Caenorhabditis elegans gene ace-4, abnormal ACEtylcholinesterase, encoding acetylcholinesterase class C, serine hydrolase.
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SUMMARY back to top
Summary
The gene ace-4 encodes a rare form of acetylcholinesterase class C, closer to ACE-3 (with which it forms a direct tandem repeat) than ACE-1 or ACE-2 by sequence [Grauso et al, 1998; Combes et al, 2000]. Its activity is not detected in vivo. The usual sequence FGESAG surrounding the active serine residue in cholinesterases is changed to FGQSAG. ace-4 is expressed at least in L2 larvae [Kohara cDNA][Wormbase] ace-4 encodes an divergent acetylcholinesterase homolog with biochemically undetectable activity.
Wormbase predicts one model
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AceView summary
According to AceView, this gene is moderately expressed, only 30.4% of the average gene in this release. The sequence of this gene is defined by 4 cDNA clones. We annotate structural defects or features in one cDNA clone.
The gene contains 16 distinct gt-ag introns. Transcription produces one mRNA.
The spliced mRNA putatively encodes a good protein, altogether 2 different isoforms (2 COOH complete), containing Carboxylesterase, type B domain [Pfam].
Function: There are 6 articles specifically referring to this gene in PubMed. In addition we point below to one abstract. This gene is associated to a phenotype (abnormal ACEtylcholinesterase).

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Map on chromosome CHROMOSOME_II, links to other databases and other names back to top ?
Map: This gene ace-4 maps on chomosome II at position +23.57 (interpolated). In AceView, it covers 7.41 kb, from 14197949 to 14205356 (WS190), on the direct strand.
Links to: WormBase, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 2O495, in Wormbase by its cosmid.number name Y48B6A.7.
Closest AceView homologs in other species back to top ?
The closest human genes, according to BlastP, are the AceView genes BCHE (e=10^-98), ACHE (e=6 10^-88).
The closest mouse genes, according to BlastP, are the AceView genes Bche (e=9 10^-98), Acheand2700038N03Rik (e=10^-88).
The closest A.thaliana genes, according to BlastP, are the AceView genes AT3G02410 (e=0.007), ATPCME (e=0.017), AT1G26120 (e=0.027)
Complete gene on genome diagram:               (in true scale, with colored introns) back to top
Compact gene diagram back to top
Legend
Sequences back to top
What is known about the gene and its neighbors on chromosome CHROMOSOME_II back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         (see the Legend)
Annotated mRNA diagrams back to top
Bibliography back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function and related genes DC

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function and related genes' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function and related genes' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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