 0.7 times the average gene in this release, mostly from L2 larvae to adult [Kohara cDNAs]. The sequence of this gene is defined by 9 cDNA clones. We annotate structural defects or features in 2 cDNA clones.
The gene contains 7 distinct gt-ag introns. Transcription produces one mRNA. 89 bp of this gene are antisense to spliced gene 1P441, raising the possibility of regulated alternate expression.
The spliced mRNA putatively encodes a good protein, containing domains Peptidase S8 and S53, subtilisin, kexin, sedolisin, Proprotein convertase, P [Pfam]; the complete protein appears to be secreted.
Function: There are 2 articles specifically referring to this gene in PubMed. In addition we point below to 6 abstracts. This gene is associated to a phenotype (Aboc, EXpulsion defective, Anterior contraction and EXpulsion defect during defecation). Functionally, the gene has been proposed to participate in a process (proteolysis and peptidolysis). Proteins are expected to have molecular function (serine-type endopeptidase activity) and to localize in extracellular space.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_I, links to other databases and other names back to top ?
Map: This gene aex-5 maps on chomosome I at position +27.27 (interpolated). In AceView, it covers 5.77 kb, from 14855816 to 14850043 (WS190), on the reverse strand.
Links to: WormBase, NextDB, RNAiDB.
as Other names: The gene is also known kpc-3, kpc-5, in Wormgenes/AceView by its positional name 1P448, in Wormbase by its cosmid.number name F32A7.6, in NextDB, the Nematode expression pattern database, as CEYK1810.
Closest AceView homologs in other species back to top ?
The closest human genes, according to BlastP, are the AceView genes PCSK1 (e=3 10^-66), PCSK5 (e=8 10^-66), PCSK4 (e=10^-65), PCSK6 (e=2 10^-65), FURIN (e=2 10^-63), PCSK2 (e=10^-61).
The closest mouse genes, according to BlastP, are the AceView genes Pcsk1 (e=4 10^-67), Pcsk6 (e=9 10^-67), Pcsk5 (e=2 10^-65), Furin (e=2 10^-64), Pcsk4 (e=9 10^-63), Pcsk2 (e=6 10^-61)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_I back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes DC

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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